Publications by authors named "Tom Wehrman"

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A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan Receptors.
Camilo J Morfa, Daniel Bassoni, Andras Szabo, Danielle McAnally, Haleli Sharir, Tom Wehrman

Assay Drug Dev Technol· October 2018

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Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.
Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman

Elife· May 2017

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Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Chia Chi M Ho, Akanksha Chhabra, Philipp Starkl, Peter-John Schnorr, Stephan Wilmes, Tom S Wehrman

Cell· March 2017

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Rapid, Antibody-Free Detection of Recombinant Proteins on Blots Using Enzyme Fragment Complementation.
Neil W Charter, Joe Horecka, Chin-Yee Loh, Albert Doan, Tom Wehrman

Methods Mol Biol· March 2016

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Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.
Neil T Burford, Kathryn E Livingston, Meritxell Canals, Molly R Ryan, Lauren M L Budenholzer, Tom S Wehrman

J Med Chem· May 2015

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Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.
Ignacio Moraga, Gerlinde Wernig, Stephan Wilmes, Vitalina Gryshkova, Christian P Richter, Tom S Wehrman

Cell· March 2015

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Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen.
Neil T Burford, Tom Wehrman, Daniel Bassoni, Jonathan O'Connell, Martyn Banks

J Biomol Screen· October 2014

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Biased agonism as a mechanism for differential signaling by chemokine receptors.
Sudarshan Rajagopal, Daniel L Bassoni, James J Campbell, Norma P Gerard, Craig Gerard, Tom S Wehrman

J Biol Chem· December 2013

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Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.
Craig Southern, Jennifer M Cook, Zaynab Neetoo-Isseljee, Debra L Taylor, Catherine A Kettleborough, Tom S Wehrman

J Biomol Screen· June 2013

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.
Neil T Burford, Mary J Clark, Tom S Wehrman, Samuel W Gerritz, Martyn Banks

Proc Natl Acad Sci U S A· June 2013

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EphB4 cellular kinase activity assayed using an enzymatic protein interaction system.
Tom Wehrman, Mimi Nguyen, Wei Feng, Benjamin Bader

Assay Drug Dev Technol· May 2013

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Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways.
Janet J Maguire, Rhoda E Kuc, Victoria R Pell, Andrew Green, Mike Brown, Tom Wehrman

Life Sci· October 2012

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Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays.
Daniel L Bassoni, Qumber Jafri, Sunitha Sastry, Mahesh Mathrubutham, Tom S Wehrman

Methods Mol Biol· October 2012

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Measurements of β-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation.
Daniel L Bassoni, William J Raab, Philip L Achacoso, Chin Yee Loh, Tom S Wehrman

Methods Mol Biol· October 2012

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Imaging beta-galactosidase activity in vivo using sequential reporter-enzyme luminescence.
Georges von Degenfeld, Tom S Wehrman, Helen M Blau

Methods Mol Biol· January 2010

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Rapid, antibody-free detection of recombinant proteins on blots using enzyme fragment complementation.
Neil W Charter, Joe Horecka, Chin-Yee Loh, Albert Doan, Tom Wehrman

Methods Mol Biol· June 2009

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A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors.
Xiaoning Zhao, Adrie Jones, Keith R Olson, Kun Peng, Tom Wehrman

J Biomol Screen· September 2008

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A universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals.
Georges von Degenfeld, Tom S Wehrman, Mark M Hammer, Helen M Blau

FASEB J· December 2007

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A novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization.
Mark M Hammer, Tom S Wehrman, Helen M Blau

FASEB J· December 2007

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Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
Tom Wehrman, Xiaolin He, Bill Raab, Abhiram Dukipatti, Helen Blau

Neuron· January 2007

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Enzymatic detection of protein translocation.
Tom S Wehrman, Clayton L Casipit, Nevin M Gewertz, Helen M Blau

Nat Methods· July 2005

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mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage.
George L Sen, Tom S Wehrman, Helen M Blau

Differentiation· July 2005

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Restriction enzyme-generated siRNA (REGS) vectors and libraries.
George Sen, Tom S Wehrman, Jason W Myers, Helen M Blau

Nat Genet· February 2004

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Protein-protein interactions monitored in mammalian cells via complementation of beta -lactamase enzyme fragments.
Tom Wehrman, Benjamin Kleaveland, Jeng-Horng Her, Robert F Balint, Helen M Blau

Proc Natl Acad Sci U S A· March 2002

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