Publications by authors named "Martin Clynes"

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Detection of host cell microprotein impurities in antibody drug products.
Ioanna Tzani, Marina Castro-Rivadeneyra, Paul Kelly, Lisa Strasser, Lin Zhang, Martin Clynes

Nat Commun· October 2024

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Serum-Free and Protein-Free Media for the Cultivation of Recombinant Chinese Hamster Ovary (CHO) Cell Lines.
Berta Capella Roca, Justine Meiller, Padraig Doolan, Martin Clynes

Methods Mol Biol· October 2024

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Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors.
Alan Costello, Nga Lao, Martin Clynes, Niall Barron

Methods Mol Biol· October 2024

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miRNA- and Cell Line-Specific Constraints on Precursor miRNA Processing of Stably Transfected Pancreatic Cancer and Other Mammalian Cells.
Taylor J Allen-Coyle, Berta Capella Roca, Alan Costello, Niall Barron, Joanne Keenan, Martin Clynes

Int J Mol Sci· May 2024

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Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors.
Tista Roy Chaudhuri, Qingxiang Lin, Ewa K Stachowiak, Spencer R Rosario, Joseph A Spernyak, Martin Clynes

Clin Cancer Res· April 2024

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Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.
Martina S J McDermott, Brigid C Browne, Neil T Conlon, Neil A O'Brien, Dennis J Slamon, Martin Clynes

Mol Cancer· October 2023

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Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors.
Fiona O'Neill, Taylor-Jade Allen-Coyle, Sandra Roche, Justine Meiller, Neil T Conlon, Martin Clynes

Life (Basel)· February 2023

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Yeast Mannan-Rich Fraction Modulates Endogenous Reactive Oxygen Species Generation and Antibiotic Sensitivity in Resistant .
Helen Smith, Sharon Grant, Paula Meleady, Michael Henry, Donal O'Gorman, Martin Clynes

Int J Mol Sci· December 2022

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FOLFIRINOX Pharmacodynamic Interactions in 2D and 3D Pancreatic Cancer Cell Cultures.
Taylor J Allen-Coyle, Jin Niu, Eva Welsch, Neil T Conlon, Weylon Garner, Martin Clynes

AAPS J· October 2022

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Label-Free Quantitative Proteomics Analysis of Adriamycin Selected Multidrug Resistant Human Lung Cancer Cells.
Esen Efeoglu, Michael Henry, Martin Clynes, Paula Meleady

Biomolecules· October 2022

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Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion protein.
Laura Bryan, Michael Henry, Niall Barron, Clair Gallagher, Ronan M Kelly, Martin Clynes

Biotechnol Lett· August 2021

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Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential proteomic analysis.
Laura Bryan, Michael Henry, Ronan M Kelly, Christopher C Frye, Matthew D Osborne, Martin Clynes

BMC Biotechnol· July 2021

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The emerging role of cellular post-translational modifications in modulating growth and productivity of recombinant Chinese hamster ovary cells.
Laura Bryan, Martin Clynes, Paula Meleady

Biotechnol Adv· June 2021

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Transfection of miR-31* boosts oxidative phosphorylation metabolism in the mitochondria and enhances recombinant protein production in Chinese hamster ovary cells.
Jesus E Martinez-Lopez, Orla Coleman, Paula Meleady, Martin Clynes

J Biotechnol· June 2021

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Copper toxicity of inflection point in human intestinal cell line Caco-2 dissected: influence of temporal expression patterns.
Joanne Keenan, Paula Meleady, Charles O'Doherty, Michael Henry, Martin Clynes

In Vitro Cell Dev Biol Anim· March 2021

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Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition.
Nicoló Zuin Fantoni, Zara Molphy, Sinéad O'Carroll, Georgia Menounou, George Mitrikas, Martin Clynes

Chemistry· January 2021

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Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify to Be Involved in Invasion and Progression of Pancreatic Cancer.
Shannon R Nelson, Sandra Roche, Maura Cotter, Pablo Anton Garcia, Daniela Reitmeier, Martin Clynes

J Oncol· December 2020

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Development of whole-cell and cell-free biosensors for the detection and differentiation of organic and inorganic forms of copper.
Alan Costello, Joanne Parker, Martin Clynes, Richard Murphy

Metallomics· November 2020

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Gene expression profiling of copper-resistant Caco-2 clones.
Charles O'Doherty, Joanne Keenan, Fiona O'Neill, Martin Clynes, Indre Sinkunaite

Metallomics· October 2020

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Proteomic Analysis of Cell Lines and Primary Tumors in Pancreatic Cancer Identifies Proteins Expressed Only In Vitro and Only In Vivo.
Orla Coleman, Michael Henry, Fiona O'Neill, Sandra Roche, Niall Swan, Martin Clynes

Pancreas· September 2020

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Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells.
Ioanna Tzani, Craig Monger, Krishna Motheramgari, Clair Gallagher, Ryan Hagan, Martin Clynes

Biotechnol Bioeng· August 2020

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DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models.
Michael C Johnston, Julie A Nicoll, Kelly M Redmond, Peter Smyth, Michelle K Greene, Martin Clynes

J Control Release· August 2020

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Altered gene expression in CHO cells following polyamine starvation.
Berta Capella Roca, Padraig Doolan, Niall Barron, Fiona O'Neill, Martin Clynes

Biotechnol Lett· June 2020

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Proteomic analysis of pancreatic ductal adenocarcinoma.
Paula Meleady, Rozana Abdul Rahman, Michael Henry, Michael Moriarty, Martin Clynes

Expert Rev Proteomics· June 2020

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LC-MS proteomic profiling of Caco-2 human intestinal cells exposed to the copper-chelating agent, triethylenetetramine: A preliminary study.
Charles O'Doherty, Finbarr O'Sullivan, Michael Henry, Paula Meleady, Martin Clynes

Biochem Biophys Res Commun· April 2020

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