Publications by authors named "John D McCarter"

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Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter

Nat Cancer· January 2024

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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Nuria A Tamayo, Matthew P Bourbeau, Jennifer R Allen, Kate S Ashton, Jian Jeffrey Chen, John D McCarter

J Med Chem· March 2022

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Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS).
Aniruddha Sahasrabuddhe, Dylan Oakley, Kui Chen, John D McCarter

SLAS Discov· February 2021

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Systematic Study of the Glutathione Reactivity of -Phenylacrylamides: 2. Effects of Acrylamide Substitution.
Adam Birkholz, David J Kopecky, Laurie P Volak, Michael D Bartberger, Yuping Chen, John D McCarter

J Med Chem· October 2020

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Discovery of a Covalent Inhibitor of KRAS (AMG 510) for the Treatment of Solid Tumors.
Brian A Lanman, Jennifer R Allen, John G Allen, Albert K Amegadzie, Kate S Ashton, John D McCarter

J Med Chem· January 2020

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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Jude Canon, Karen Rex, Anne Y Saiki, Christopher Mohr, Keegan Cooke, John D McCarter

Nature· November 2019

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A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation.
Ryan P Wurz, Ken Dellamaggiore, Hannah Dou, Noelle Javier, Mei-Chu Lo, John D McCarter

J Med Chem· January 2018

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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
John G Allen, Mirna Mujacic, Michael J Frohn, Alex J Pickrell, Paul Kodama, John D McCarter

ACS Chem Biol· October 2016

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High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow.
Iain D G Campuzano, Tisha San Miguel, Todd Rowe, Daniel Onea, Victor J Cee, John D McCarter

J Biomol Screen· February 2016

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Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures.
Zhimei Du, David Treiber, John D McCarter, Dina Fomina-Yadlin, Ramsey A Saleem

Biotechnol Bioeng· January 2015

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Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
Timothy D Cushing, Xiaolin Hao, Youngsook Shin, Kristin Andrews, Matthew Brown, John D McCarter

J Med Chem· January 2015

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Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Brian A Lanman, Anthony B Reed, Victor J Cee, Fang-Tsao Hong, Liping H Pettus, John D McCarter

Bioorg Med Chem Lett· December 2014

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Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, Chester Yuan, Albert Amegadzie, John D McCarter

Bioorg Med Chem Lett· December 2013

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Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay.
Ada Chen, Xiaoning Zhao, Laina Mercer, Cheng Su, Leeanne Zalameda, John D McCarter

Comb Chem High Throughput Screen· September 2013

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IgG1 thioether bond formation in vivo.
Qingchun Zhang, Matthew R Schenauer, John D McCarter, Gregory C Flynn

J Biol Chem· June 2013

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Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Ryan P Wurz, Longbin Liu, Kevin Yang, Nobuko Nishimura, Yunxin Bo, John D McCarter

Bioorg Med Chem Lett· September 2012

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Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
Mark H Norman, Kristin L Andrews, Yunxin Y Bo, Shon K Booker, Sean Caenepeel, John D McCarter

J Med Chem· September 2012

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Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
Adrian L Smith, Noel D D'Angelo, Yunxin Y Bo, Shon K Booker, Victor J Cee, John D McCarter

J Med Chem· June 2012

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Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors.
David Meininger, Leeanne Zalameda, Yichin Liu, Lara P Stepan, Luis Borges, John D McCarter

Biochim Biophys Acta· December 2011

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Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides.
Seung Seo Lee, Ian R Greig, David J Vocadlo, John D McCarter, Brian O Patrick

J Am Chem Soc· October 2011

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Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.
Noel D D'Angelo, Tae-Seong Kim, Kristin Andrews, Shon K Booker, Sean Caenepeel, John D McCarter

J Med Chem· March 2011

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Inhibitors of the lipid phosphatase SHIP2 discovered by high-throughput affinity selection-mass spectrometry screening of combinatorial libraries.
D Allen Annis, Cliff C Cheng, Cheng-Chi Chuang, John D McCarter, Huw M Nash

Comb Chem High Throughput Screen· September 2009

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Editorial [Hot topic: Label-free detection technologies (Guest editor: John D. McCarter)].
John D McCarter

Comb Chem High Throughput Screen· September 2009

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High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay.
Yichin Liu, Raphaele Gerber, John Wu, Trace Tsuruda, John D McCarter

Anal Biochem· July 2008

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Synthesis and testing of 2-deoxy-2,2-dihaloglycosides as mechanism-based inhibitors of alpha-glycosidases.
Ran Zhang, John D McCarter, Curtis Braun, Wai Yeung, Gary D Brayer

J Org Chem· April 2008

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