Publications by authors named "Lany Ruslim"

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Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain.
Danielle L Aubele, Roy K Hom, Marc Adler, Robert A Galemmo, Simeon Bowers, Lany Ruslim

ChemMedChem· August 2013

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Raymond A Ng, Minghua Sun, Simeon Bowers, Roy K Hom, Gary D Probst, Lany Ruslim

Bioorg Med Chem Lett· August 2013

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Lany Ruslim

J Med Chem· July 2013

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Simeon Bowers, Anh P Truong, Michael Ye, Danielle L Aubele, Jennifer M Sealy, Lany Ruslim

Bioorg Med Chem Lett· May 2013

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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Ying-Zi Xu, Shendong Yuan, Simeon Bowers, Roy K Hom, Wayman Chan, Lany Ruslim

Bioorg Med Chem Lett· May 2013

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Albert W Garofalo, Marc Adler, Danielle L Aubele, Elizabeth F Brigham, David Chian, Lany Ruslim

Bioorg Med Chem Lett· April 2013

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Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Simeon Bowers, Ying-zi Xu, Shendong Yuan, Gary D Probst, Roy K Hom, Lany Ruslim

Bioorg Med Chem Lett· April 2013

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Simeon Bowers, Anh P Truong, R Jeffrey Neitz, Roy K Hom, Jennifer M Sealy, Lany Ruslim

Bioorg Med Chem Lett· September 2011

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Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.
R Jeffrey Neitz, Andrei W Konradi, Hing L Sham, Wes Zmolek, Karina Wong, Lany Ruslim

Bioorg Med Chem Lett· June 2011

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Simeon Bowers, Anh P Truong, R Jeffrey Neitz, Martin Neitzel, Gary D Probst, Lany Ruslim

Bioorg Med Chem Lett· March 2011

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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Gary D Probst, Simeon Bowers, Jennifer M Sealy, Anh P Truong, Roy K Hom, Lany Ruslim

Bioorg Med Chem Lett· January 2011

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele, Lany Ruslim

Alzheimers Res Ther· December 2010

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Anh P Truong, Gergley Tóth, Gary D Probst, Jennifer M Sealy, Simeon Bowers, Lany Ruslim

Bioorg Med Chem Lett· November 2010

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Gary D Probst, Simeon Bowers, Jennifer M Sealy, Brian Stupi, Darren Dressen, Lany Ruslim

Bioorg Med Chem Lett· October 2010

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Anh P Truong, Gary D Probst, Jose Aquino, Larry Fang, Louis Brogley, Lany Ruslim

Bioorg Med Chem Lett· August 2010

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Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Jennifer M Sealy, Anh P Truong, Luke Tso, Gary D Probst, Jose Aquino, Lany Ruslim

Bioorg Med Chem Lett· November 2009

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Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
Jon E Hawkinson, Balazs G Szoke, Albert W Garofalo, Dennis S Hom, Hongbing Zhang, Lany Ruslim

J Pharmacol Exp Ther· August 2007

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A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.
James G Christensen, Randall Schreck, Jon Burrows, Poonam Kuruganti, Emily Chan, Lany Ruslim

Cancer Res· November 2003

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A widely applicable, high-throughput TR-FRET assay for the measurement of kinase autophosphorylation: VEGFR-2 as a prototype.
Deborah J Moshinsky, Lany Ruslim, Robert A Blake, Flora Tang

J Biomol Screen· August 2003

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