Publications by authors named "James Tobin"

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Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.
Jingsong Cao, Sylvie Perez, Bryan Goodwin, Qingcong Lin, Haibing Peng, James F Tobin

Am J Physiol Endocrinol Metab· May 2014

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Predictors of readmission to a psychiatry inpatient unit.
Jay Moss, Abby Li, James Tobin, Izak S Weinstein, Tetsuhiro Harimoto

Compr Psychiatry· April 2014

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Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.
Zhao-Kui Wan, Eva Chenail, Huan-Qiu Li, Manus Ipek, Jason Xiang, James F Tobin

ACS Med Chem Lett· January 2013

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Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.
Jingsong Cao, Yingjiang Zhou, Haibing Peng, Xinyi Huang, Shannon Stahler, James F Tobin

J Biol Chem· December 2011

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A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.
Lacramioara Ivanciu, Raffaella Toso, Paris Margaritis, Giulia Pavani, Haein Kim, James F Tobin

Nat Biotechnol· October 2011

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PPARdelta Agonism for the Treatment of Obesity and Associated Disorders: Challenges and Opportunities.
Mylène Perreault, David V Erbe, James F Tobin

PPAR Res· July 2011

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GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.
Dandan Shan, Jian-liang Li, Leeying Wu, Dongmei Li, Jonathan Hurov, James F Tobin

J Lipid Res· July 2010

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Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
Zhao-Kui Wan, Eva Chenail, Jason Xiang, Huan-Qiu Li, Manus Ipek, James F Tobin

J Med Chem· September 2009

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H6PDH interacts directly with 11beta-HSD1: implications for determining the directionality of glucocorticoid catalysis.
Yan-ling Zhang, Xiaotian Zhong, Zheni Gjoka, Yuanhong Li, Wayne Stochaj, James F Tobin

Arch Biochem Biophys· March 2009

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Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB.
Frédéric Tremblay, Tracy Revett, Christine Huard, Ying Zhang, James F Tobin

J Biol Chem· March 2009

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.
Dean R Artis, Jack J Lin, Chao Zhang, Weiru Wang, Upasana Mehra, James F Tobin

Proc Natl Acad Sci U S A· January 2009

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Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.
Zhao-Kui Wan, Jinbo Lee, Rajeev Hotchandani, Alessandro Moretto, Eva Binnun, James F Tobin

ChemMedChem· October 2008

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Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2.
Jingsong Cao, Dandan Shan, Tracy Revett, Dongmei Li, Leeying Wu, James F Tobin

J Biol Chem· July 2008

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Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
Jason Xiang, Zhao-Kui Wan, Huan-Qiu Li, Manus Ipek, Eva Binnun, James Tobin

J Med Chem· July 2008

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Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Douglas P Wilson, Zhao-Kui Wan, Wei-Xin Xu, Steven J Kirincich, Bruce C Follows, James Tobin

J Med Chem· September 2007

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beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.
Jason Xiang, Manus Ipek, Vipin Suri, May Tam, Yuzhe Xing, James Tobin

Bioorg Med Chem· July 2007

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An enzyme-linked immunosorbent assay to measure insulin receptor dephosphorylation by PTP1B.
Yan-Ling Zhang, May Tam, Steve Kirincich, Zhao-Kui Wan, Doug Wilson, James F Tobin

Anal Biochem· June 2007

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Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39.
Frédéric Tremblay, Mylène Perreault, Lori D Klaman, James F Tobin, Erica Smith

Endocrinology· February 2007

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Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis.
Jingsong Cao, Jian-Liang Li, Dongmei Li, James F Tobin, Ruth E Gimeno

Proc Natl Acad Sci U S A· December 2006

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Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists.
David V Erbe, Katherine Gartrell, Yan-Ling Zhang, Vipin Suri, Steven J Kirincich, James F Tobin

Vascul Pharmacol· September 2006

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Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy.
James F Tobin, Leonard P Freedman

Trends Endocrinol Metab· September 2006

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A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.
Alex Clop, Fabienne Marcq, Haruko Takeda, Dimitri Pirottin, Xavier Tordoir, James Tobin

Nat Genet· July 2006

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Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease.
James F Tobin, Anthony J Celeste

Drug Discov Today· May 2006

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Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.
James F Tobin, Anthony J Celeste

Curr Opin Pharmacol· June 2005

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Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Jason Xiang, Manus Ipek, Vipin Suri, Walt Massefski, Ning Pan, James F Tobin

Bioorg Med Chem Lett· June 2005

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