Publications by authors named "Jorg Lippert"

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An Open-Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design.
Abdullah Hamadeh, Moriah Pellowe, Pierre Chelle, Cindy Hoi Ting Yeung, Julian Otalvaro, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· December 2025

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Polycystic ovary syndrome and elevated body mass index independently increase type 2 diabetes risk with obesity-mediated risk dominating: a real-world data analysis of US patients.
Konstantin Sharafutdinov, Jan Hilpert, Rolf Burghaus, Christian Diedrich, Jörg Lippert

Fertil Steril· September 2025

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Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference.
André Dallmann, Denise Feick, Pavel Balazki, Salih Benamara, Rolf Burghaus, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· May 2025

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Model-Informed Drug Development: Steps Toward Harmonized Guidance.
Scott Marshall, Malidi Ahamadi, Jenny Chien, Daisuke Iwata, Pavel Farkas, Jörg Lippert

Clin Pharmacol Ther· November 2023

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Data-driven identification of heart failure disease states and progression pathways using electronic health records.
Tasha Nagamine, Brian Gillette, John Kahoun, Rolf Burghaus, Jörg Lippert

Sci Rep· October 2022

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Model-informed bridging of rivaroxaban doses for thromboprophylaxis in pediatric patients aged 9 years and older with congenital heart disease.
Stefan Willmann, Ibrahim Ince, Maurice Ahsman, Katrin Coboeken, Yang Zhang, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· August 2022

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CKD subpopulations defined by risk-factors: A longitudinal analysis of electronic health records.
Rajagopalan Ramaswamy, Soon Nan Wee, Kavya George, Abhijit Ghosh, Joydeep Sarkar, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· November 2021

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Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically-based pharmacokinetic predictions.
Stefan Willmann, Katrin Coboeken, Yang Zhang, Hannah Mayer, Ibrahim Ince, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· October 2021

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NT-proBNP Qualifies as a Surrogate for Clinical End Points in Heart Failure.
Walter Schmitt, Hauke Rühs, Rolf Burghaus, Christian Diedrich, Sulav Duwal, Jörg Lippert

Clin Pharmacol Ther· August 2021

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Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
Rebekka Fendt, Ute Hofmann, Annika R P Schneider, Elke Schaeffeler, Rolf Burghaus, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· July 2021

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A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions.
Sebastian Frechen, Juri Solodenko, Thomas Wendl, André Dallmann, Ibrahim Ince, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· June 2021

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Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small-Molecule Compounds in Children.
Ibrahim Ince, André Dallmann, Sebastian Frechen, Katrin Coboeken, Christoph Niederalt, Jörg Lippert

J Clin Pharmacol· June 2021

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Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Vijayalakshmi Chelliah, Georgia Lazarou, Sumit Bhatnagar, John P Gibbs, Marjoleen Nijsen, Jörg Lippert

Clin Pharmacol Ther· March 2021

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Multiscale classification of heart failure phenotypes by unsupervised clustering of unstructured electronic medical record data.
Tasha Nagamine, Brian Gillette, Alexey Pakhomov, John Kahoun, Hannah Mayer, Jörg Lippert

Sci Rep· December 2020

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Population Pharmacokinetic and Exposure-Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease.
Nelleke Snelder, Roland Heinig, Henk-Jan Drenth, Amer Joseph, Peter Kolkhof, Jörg Lippert

Clin Pharmacokinet· March 2020

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Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences.
Jörg Lippert, Rolf Burghaus, Andrea Edginton, Sebastian Frechen, Mats Karlsson

CPT Pharmacometrics Syst Pharmacol· December 2019

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Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach.
Priyata Kalra, Julian Brandl, Thomas Gaub, Christoph Niederalt, Jörg Lippert

PLoS One· November 2019

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Application of Physiologically-Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin.
Stefan Willmann, Matthias Frei, Gabriele Sutter, Katrin Coboeken, Thomas Wendl, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· September 2019

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Predictive Pediatric Modeling and Simulation Using Ontogeny Information.
Ibrahim Ince, Juri Solodenko, Sebastian Frechen, André Dallmann, Christoph Niederalt, Jörg Lippert

J Clin Pharmacol· September 2019

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Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study.
Stefan Willmann, Kirstin Thelen, Dagmar Kubitza, Anthonie W A Lensing, Matthias Frede, Jörg Lippert

Thromb J· December 2018

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Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate.
Lawrence J Lesko, Valvanera Vozmediano, Joshua D Brown, Almut Winterstein, Ping Zhao, Jörg Lippert

CPT Pharmacometrics Syst Pharmacol· November 2018

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Smart Medical Information Technology for Healthcare (SMITH).
Alfred Winter, Sebastian Stäubert, Danny Ammon, Stephan Aiche, Oya Beyan, Jörg Lippert

Methods Inf Med· July 2018

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A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.
Christoph Niederalt, Lars Kuepfer, Juri Solodenko, Thomas Eissing, Hans-Ulrich Siegmund, Jörg Lippert

J Pharmacokinet Pharmacodyn· April 2018

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Robust PBPK/PD-Based Model Predictive Control of Blood Glucose.
Stephan Schaller, Jorg Lippert, Lukas Schaupp, Thomas R Pieber, Andreas Schuppert

IEEE Trans Biomed Eng· July 2016

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Modeling and Simulation of In Vivo Drug Effects.
Jörg Lippert, Rolf Burghaus, Lars Kuepfer, Bart Ploeger, Stephan Schaller

Handb Exp Pharmacol· June 2016

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