Publications by authors named "Jeffrey R Jackson"

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An immune-active tumor microenvironment favors clinical response to ipilimumab.
Rui-Ru Ji, Scott D Chasalow, Lisu Wang, Omid Hamid, Henrik Schmidt, Jeffrey R Jackson

Cancer Immunol Immunother· July 2012

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Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab.
Vafa Shahabi, Gena Whitney, Omid Hamid, Henrik Schmidt, Scott D Chasalow, Jeffrey R Jackson

Cancer Immunol Immunother· May 2012

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Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties.
Tara R Rheault, Kelly H Donaldson, Jennifer G Badiang-Alberti, Ronda G Davis-Ward, C Webb Andrews, Jeffrey R Jackson

Bioorg Med Chem Lett· August 2010

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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.
Xiangping Qian, Andrew McDonald, Han-Jie Zhou, Nicholas D Adams, Cynthia A Parrish, Jeffrey R Jackson

ACS Med Chem Lett· April 2010

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
Steven D Knight, Nicholas D Adams, Joelle L Burgess, Amita M Chaudhari, Michael G Darcy, Jeffrey R Jackson

ACS Med Chem Lett· April 2010

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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.
Kenneth W Wood, Latesh Lad, Lusong Luo, Xiangping Qian, Steven D Knight, Jeffrey R Jackson

Proc Natl Acad Sci U S A· March 2010

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Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.
Aidan G Gilmartin, Maureen R Bleam, Mark C Richter, Symon G Erskine, Ryan G Kruger, Jeffrey R Jackson

Cancer Res· September 2009

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Integrated analysis of breast cancer cell lines reveals unique signaling pathways.
Laura M Heiser, Nicholas J Wang, Carolyn L Talcott, Keith R Laderoute, Merrill Knapp, Jeffrey R Jackson

Genome Biol· July 2009

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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
Kyle A Emmitte, George M Adjabeng, C Webb Andrews, Jennifer G Badiang Alberti, Ramesh Bambal, Jeffrey R Jackson

Bioorg Med Chem Lett· March 2009

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Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint.
Kenneth W Wood, Penelope Chua, David Sutton, Jeffrey R Jackson

Clin Cancer Res· December 2008

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Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.
Lusong Luo, Jeffrey D Carson, Kathleen S Molnar, Steven J Tuske, Stephen J Coales, Jeffrey R Jackson

J Am Chem Soc· June 2008

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ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Lusong Luo, Cynthia A Parrish, Neysa Nevins, Dean E McNulty, Amita M Chaudhari, Jeffrey R Jackson

Nat Chem Biol· November 2007

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Novel ATP-competitive kinesin spindle protein inhibitors.
Cynthia A Parrish, Nicholas D Adams, Kurt R Auger, Joelle L Burgess, Jeffrey D Carson, Jeffrey R Jackson

J Med Chem· October 2007

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Targeted anti-mitotic therapies: can we improve on tubulin agents?
Jeffrey R Jackson, Denis R Patrick, Mohammed M Dar, Pearl S Huang

Nat Rev Cancer· February 2007

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Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition.
Lusong Luo, Jeffrey D Carson, Dashyant Dhanak, Jeffrey R Jackson, Pearl S Huang

Biochemistry· December 2004

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G2 checkpoint control: checking in to the last resort for DNA damage.
Jeffrey R Jackson, Bin-Bing Zhou

Cancer Biol Ther· March 2004

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The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore.
Christopher S Stevenson, Elizabeth A Capper, Amy K Roshak, Brian Marquez, Chris Eichman, Jeffrey R Jackson

J Pharmacol Exp Ther· November 2002

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Identification of Drosophila Myt1 kinase and its role in Golgi during mitosis.
William D Cornwell, Paula J Kaminski, Jeffrey R Jackson

Cell Signal· May 2002

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Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts.
Boyd B Scott, Paola F Zaratin, Antonio Colombo, Michael J Hansbury, James D Winkler, Jeffrey R Jackson

J Rheumatol· February 2002

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