Publications by authors named "Melissa Yarde"

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Plasma biomarkers associated with adverse outcomes in patients with calcific aortic stenosis.
Mahesh K Vidula, Alena Orlenko, Lei Zhao, Lisa Salvador, Aeron M Small, Melissa Yarde

Eur J Heart Fail· December 2021

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BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.
Robert J Cherney, Prakash Anjanappa, Kumaravel Selvakumar, Douglas G Batt, Gregory D Brown, Melissa Yarde

ACS Med Chem Lett· November 2021

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Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice.
Shahid Tannu, John Allocco, Melissa Yarde, Pancras Wong, Xiuying Ma

J Pharmacol Toxicol Methods· August 2021

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Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists.
Zheming Ruan, Peter K Park, Donna Wei, Ashok Purandare, Honghe Wan, Melissa Yarde

Bioorg Med Chem Lett· March 2021

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Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
Michael G Yang, Myra Beaudoin-Bertrand, Zili Xiao, David Marcoux, Carolyn A Weigelt, Melissa Yarde

J Med Chem· March 2021

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Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.
Qing Shi, Zili Xiao, Michael G Yang, David Marcoux, Robert J Cherney, Melissa Yarde

Bioorg Med Chem Lett· December 2020

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Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.
Qingjie Liu, Douglas G Batt, Carolyn A Weigelt, Shiuhang Yip, Dauh-Rurng Wu, Melissa Yarde

ACS Med Chem Lett· December 2020

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Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable RORγt inverse agonists.
James J-W Duan, Bin Jiang, Zhonghui Lu, Sylwia Stachura, Carolyn A Weigelt, Melissa Yarde

Bioorg Med Chem Lett· October 2020

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Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists.
David Marcoux, Myra Beaudoin Bertrand, Carolyn A Weigelt, Shiuhang Yip, Michael Galella, Melissa Yarde

Bioorg Med Chem Lett· October 2020

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Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists.
Bin Jiang, James J-W Duan, Sylwia Stachura, Ananta Karmakar, Hemalatha Hemagiri, Melissa Yarde

Bioorg Med Chem Lett· September 2020

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Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.
Lalgudi S Harikrishnan, Patrice Gill, Muthoni G Kamau, Lan-Ying Qin, Zheming Ruan, Melissa Yarde

Bioorg Med Chem Lett· June 2020

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Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.
Robert J Cherney, Lyndon A M Cornelius, Anurag Srivastava, Carolyn A Weigelt, David Marcoux, Melissa Yarde

ACS Med Chem Lett· June 2020

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Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease.
Alexander P Kossar, Wanda Anselmo, Juan B Grau, Yichuan Liu, Aeron Small, Melissa Yarde

Physiol Genomics· April 2020

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Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone.
Jordana B Cohen, Sarah J Schrauben, Lei Zhao, Michael D Basso, Mary Ellen Cvijic, Melissa Yarde

JACC Heart Fail· March 2020

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Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction.
Julio A Chirinos, Alena Orlenko, Lei Zhao, Michael D Basso, Mary Ellen Cvijic, Melissa Yarde

J Am Coll Cardiol· March 2020

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Effect of Serum Albumin Levels in Patients With Heart Failure With Preserved Ejection Fraction (from the TOPCAT Trial).
Stuart B Prenner, Anupam Kumar, Lei Zhao, Mary E Cvijic, Michael Basso, Melissa Yarde

Am J Cardiol· February 2020

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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
David Marcoux, James J-W Duan, Qing Shi, Robert J Cherney, Anurag S Srivastava, Melissa Yarde

J Med Chem· November 2019

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Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.
Zhonghui Lu, James J-W Duan, Haiyun Xiao, James Neels, Dauh-Rurng Wu, Melissa Yarde

Bioorg Med Chem Lett· August 2019

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Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.
James J-W Duan, Zhonghui Lu, Bin Jiang, Sylwia Stachura, Carolyn A Weigelt, Melissa Yarde

ACS Med Chem Lett· March 2019

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Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.
Sumanta Mukherjee, Leonid Zhelnin, Anthony Sanfiz, Jie Pan, Zhuyin Li, Melissa Yarde

Am J Transl Res· March 2019

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Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Hua Gong, David S Weinstein, Zhonghui Lu, James J-W Duan, Sylwia Stachura, Melissa Yarde

Bioorg Med Chem Lett· January 2018

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Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
Qingjie Liu, Qing Shi, David Marcoux, Douglas G Batt, Lyndon Cornelius, Melissa Yarde

J Med Chem· June 2017

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Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P) Employing Ligand-Based Drug Design.
Hai-Yun Xiao, Scott H Watterson, Charles M Langevine, Anurag S Srivastava, Soo S Ko, Melissa Yarde

J Med Chem· November 2016

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384-Well Multiplexed Luminex Cytokine Assays for Lead Optimization.
Huaping Tang, Reshma Panemangalore, Melissa Yarde, Litao Zhang, Mary Ellen Cvijic

J Biomol Screen· July 2016

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Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
John L Gilmore, James E Sheppeck, Scott H Watterson, Lauren Haque, Parag Mukhopadhyay, Melissa Yarde

J Med Chem· July 2016

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