Publications by authors named "Markus Warmuth"

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Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition.
Georg Petzold, Pablo Gainza, Stefano Annunziato, Ilaria Lamberto, Peter Trenh, Markus Warmuth

Science· July 2025

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The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity.
Tuong-Vi Nguyen, Shihua Yao, Yahong Wang, Alan Rolfe, Anand Selvaraj, Markus Warmuth

J Biol Chem· November 2019

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Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Manav Korpal, Xiaoling Puyang, Zhenhua Jeremy Wu, Roland Seiler, Craig Furman, Markus Warmuth

Nat Commun· June 2019

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Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers.
Nathalie Rioux, Amy Kim, Darrell Nix, Todd Bowser, Markus Warmuth

Cancer Chemother Pharmacol· January 2019

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Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA).
Nathalie Rioux, Sherri Smith, Manav Korpal, Morgan O'Shea, Sudeep Prajapati, Markus Warmuth

Cancer Chemother Pharmacol· January 2019

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Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A Margolin, Markus Warmuth

Nature· January 2019

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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.
Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Markus Warmuth

Nat Commun· January 2019

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα and ERα Breast Cancer.
Xiaoling Puyang, Craig Furman, Guo Zhu Zheng, Zhenhua J Wu, Deepti Banka, Markus Warmuth

Cancer Discov· September 2018

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Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
Joseph Schoepfer, Wolfgang Jahnke, Giuliano Berellini, Silvia Buonamici, Simona Cotesta, Markus Warmuth

J Med Chem· September 2018

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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.
Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg Keaney, Markus Warmuth

Nat Med· May 2018

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H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Jaya Julie Joshi, Heather Coffey, Erik Corcoran, Jennifer Tsai, Chia-Ling Huang, Markus Warmuth

Cancer Res· December 2017

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Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion.
Lee A Albacker, Jeremy Wu, Peter Smith, Markus Warmuth, Philip J Stephens

PLoS One· November 2017

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Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Manav Korpal, Xiaoling Puyang, Zhenhua Jeremy Wu, Roland Seiler, Craig Furman, Markus Warmuth

Nat Commun· July 2017

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Novel in-frame deletions result in aberrant RNA splicing in CLL patients.
Anant A Agrawal, Michael Seiler, Lindsey T Brinton, Rose Mantel, Rosa Lapalombella, Markus Warmuth

Blood Adv· June 2017

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng Teng, Jennifer Hc Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Markus Warmuth

Nat Commun· May 2017

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The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Andrew A Wylie, Joseph Schoepfer, Wolfgang Jahnke, Sandra W Cowan-Jacob, Alice Loo, Markus Warmuth

Nature· March 2017

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Ying-Nan P Chen, Matthew J LaMarche, Ho Man Chan, Peter Fekkes, Jorge Garcia-Fortanet, Markus Warmuth

Nature· July 2016

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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms.
Manav Korpal, Jacob Feala, Xiaoling Puyang, Jian Zou, Alex H Ramos, Markus Warmuth

J Vis Exp· December 2015

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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.
Rachel B Darman, Michael Seiler, Anant A Agrawal, Kian H Lim, Shouyong Peng, Markus Warmuth

Cell Rep· November 2015

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Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.
Kenzo Arai, Silvia Buonamici, Betty Chan, Laura Corson, Atsushi Endo, Markus Warmuth

Org Lett· November 2014

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NAMPT is the cellular target of STF-31-like small-molecule probes.
Drew J Adams, Daisuke Ito, Matthew G Rees, Brinton Seashore-Ludlow, Xiaoling Puyang, Markus Warmuth

ACS Chem Biol· October 2014

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Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
Thomas H Marsilje, Wei Pei, Bei Chen, Wenshuo Lu, Tetsuo Uno, Markus Warmuth

J Med Chem· July 2013

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A Margolin, Markus Warmuth

Nature· March 2012

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Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.
Sarah Decker, Katja Zirlik, Lauritte Djebatchie, David Hartmann, Gabriele Ihorst, Markus Warmuth

Blood· January 2012

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Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.
Alix Scholer-Dahirel, Michael R Schlabach, Alice Loo, Linda Bagdasarian, Ronald Meyer, Markus Warmuth

Proc Natl Acad Sci U S A· October 2011

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