Publications by authors named "Jonathan O'Connell"

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USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Jonathan O'Connell

Elife· October 2021

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One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.
Juergen Ramharter, Dirk Kessler, Peter Ettmayer, Marco H Hofmann, Thomas Gerstberger, Jonathan C O'Connell

J Med Chem· May 2021

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The deubiquitylase USP9X controls ribosomal stalling.
Anne Clancy, Claire Heride, Adán Pinto-Fernández, Hannah Elcocks, Andreas Kallinos, Jonathan O'Connell

J Cell Biol· March 2021

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Correction: The deubiquitylase USP9X controls ribosomal stalling.
Anne Clancy, Claire Heride, Adán Pinto-Fernández, Hannah Elcocks, Andreas Kallinos, Jonathan O'Connell

J Cell Biol· March 2021

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Marco H Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Jonathan C O'Connell

Cancer Discov· January 2021

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The Impact of Variable Selection Coverage on Detection of Ligands from a DNA-Encoded Library Screen.
Kelly A McCarthy, G Joseph Franklin, David R Lancia, Martin Olbrot, Eneida Pardo, Jonathan C O'Connell

SLAS Discov· June 2020

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Synthesis of Multifunctional 2-Aminobenzimidazoles on DNA via Iodine-Promoted Cyclization.
Liqiang Su, Jing Feng, Ting Peng, Jinqiao Wan, Jing Fan, Jonathan O'Connell

Org Lett· February 2020

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Challenges and Opportunities in Enabling High-Throughput, Miniaturized High Content Screening.
Debra Nickischer, Lisa Elkin, Normand Cloutier, Jonathan O'Connell, Martyn Banks

Methods Mol Biol· June 2018

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Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
Andrew Alt, Annapurna Pendri, Robert L Bertekap, Guo Li, Yulia Benitex, Jonathan O'Connell

J Pharmacol Exp Ther· February 2016

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Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.
Neil T Burford, Kathryn E Livingston, Meritxell Canals, Molly R Ryan, Lauren M L Budenholzer, Jonathan O'Connell

J Med Chem· May 2015

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Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen.
Neil T Burford, Tom Wehrman, Daniel Bassoni, Jonathan O'Connell, Martyn Banks

J Biomol Screen· October 2014

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Integrating High-Content Analysis into a Multiplexed Screening Approach to Identify and Characterize GPCR Agonists.
Yingjie Zhu, John Watson, Mengjie Chen, Ding Ren Shen, Melissa Yarde, Jonathan O'Connell

J Biomol Screen· August 2014

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Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.
Shuang Liu, Congxiang Zha, Kassoum Nacro, Min Hu, Wenge Cui, Jonathan O'Connell

ACS Med Chem Lett· July 2014

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Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity.
Kingsley K Appiah, Yuval Blat, Barbara J Robertson, Bradley C Pearce, Donna L Pedicord, Jonathan C O'Connell

J Biomol Screen· April 2014

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Development of novel, 384-well high-throughput assay panels for human drug transporters: drug interaction and safety assessment in support of discovery research.
Huaping Tang, Ding Ren Shen, Yong-Hae Han, Yan Kong, Praveen Balimane, Jonathan C O'Connell

J Biomol Screen· October 2013

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.
Neil T Burford, Mary J Clark, Tom S Wehrman, Samuel W Gerritz, Martyn Banks, Jonathan O'Connell

Proc Natl Acad Sci U S A· June 2013

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Development of a high-throughput calcium flux assay for identification of all ligand types including positive, negative, and silent allosteric modulators for G protein-coupled receptors.
Devin J Noblin, Robert L Bertekap, Neil T Burford, Adam Hendricson, Litao Zhang, Jonathan O'Connell

Assay Drug Dev Technol· October 2012

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Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
Steven Sheriff, Brett R Beno, Weixu Zhai, Walter A Kostich, Patricia A McDonnell, Jonathan O'Connell

J Med Chem· October 2011

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A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors.
Kingsley K Appiah, Walter A Kostich, Samuel W Gerritz, Yanling Huang, Brian D Hamman, Jonathan C O'Connell

J Biomol Screen· June 2011

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2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.
Lalgudi S Harikrishnan, Muthoni G Kamau, Timothy F Herpin, George C Morton, Yalei Liu, Jonathan C O'Connell

Bioorg Med Chem Lett· April 2008

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Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006.
John G Houston, Martyn N Banks, Alastair Binnie, Stephen Brenner, Jonathan O'Connell

Drug Discov Today· January 2008

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Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay.
Zhengrong Zhu, Jaime Puglisi, David Connors, Jeremy Stewart, John Herbst, Jonathan O'Connell

J Biomol Screen· March 2007

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