Publications by authors named "Kevin Foote"

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Synthesis of -allylic sulfinamides by the catalytic nucleophilic allylation of -sulfinylamines.
Shamim Fanai-Danesh, Daniel F Moseley, Kevin M Foote, Kieran D Jones, Stephen P Argent

Org Biomol Chem· November 2025

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Improvements in micelle promoted DNA-encoded library synthesis by surfactant optimisation.
Jake A Odger, Matthew J Anderson, Thomas P Carton, Bao Nguyen, Kevin Foote

Org Biomol Chem· July 2025

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Discovery of a novel series of selective macrocyclic PKCTheta inhibitors.
Stefano Crosignani, Sebastien Campos, Claire Bouix-Peter, Craig Harris, Eric Talbot, Kevin Foote

Bioorg Med Chem Lett· March 2024

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Surveillance of the Incidence and Mortality of Oral and Pharyngeal, Esophageal, and Lung Cancer in Nevada: Potential Implications of the Nevada Indoor Clean Air Act.
Kevin Foote, David Foote, Karl Kingsley

Int J Environ Res Public Health· July 2021

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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
Kevin M Foote, J Willem M Nissink, Thomas McGuire, Paul Turner, Sylvie Guichard

J Med Chem· November 2018

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.
Carl S Rye, Nicola E A Chessum, Scott Lamont, Kurt G Pike, Paul Faulder, Kevin M Foote

Medchemcomm· August 2016

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Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer.
Kevin M Foote, Alan Lau, J Willem M Nissink

Future Med Chem· April 2016

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Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.
Jason G Kettle, Husam Alwan, Michal Bista, Jason Breed, Nichola L Davies, Kevin M Foote

J Med Chem· March 2016

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An enantiospecific polyene cyclization initiated by an enantiomerically pure bromonium ion.
D Christopher Braddock, Jared S Marklew, Kevin M Foote, Andrew J P White

Chirality· November 2013

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Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
Kevin M Foote, Kevin Blades, Anna Cronin, Shaun Fillery, Sylvie S Guichard

J Med Chem· March 2013

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Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.
Richard A Norman, Anne-Kathrin Schott, David M Andrews, Jason Breed, Kevin M Foote

J Med Chem· June 2012

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Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.
Kevin M Foote, Andrew A Mortlock, Nicola M Heron, Frédéric H Jung, George B Hill

Bioorg Med Chem Lett· March 2008

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Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor.
Jean Claude Arnould, Bénédicte Delouvrié, Pascal Boutron, Al G Dossetter, Kevin M Foote

Bioorg Med Chem Lett· December 2007

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AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.
Robert W Wilkinson, Rajesh Odedra, Simon P Heaton, Stephen R Wedge, Nicholas J Keen, Kevin M Foote

Clin Cancer Res· June 2007

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Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.
Andrew A Mortlock, Kevin M Foote, Nicola M Heron, Frédéric H Jung, Georges Pasquet

J Med Chem· May 2007

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Validating Aurora B as an anti-cancer drug target.
Fiona Girdler, Karen E Gascoigne, Patrick A Eyers, Sonya Hartmuth, Claire Crafter, Kevin M Foote

J Cell Sci· September 2006

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Progress in the development of selective inhibitors of aurora kinases.
Andrew A Mortlock, Nicholas J Keen, Frederic H Jung, Nicola M Heron, Kevin M Foote

Curr Top Med Chem· October 2005

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Progress in the development of selective inhibitors of Aurora kinases.
Andrew Mortlock, Nicholas J Keen, Frederic H Jung, Nicola M Heron, Kevin M Foote

Curr Top Med Chem· June 2005

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Synthetic studies towards the phomactins. Concise syntheses of the tricyclic furanochroman and the oxygenated bicyclo[9.3.1]pentadecane ring systems in phomactin A.
Kevin M Foote, Christopher J Hayes, Matthew P John, Gerald Pattenden

Org Biomol Chem· November 2003

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Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.
Michael H Block, Scott Boyer, Wayne Brailsford, David R Brittain, Debra Carroll, Kevin M Foote

J Med Chem· August 2002

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Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats.
Andrew V Turnbull, Laraine Ellershaw, Dave J Masters, Susan Birtles, Scott Boyer, Kevin M Foote

Diabetes· August 2002

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