Publications by authors named "Mara Dottore"

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Ultraprecision Therapy for Type 1 vs Type 2 CALR+ MPN by Dual Epitope Targeting that Restores Ruxolitinib Sensitivity.
Chloe Al Thompson-Peach, Daniel Thomas, Mara Dottore, Kelly Lim, Frank Stomski

Blood· January 2026

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Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.
Winnie L Kan, Urmi Dhagat, Kerstin B Kaufmann, Timothy R Hercus, Tracy L Nero, Mara Dottore

Cancer Discov· August 2023

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Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody.
Denis Tvorogov, Chloe A L Thompson-Peach, Johannes Foßelteder, Mara Dottore, Frank Stomski

EMBO Rep· April 2022

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Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis.
Denis Tvorogov, Daniel Thomas, Nicholas P D Liau, Mara Dottore, Emma F Barry

Sci Adv· November 2018

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A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore

Nat Commun· January 2018

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High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression.
Nicole L Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J Sandow, Melanie K Pudney, Mara Dottore

Blood Adv· June 2017

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CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors.
Con Panousis, Urmi Dhagat, Kirsten M Edwards, Veronika Rayzman, Matthew P Hardy, Mara Dottore

MAbs· December 2016

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Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Mara Dottore, Barbara J McClure

Structure· August 2016

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Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.
Sophie E Broughton, Timothy R Hercus, Matthew P Hardy, Barbara J McClure, Tracy L Nero, Mara Dottore

Cell Rep· July 2014

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High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties.
Timothy R Hercus, Emma F Barry, Mara Dottore, Barbara J McClure, Andrew I Webb

PLoS One· June 2014

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The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.
Guido Hansen, Timothy R Hercus, Barbara J McClure, Frank C Stomski, Mara Dottore

Cell· August 2008

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Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells.
Jane D Holland, Marina Kochetkova, Chareeporn Akekawatchai, Mara Dottore, Angel Lopez

Cancer Res· April 2006

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Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
Mark A Guthridge, Jason A Powell, Emma F Barry, Frank C Stomski, Barbara J McClure, Mara Dottore

EMBO J· February 2006

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