Publications by authors named "Kevin Stefanski"

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Enhanced aqueous dissolution of hydrophobic apixaban via direct incorporation of hydrophilic nanographene oxide.
Mohammad Saiful Islam, Faradae Renner, Kimberly Foster, Martins S Oderinde, Kevin Stefanski

Colloids Surf B Biointerfaces· August 2022

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Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
Emily C Cherney, Liping Zhang, Weiwei Guo, Audris Huang, David Williams, Kevin Stefanski

ACS Med Chem Lett· July 2021

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Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration.
Laura I Mosquera-Giraldo, Maria Donoso, Kevin Stefanski, Kimberly Foster, Christoph Gesenberg

Pharm Res· May 2021

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Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.
Qingjie Liu, Hai-Yun Xiao, Douglas G Batt, Zili Xiao, Yeheng Zhu, Kevin Stefanski

ACS Med Chem Lett· May 2021

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Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
Michael G Yang, Myra Beaudoin-Bertrand, Zili Xiao, David Marcoux, Carolyn A Weigelt, Kevin Stefanski

J Med Chem· March 2021

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Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate.
Mohammad Saiful Islam, Faradae Renner, Kimberly Foster, Martin S Oderinde, Kevin Stefanski

Molecules· March 2021

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Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.
Emily C Cherney, Liping Zhang, Susheel Nara, Xiao Zhu, Johnni Gullo-Brown, Kevin Stefanski

ACS Med Chem Lett· February 2021

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Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.
Qing Shi, Zili Xiao, Michael G Yang, David Marcoux, Robert J Cherney, Kevin Stefanski

Bioorg Med Chem Lett· December 2020

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Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.
Qingjie Liu, Douglas G Batt, Carolyn A Weigelt, Shiuhang Yip, Dauh-Rurng Wu, Kevin Stefanski

ACS Med Chem Lett· December 2020

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Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.
Robert J Cherney, Lyndon A M Cornelius, Anurag Srivastava, Carolyn A Weigelt, David Marcoux, Kevin Stefanski

ACS Med Chem Lett· June 2020

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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
David Marcoux, James J-W Duan, Qing Shi, Robert J Cherney, Anurag S Srivastava, Kevin Stefanski

J Med Chem· November 2019

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Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance.
Huijun Chen, Yipshu Pui, Chengyu Liu, Zhen Chen, Ching-Chiang Su, Kevin Stefanski

J Pharm Sci· January 2018

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Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
Qingjie Liu, Qing Shi, David Marcoux, Douglas G Batt, Lyndon Cornelius, Kevin Stefanski

J Med Chem· June 2017

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Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
Lan-Ying Qin, Zheming Ruan, Robert J Cherney, T G Murali Dhar, James Neels, Kevin Stefanski

Bioorg Med Chem Lett· February 2017

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Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction.
Yuejie Chen, Shujing Wang, Shan Wang, Chengyu Liu, Ching Su, Kevin Stefanski

Pharm Res· October 2016

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Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.
Rajeev S Bhide, James Neels, Lan-Ying Qin, Zheming Ruan, Sylwia Stachura, Kevin Stefanski

Bioorg Med Chem Lett· September 2016

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Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion.
Yuejie Chen, Shujing Wang, Shan Wang, Chengyu Liu, Ching Su, Kevin Stefanski

Mol Pharm· August 2016

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Dehydration and Stabilization of a Reactive Tertiary Hydroxyl Group in Solid Oral Dosage Forms of BMS-779788.
Monica L Adams, Vijayata Sharma, Madhushree Gokhale, Yande Huang, Kevin Stefanski

J Pharm Sci· April 2016

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Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.
Lorell N Discenza, Georgia Cornelius, Jinping Gan, Nicolas Szapiel, Randy L Talbott, Kevin Stefanski

Bioanalysis· February 2016

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Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.
Honghe Wan, Gretchen M Schroeder, Amy C Hart, Jennifer Inghrim, James Grebinski, Kevin Stefanski

ACS Med Chem Lett· August 2015

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Drug-polymer-water interaction and its implication for the dissolution performance of amorphous solid dispersions.
Yuejie Chen, Chengyu Liu, Zhen Chen, Ching Su, Michael Hageman, Kevin Stefanski

Mol Pharm· February 2015

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Oral delivery of highly lipophilic poorly water-soluble drugs: spray-dried dispersions to improve oral absorption and enable high-dose toxicology studies of a P2Y1 antagonist.
Xue-Qing Chen, Kevin Stefanski, Hong Shen, Christine Huang, Christian Caporuscio

J Pharm Sci· December 2014

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Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
Mark D Wittman, Joan M Carboni, Zheng Yang, Francis Y Lee, Melissa Antman, Kevin Stefanski

J Med Chem· December 2009

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Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.
Gretchen M Schroeder, Yongmi An, Zhen-Wei Cai, Xiao-Tao Chen, Cheryl Clark, Kevin Stefanski

J Med Chem· March 2009

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7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.
Scott D Larsen, Zhijun Zhang, Brian A DiPaolo, Peter R Manninen, Douglas C Rohrer, Kevin J Stefanski

Bioorg Med Chem Lett· July 2007

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