Publications by authors named "Jason Manro"

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Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer.
Shripad V Bhagwat, Cecilia Mur, Matthew Vandekopple, Baohui Zhao, Weihua Shen, Jason R Manro

Cancer Res· February 2025

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Treatment with a VEGFR-2 antibody results in intra-tumor immune modulation and enhances anti-tumor efficacy of PD-L1 blockade in syngeneic murine tumor models.
Yanxia Li, Nelusha Amaladas, Marguerita O'Mahony, Jason R Manro, Ivan Inigo

PLoS One· July 2022

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Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies.
Mathilde Poussin, Arlene Sereno, Xiufeng Wu, Flora Huang, Jason Manro

J Immunother Cancer· July 2021

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ERK Inhibitor LY3214996-Based Treatment Strategies for -Driven Lung Cancer.
Jens Köhler, Yutong Zhao, Jiaqi Li, Prafulla C Gokhale, Hong L Tiv, Jason R Manro

Mol Cancer Ther· April 2021

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ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine.
Shripad V Bhagwat, William T McMillen, Shufen Cai, Baohui Zhao, Matthew Whitesell, Jason Manro

Mol Cancer Ther· February 2020

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The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy.
David A Schaer, Sandaruwan Geeganage, Nelusha Amaladas, Zhao Hai Lu, Erik R Rasmussen, Jason R Manro

Clin Cancer Res· December 2019

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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy.
Jian Du, Lei Yan, Raquel Torres, Xueqian Gong, Huimin Bian, Jason R Manro

Mol Cancer Ther· December 2019

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Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition.
Anthony S Fischl, Xiaoen Wang, Beverly L Falcon, Rowena Almonte-Baldonado, Diane Bodenmiller, Jason Manro

Mol Cancer Ther· April 2019

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MET-targeting antibody (emibetuzumab) and kinase inhibitor (merestinib) as single agent or in combination in a cancer model bearing MET exon 14 skipping.
S Betty Yan, Suzane L Um, Victoria L Peek, Jennifer R Stephens, Wei Zeng, Jason R Manro

Invest New Drugs· August 2018

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Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.
Rikke B Holmgaard, David A Schaer, Yanxia Li, Stephen P Castaneda, Mary Y Murphy, Jason R Manro

J Immunother Cancer· June 2018

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Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor.
Jonathan M Yingling, William T McMillen, Lei Yan, Huocong Huang, J Scott Sawyer, Jason R Manro

Oncotarget· January 2018

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LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.
Eliza Vakana, Susan Pratt, Wayne Blosser, Michele Dowless, Nicholas Simpson, Jason Manro

Oncotarget· February 2017

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Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
Jennifer M Atkinson, Kenneth B Rank, Yi Zeng, Andrew Capen, Vipin Yadav, Jason R Manro

PLoS One· January 2016

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LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth.
Ling Liu, Wei Zeng, Mark A Wortinger, S Betty Yan, Paul Cornwell, Jason R Manro

Clin Cancer Res· December 2014

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Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.
J William Higgins, Jing Q Bao, Alice B Ke, Jason R Manro, John K Fallon

Drug Metab Dispos· January 2014

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Inhibition of tumor growth and metastasis in non-small cell lung cancer by LY2801653, an inhibitor of several oncokinases, including MET.
Wenjuan Wu, Chen Bi, Kelly M Credille, Jason R Manro, Victoria L Peek

Clin Cancer Res· October 2013

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LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
S Betty Yan, Victoria L Peek, Rose Ajamie, Sean G Buchanan, Jeremy R Graff, Jason R Manro

Invest New Drugs· August 2013

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Preclinical bridging studies: understanding dried blood spot and plasma exposure profiles.
Enaksha R Wickremsinhe, Naijia H Huang, Basira G Abdul, Kirk Knotts, Kenneth J Ruterbories, Jason R Manro

Bioanalysis· January 2013

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How well do lipophilicity parameters, MEEKC microemulsion capacity factor, and plasma protein binding predict CNS tissue binding?
Maciej J Zamek-Gliszczynski, Karen E Sprague, Alfonso Espada, Thomas J Raub, Stuart M Morton, Jason R Manro

J Pharm Sci· May 2012

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Patient-derived acute myeloid leukemia (AML) bone marrow cells display distinct intracellular kinase phosphorylation patterns.
Keith Shults, Leanne Flye, Lisa Green, Thomas Daly, Jason R Manro

Cancer Manag Res· May 2009

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Pharmacological characterization of cGMP regulation by the biarylpropylsulfonamide class of positive, allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
John W Ryder, Julie F Falcone, Jason R Manro, Kjell A Svensson, Kalpana M Merchant

J Pharmacol Exp Ther· October 2006

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Developmental expression of human hepatic CYP2C9 and CYP2C19.
Sevasti B Koukouritaki, Jason R Manro, Sandra A Marsh, Jeffrey C Stevens, Allan E Rettie

J Pharmacol Exp Ther· March 2004

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Developmental expression of the major human hepatic CYP3A enzymes.
Jeffrey C Stevens, Ronald N Hines, Chungang Gu, Sevasti B Koukouritaki, Jason R Manro

J Pharmacol Exp Ther· November 2003

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