Publications by authors named "Jeff D Reagan"

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Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics.
Huamei He, Tomas Baka, James Balschi, Alykhan S Motani, Kathy K Nguyen, Jeff D Reagan

Circ Heart Fail· March 2022

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Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.
Wei Wang, Liyan Zhang, Pavan K Battiprolu, Arata Fukushima, Khanh Nguyen, Jeff D Reagan

JACC Basic Transl Sci· June 2019

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Discovery and pharmacological effects of a novel GPR142 antagonist.
Michiko Murakoshi, Harumi Kuwabara, Miyuki Nagasaki, Yu Mei Xiong, Jeff D Reagan

J Recept Signal Transduct Res· June 2017

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Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.
Paul M Wehn, Paul E Harrington, Timothy J Carlson, James Davis, Pierre Deprez, Jeff D Reagan

Bioorg Med Chem Lett· December 2013

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Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.
Ming Yu, Mike Lizarzaburu, Alykhan Motani, Zice Fu, Xiaohui Du, Jeff D Reagan

ACS Med Chem Lett· September 2013

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Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.
Narihiro Toda, Xiaolin Hao, Yasuyuki Ogawa, Kozo Oda, Ming Yu, Jeff D Reagan

ACS Med Chem Lett· August 2013

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Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.
Xiaohui Du, Yong-Jae Kim, Sujen Lai, Xi Chen, Mike Lizarzaburu, Jeff D Reagan

Bioorg Med Chem Lett· October 2012

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GPR35 is a target of the loop diuretic drugs bumetanide and furosemide.
Yuhua Yang, Angela Fu, Xiaosu Wu, Jeff D Reagan

Pharmacology· July 2012

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AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents.
Daniel C-H Lin, Jane Zhang, Run Zhuang, Frank Li, Kathy Nguyen, Jeff D Reagan

PLoS One· May 2012

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AMG 837: a potent, orally bioavailable GPR40 agonist.
Jonathan B Houze, Liusheng Zhu, Ying Sun, Michelle Akerman, Wei Qiu, Jeff D Reagan

Bioorg Med Chem Lett· January 2012

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Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion.
Charles Henley, Yuhua Yang, James Davis, Jenny Ying Lin Lu, Sean Morony, Jeff D Reagan

J Pharmacol Exp Ther· June 2011

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G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium.
Yuhua Yang, Jenny Ying-Lin Lu, Xiaosu Wu, Shamin Summer, John Whoriskey, Jeff D Reagan

Pharmacology· December 2010

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The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.
Paul E Harrington, David J St Jean, Jeffrey Clarine, Thomas S Coulter, Michael Croghan, Jeff D Reagan

Bioorg Med Chem Lett· September 2010

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Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor.
Jenny Ying Lin Lu, Yuhua Yang, Gilles Gnacadja, Arthur Christopoulos, Jeff D Reagan

J Pharmacol Exp Ther· December 2009

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Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics.
Steve F Poon, David J St Jean, Paul E Harrington, Charles Henley, James Davis, Jeff D Reagan

J Med Chem· November 2009

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Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands.
Peter Coward, Marion Conn, Jie Tang, Fei Xiong, Anthony Menjares, Jeff D Reagan

Anal Biochem· January 2009

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The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist.
Hua Tang, Jenny Ying-Lin Lu, Xiaomu Zheng, Yuhua Yang, Jeff D Reagan

Biochem Biophys Res Commun· October 2008

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Elucidation of signaling and functional activities of an orphan GPCR, GPR81.
Hongfei Ge, Jennifer Weiszmann, Jeff D Reagan, Jamila Gupte, Helene Baribault

J Lipid Res· April 2008

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High throughput screening for orphan and liganded GPCRs.
Shou-Hua Xiao, Jeff D Reagan, Paul H Lee, Angela Fu, Ralf Schwandner

Comb Chem High Throughput Screen· March 2008

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