Publications by authors named "Leonie Cluse"

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Discovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity.
Olivia Susanto, Emily Gruber, Cheng Mun Wun, Rheana L Franich, Xiao Ma, Leonie A Cluse

Mol Cancer Ther· November 2025

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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth.
Gio Fidelito, Izabela Todorovski, Leonie Cluse, Stephin J Vervoort, Renea A Taylor

Cell Rep· April 2025

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Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression.
Catarina Gago da Graça, Amania A Sheikh, Dane M Newman, Lifen Wen, Sining Li, Leonie A Cluse

Sci Immunol· January 2025

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Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML.
Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Leonie A Cluse

Cancer Discov· June 2022

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BET Inhibition Enhances TNF-Mediated Antitumor Immunity.
Lisa C Wellinger, Simon J Hogg, Dane M Newman, Thomas Friess, Daniela Geiss, Leonie A Cluse

Cancer Immunol Res· January 2022

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Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.
Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan

Mol Cell· May 2021

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CDK13 cooperates with CDK12 to control global RNA polymerase II processivity.
Zheng Fan, Jennifer R Devlin, Simon J Hogg, Maria A Doyle, Paul F Harrison, Leonie A Cluse

Sci Adv· May 2020

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A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.
Leonie A Cluse, Iva Nikolic, Deborah Knight, Piyush B Madhamshettiwar, Jennii Luu

Methods Mol Biol· January 2019

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BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.
Simon J Hogg, Stephin J Vervoort, Sumit Deswal, Christopher J Ott, Jason Li, Leonie A Cluse

Cell Rep· February 2017

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BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.
Simon J Hogg, Andrea Newbold, Stephin J Vervoort, Leonie A Cluse, Benjamin P Martin

Mol Cancer Ther· September 2016

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Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.
Geoffrey M Matthews, Parinaz Mehdipour, Leonie A Cluse, Katrina J Falkenberg, Eric Wang

Blood· November 2015

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Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities.
Andrea Newbold, Geoffrey M Matthews, Michael Bots, Leonie A Cluse, Christopher J P Clarke

Mol Cancer Ther· December 2013

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An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.
Alison C West, Stephen R Mattarollo, Jake Shortt, Leonie A Cluse, Ailsa J Christiansen

Cancer Res· December 2013

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A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
Fabio Santoro, Oronza A Botrugno, Roberto Dal Zuffo, Isabella Pallavicini, Geoffrey M Matthews, Leonie Cluse

Blood· April 2013

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Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Leonie Cluse

Cancer Cell· July 2012

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Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.
Adrian P Wiegmans, Amber E Alsop, Michael Bots, Leonie A Cluse, Steven P Williams

Cancer Res· May 2011

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Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.
Jane Oliaro, Vanessa Van Ham, Faruk Sacirbegovic, Anupama Pasam, Ze'ev Bomzon, Leonie A Cluse

J Immunol· July 2010

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The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.
Leigh Ellis, Michael Bots, Ralph K Lindemann, Jessica E Bolden, Andrea Newbold, Leonie A Cluse

Blood· July 2009

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Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.
Kate F Whitecross, Amber E Alsop, Leonie A Cluse, Adrian Wiegmans, Kellie-Marie Banks

Blood· February 2009

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Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin.
Andrea Newbold, Ralph K Lindemann, Leonie A Cluse, Kate F Whitecross, Anthony E Dear

Mol Cancer Ther· May 2008

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Mai Nguyen, Richard C Marcellus, Anne Roulston, Mark Watson, Lucile Serfass, Leonie Cluse

Proc Natl Acad Sci U S A· December 2007

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SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
Ben A Croker, Donald Metcalf, Lorraine Robb, Wei Wei, Sandra Mifsud, Leonie A Cluse

Immunity· February 2004

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Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses.
Ben A Croker, Emanuela Handman, John D Hayball, Tracey M Baldwin, Valentina Voigt, Leonie A Cluse

Immunol Cell Biol· June 2002

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The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.
Ben A Croker, David M Tarlinton, Leonie A Cluse, Alana J Tuxen, Amanda Light

J Immunol· April 2002

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