Publications by authors named "Jay Strum"

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Correction: INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors.
Catherine Dietrich, Alec Trub, Antonio Ahn, Michael Taylor, Krutika Ambani, Jay Strum

Cancer Discov· October 2025

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Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle.
Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P Dommer, Jay Strum

Nat Commun· February 2025

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INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors.
Catherine Dietrich, Alec Trub, Antonio Ahn, Michael Taylor, Krutika Ambani, Jay Strum

Cancer Discov· March 2024

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CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy.
Anne Y Lai, Jessica A Sorrentino, Konstantin H Dragnev, Jared M Weiss, Taofeek K Owonikoko, Jay C Strum

J Immunother Cancer· October 2020

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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
Kaitlyn J Andreano, Suzanne E Wardell, Jennifer G Baker, Taylor K Desautels, Robert Baldi, Jay C Strum

Breast Cancer Res Treat· April 2020

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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.
Jiehui Deng, Eric S Wang, Russell W Jenkins, Shuai Li, Ruben Dries, Jay C Strum

Cancer Discov· February 2018

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CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.
James P Stice, Suzanne E Wardell, John D Norris, Alexander P Yllanes, Holly M Alley, Jay C Strum

Mol Cancer Res· June 2017

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Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.
John E Bisi, Jessica A Sorrentino, Jamie L Jordan, David D Darr, Patrick J Roberts, Jay C Strum

Oncotarget· June 2017

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Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.
Shenghui He, Patrick J Roberts, Jessica A Sorrentino, John E Bisi, Hannah Storrie-White, Jay C Strum

Sci Transl Med· April 2017

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Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression.
John E Bisi, Jessica A Sorrentino, Patrick J Roberts, Francis X Tavares, Jay C Strum

Mol Cancer Ther· May 2016

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CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury.
Derek P DiRocco, John Bisi, Patrick Roberts, Jay Strum, Kwok-Kin Wong

Am J Physiol Renal Physiol· February 2014

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Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.
Patrick J Roberts, John E Bisi, Jay C Strum, Austin J Combest, David B Darr

J Natl Cancer Inst· March 2012

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Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes.
James X Rong, Jean-Louis D Klein, Yang Qiu, Mi Xie, Jennifer H Johnson, Jay C Strum

PPAR Res· November 2011

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MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1.
Jay C Strum, Jennifer H Johnson, James Ward, Hongbo Xie, John Feild

Mol Endocrinol· November 2009

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GSK983: a novel compound with broad-spectrum antiviral activity.
Robert Harvey, Kevin Brown, Qin Zhang, Margaret Gartland, Leslie Walton, Jay Strum

Antiviral Res· April 2009

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Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.
Ulf Risérus, Dennis Sprecher, Tony Johnson, Eric Olson, Sandra Hirschberg, Jay C Strum

Diabetes· February 2008

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Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone.
James X Rong, Yang Qiu, Michael K Hansen, Lei Zhu, Vivian Zhang, Jay C Strum

Diabetes· July 2007

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Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.
Melanie J Robbins, Kathryn R Starr, Andy Honey, Ellen M Soffin, Claire Rourke, Jay Strum

Brain Res· June 2007

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Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles.
Priti S Hegde, David Rusnak, Melissa Bertiaux, Krystal Alligood, Jay Strum

Mol Cancer Ther· May 2007

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Rosiglitazone induces mitochondrial biogenesis in mouse brain.
Jay C Strum, Ron Shehee, David Virley, Jill Richardson, Michael Mattie

J Alzheimers Dis· March 2007

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Automated solutions for total RNA isolation from diverse sample types.
Paula Selley, Jimmy Bruner, Fiona Kelly, Frank Maurio, Michelle Waters, Jay Strum

Clin Lab Med· March 2007

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A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.
Wenle Xia, Sarah Bacus, Priti Hegde, Intisar Husain, Jay Strum

Proc Natl Acad Sci U S A· May 2006

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Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
Baichun Yang, Lihong Chen, Ying Qian, James A Triantafillou, Judi A McNulty, Jay Strum

Biochem Biophys Res Commun· March 2006

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Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.
Wenle Xia, John Bisi, Jay Strum, Leihua Liu, Kevin Carrick

Cancer Res· February 2006

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PPARgamma agonists diminish serum VEGF elevation in diet-induced insulin resistant SD rats and ZDF rats.
Baichun Yang, Peiyuan Lin, Kevin M Carrick, Judi A McNulty, Lisa G Clifton, Jay C Strum

Biochem Biophys Res Commun· August 2005

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