Publications by authors named "Jay Theroff"

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Matthew M Hamilton, Faika Mseeh, Timothy J McAfoos, Paul G Leonard, Naphtali J Reyna, Jay P Theroff

J Med Chem· August 2021

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Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
Michael J Soth, Kang Le, Maria Emilia Di Francesco, Matthew M Hamilton, Gang Liu, Jay Theroff

J Med Chem· November 2020

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An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
Jennifer R Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi, Jay Theroff

Nat Med· July 2018

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Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
Wylie S Palmer, Guillaume Poncet-Montange, Gang Liu, Alessia Petrocchi, Naphtali Reyna, Jay Theroff

J Med Chem· February 2016

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Design, synthesis, and biological evaluation of sulfonyl acrylonitriles as novel inhibitors of cancer metastasis and spread.
Yi Shen, Craig A Zificsak, Jill E Shea, Xuegang Lao, Oana Bollt, Jay P Theroff

J Med Chem· February 2015

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Improvement of inhibitor identification for heat shock protein 90α by utilizing a red-shifted fluorescence polarization probe.
Jie Qian, Beverly P Holskin, Jay Theroff, Ted Underiner, Sheryl L Meyer

Assay Drug Dev Technol· August 2012

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Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis.
Craig A Zificsak, Yi Shen, Joseph G Lisko, Jay P Theroff, Xuegang Lao

Bioorg Med Chem Lett· March 2012

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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.
Craig A Zificsak, Diane E Gingrich, Henry J Breslin, Derek D Dunn, Karen L Milkiewicz, Jay P Theroff

Bioorg Med Chem Lett· January 2012

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Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors.
Craig A Zificsak, Jay P Theroff, Lisa D Aimone, Thelma S Angeles, Mark S Albom

Bioorg Med Chem Lett· July 2011

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Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors.
Linda R Weinberg, Mark S Albom, Thelma S Angeles, Jean Husten, Joseph G Lisko, Jay P Theroff

Bioorg Med Chem Lett· January 2011

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2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines.
Craig A Zificsak, Jay P Theroff, Lisa D Aimone, Mark S Albom, Thelma S Angeles

Bioorg Med Chem Lett· January 2011

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Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase.
Karen L Milkiewicz, Linda R Weinberg, Mark S Albom, Thelma S Angeles, Mangeng Cheng, Jay P Theroff

Bioorg Med Chem· June 2010

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Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors.
Jeffrey G Varnes, Dean A Wacker, Donald J P Pinto, Michael J Orwat, Jay P Theroff

Bioorg Med Chem Lett· January 2008

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