Publications by authors named "James Stables"

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Synthesis and research of benzylamides of some isocyclic and heterocyclic acids as potential anticonvulsants.
Marzanna Strupińska, Grazyna Rostafińska-Suchar, Elzbieta Pirianowicz-Chaber, James P Stables, Jeff Jiang

Acta Pol Pharm· September 2013

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Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues.
Mohamed Jawed Ahsan, Habibullah Khalilullah, James P Stables, Jeyabalan Govindasamy

J Enzyme Inhib Med Chem· June 2013

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In silico validation and structure activity relationship study of a series of pyridine-3-carbohydrazide derivatives as potential anticonvulsants in generalized and partial seizures.
Reema Sinha, Udai Vir Singh Sara, Ratan Lal Khosa, James Stables, Jainendra Jain

Cent Nerv Syst Agents Med Chem· June 2013

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Psychomotor seizure test, neurotoxicity and in vitro neuroprotection assay of some semicarbazone analogues.
Mohamed Jawed Ahsan, James P Stables

Cent Nerv Syst Agents Med Chem· June 2013

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POMA analyses as new efficient bioinformatics' platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues.
Mohamed Jawed Ahsan, Jeyabalan Govindasamy, Habibullah Khalilullah, Govind Mohan, James P Stables

Bioorg Med Chem Lett· December 2012

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Search for anticonvulsant and analgesic active derivatives of dihydrofuran-2(3H)-one.
Krzysztof Więckowski, Kinga Sałat, Justyna Bytnar, Marek Bajda, Barbara Filipek, James P Stables

Bioorg Med Chem· November 2012

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Enaminones 12. An explanation of anticonvulsant activity and toxicity per Linus Pauling's clathrate hypothesis.
Patrice L Jackson, Clive D Hanson, Alanna K Farrell, Raymond J Butcher, James P Stables

Eur J Med Chem· May 2012

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Identification of new epilepsy treatments: issues in preclinical methodology.
Aristea S Galanopoulou, Paul S Buckmaster, Kevin J Staley, Solomon L Moshé, Emilio Perucca, James Stables

Epilepsia· March 2012

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Design, synthesis and anticonvulsant evaluation of novel N-(4-substituted phenyl)-2-[4-(substituted) benzylidene]-hydrazinecarbothio amides.
Laxmi Tripathi, Praveen Kumar, Ranjit Singh, James P Stables

Eur J Med Chem· January 2012

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A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
H Steve White, Anitha B Alex, Amanda Pollock, Naama Hen, Tawfeeq Shekh-Ahmad, James P Stables

Epilepsia· January 2012

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Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties.
Amber M King, Christophe Salomé, Elise Salomé-Grosjean, Marc De Ryck, Rafal Kaminski, James P Stables

J Med Chem· October 2011

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Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide.
Amber M King, Marc De Ryck, Rafal Kaminski, Anne Valade, James P Stables

J Med Chem· October 2011

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Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.
Nadeem Siddiqui, M Shamsher Alam, James P Stables

Eur J Med Chem· June 2011

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Design, synthesis and potential 6 Hz psychomotor seizure test activity of some novel 2-(substituted)-3-{[substituted]amino}quinazolin-4(3H)-one.
Praveen Kumar, Birendra Shrivastava, Surendra N Pandeya, James P Stables

Eur J Med Chem· April 2011

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Design & synthesis of N'-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents.
Laxmi Tripathi, Ranjit Singh, James P Stables

Eur J Med Chem· February 2011

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Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels.
Yuying Wang, Ki Duk Park, Christophe Salome, Sarah M Wilson, James P Stables

ACS Chem Neurosci· February 2011

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Menthone aryl acid hydrazones: a new class of anticonvulsants.
Jainendra Jain, Y Kumar, Reema Sinha, Rajeev Kumar, James Stables

Med Chem· January 2011

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Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties.
Nicole Pages, Pierre Maurois, Bernadette Delplanque, Pierre Bac, James P Stables

Neurosci Res· December 2010

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Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models.
Valentina Zuliani, Marco Fantini, Aradhya Nigam, James P Stables, Manoj K Patel

Bioorg Med Chem· November 2010

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1,3-diaryl-2-propenones and 2-benzylidene-1,3-indandiones: a quest for compounds displaying greater toxicity to neoplasms than normal cells.
Hari N Pati, Umashankar Das, Hiroshi Sakagami, Masame Kawase, Qing Chu, James P Stables

Arch Pharm (Weinheim)· September 2010

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The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.
Pierre Morieux, Christophe Salomé, Ki Duk Park, James P Stables, Harold Kohn

J Med Chem· August 2010

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1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action.
Joseph Vamecq, Pierre Maurois, Nicole Pages, Pierre Bac, James P Stables

Eur J Med Chem· July 2010

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Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group.
Ki Duk Park, James P Stables, Rihe Liu, Harold Kohn

Org Biomol Chem· June 2010

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Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
Christophe Salomé, Elise Salomé-Grosjean, James P Stables, Harold Kohn

J Med Chem· May 2010

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Menthone semicarbazides and thiosemicarbazides as anticonvulsant agents.
Jainendra Jain, Y Kumar, James Stables, Reema Sinha

Med Chem· January 2010

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