Publications by authors named "Leonard Favreau"

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Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.
Mihirbaran Mandal, Kaushik Mitra, Diane Grotz, Xinjie Lin, Jairam Palamanda, Leonard Favreau

J Med Chem· December 2018

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Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.
Mihirbaran Mandal, Yusheng Wu, Jeffrey Misiaszek, Guoqing Li, Alexei Buevich, Leonard Favreau

J Med Chem· April 2016

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Discovery of potent iminoheterocycle BACE1 inhibitors.
John P Caldwell, Robert D Mazzola, James Durkin, Joseph Chen, Xia Chen, Leonard Favreau

Bioorg Med Chem Lett· December 2014

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Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
Mihirbaran Mandal, Zhaoning Zhu, Jared N Cumming, Xiaoxiang Liu, Corey Strickland, Leonard Favreau

J Med Chem· November 2012

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Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction.
Andrew W Stamford, Jack D Scott, Sarah W Li, Suresh Babu, Dawit Tadesse, Leonard Favreau

ACS Med Chem Lett· November 2012

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Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Jared N Cumming, Elizabeth M Smith, Lingyan Wang, Jeffrey Misiaszek, James Durkin, Leonard Favreau

Bioorg Med Chem Lett· April 2012

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The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists.
Pauline C Ting, Joe F Lee, Margaret M Albanese, Jie Wu, Robert Aslanian, Leonard Favreau

Bioorg Med Chem Lett· September 2010

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Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Jared Cumming, Suresh Babu, Ying Huang, Carolyn Carrol, Xia Chen, Leonard Favreau

Bioorg Med Chem Lett· May 2010

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Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Johannes Voigt, Corey Strickland, Leonard Favreau

J Med Chem· February 2010

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Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
Hubert Josien, Thomas Bara, Murali Rajagopalan, John W Clader, William J Greenlee, Leonard Favreau

Bioorg Med Chem Lett· November 2009

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Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
Mark D McBriar, John W Clader, Inhou Chu, Robert A Del Vecchio, Leonard Favreau

Bioorg Med Chem Lett· January 2008

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Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.
Hubert Josien, Thomas Bara, Murali Rajagopalan, Theodros Asberom, John W Clader, Leonard Favreau

Bioorg Med Chem Lett· October 2007

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Supercritical fluid chromatography/tandem mass spectrometric method for analysis of pharmaceutical compounds in metabolic stability samples.
Yunsheng Hsieh, Leonard Favreau, John Schwerdt, K-C Cheng

J Pharm Biomed Anal· February 2006

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Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Michael Berlin, Pauline C Ting, Wayne D Vaccaro, Robert Aslanian, Kevin D McCormick, Leonard Favreau

Bioorg Med Chem Lett· February 2006

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Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Wayne D Vaccaro, Rosy Sher, Michael Berlin, Neng-Yang Shih, Robert Aslanian, Leonard Favreau

Bioorg Med Chem Lett· January 2006

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Chiral supercritical fluid chromatography/tandem mass spectrometry for the simultaneous determination of pindolol and propranolol in metabolic stability samples.
Yunsheng Hsieh, Leonard Favreau, K-C Cheng, Jiwen Chen

Rapid Commun Mass Spectrom· December 2005

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Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
Wen-Lian Wu, Duane A Burnett, Richard Spring, William J Greenlee, Michelle Smith, Leonard Favreau

J Med Chem· February 2005

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