Publications by authors named "Lucas Simon"

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Caution before condemnation: rethinking responsibility for Gaza's healthcare scarcity.
Simon Lucas

J Med Ethics· December 2025

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Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool.
J Henry Blackwell, Simon C C Lucas, Giovanni Battocchio, Ulf Börjesson, Mark J Bostock

J Med Chem· December 2025

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On the Immunity of Hospitals in Gaza: A Reply to Lederman.
Simon Lucas

Bioethics· November 2025

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Modular Synthetic Platform for the Elaboration of Fragments in Three Dimensions for Fragment-Based Drug Discovery.
Andres R Gomez-Angel, Hanna F Klein, Stephen Y Yao, James R Donald, James D Firth, Simon C C Lucas

J Am Chem Soc· August 2025

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Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen.
Simon C C Lucas, Alexander G Milbradt, Jason Breed, Erwin De Genst, Anne Jackson

ACS Med Chem Lett· August 2025

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Against a Pluriversal Approach in Global Bioethics.
Simon Lucas

J Bioeth Inq· June 2025

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Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders.
Jeffrey A Boerth, Marianne Schimpl, Simon C C Lucas, Jingwen Zhang, Erin L Code

ACS Med Chem Lett· June 2025

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Discovery of a Series of Covalent Ligands That Bind to Cys77 of the Von Hippel-Lindau Tumor Suppressor Protein (VHL).
Simon C C Lucas, Yong Xu, Sarah Hewitt, Gavin W Collie, Lucia Fusani

ACS Med Chem Lett· April 2025

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Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.
Adeline Palisse, Tony Cheung, Aileen Blokhuis, Thomas Cogswell, Bruna S Martins, Simon C C Lucas

J Med Chem· December 2024

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Electrospun Poly(vinylidene fluoride) Nanocomposites with Ionic Liquid Functionalized Graphene Nanoplatelets by a Noncovalent Method for Piezoresistive Pressure Sensor Applications.
Lucas Simon, Sébastien Livi, Guilherme M O Barra, Claudia Merlini

ACS Omega· November 2024

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Hit me with your best shot: Integrated hit discovery for the next generation of drug targets.
S Neha Ashraf, J Henry Blackwell, Geoffrey A Holdgate, Simon C C Lucas, Alisa Solovyeva

Drug Discov Today· October 2024

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors.
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt

J Med Chem· September 2024

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Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1.
Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, Silvia Bonomo, Andrew Brierley

J Med Chem· July 2024

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Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays.
Thomas Gerstberger, Helmut Berger, Frank H Büttner, Michael Gmachl, Dirk Kessler, Simon Lucas

J Med Chem· July 2024

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Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen.
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt

ACS Med Chem Lett· June 2024

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Covalent hits and where to find them.
Simon C C Lucas, J Henry Blackwell, Sarah H Hewitt, Hannah Semple, Benjamin C Whitehurst

SLAS Discov· April 2024

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Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
Simon C C Lucas, Afshan Ahmed, S Neha Ashraf, Argyrides Argyrou, Matthias R Bauer

J Med Chem· April 2024

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How moral bioenhancement affects perceived praiseworthiness.
Simon Lucas, Thomas Douglas, Nadira S Faber

Bioethics· February 2024

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Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.
S Paul Jones, James D Firth, Mary C Wheldon, Masakazu Atobe, Roderick E Hubbard, Simon C C Lucas

RSC Med Chem· December 2022

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Fragment screening at AstraZeneca: developing the next generation biophysics fragment set.
Simon C C Lucas, Ulf Börjesson, Mark J Bostock, John Cuff, Fredrik Edfeldt

RSC Med Chem· September 2022

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Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
Simon C C Lucas, Stephen J Atkinson, Chun-Wa Chung, Rob Davis, Laurie Gordon, Simon Taylor

J Med Chem· August 2021

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Put a ring on it: application of small aliphatic rings in medicinal chemistry.
Matthias R Bauer, Paolo Di Fruscia, Simon C C Lucas, Iacovos N Michaelides, Jennifer E Nelson

RSC Med Chem· April 2021

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Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
Simon C C Lucas, Stephen J Atkinson, Paul Bamborough, Heather Barnett, Chun-Wa Chung

J Med Chem· May 2020

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Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions.
Alexander N Phillipou, Charles S Lay, Charlotte E Carver, Cassie Messenger, John P Evans, Simon C C Lucas

SLAS Discov· February 2020

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A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.
Paul Bamborough, Chun-Wa Chung, Emmanuel H Demont, Angela M Bridges, Peter D Craggs, Simon C C Lucas

J Med Chem· August 2019

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