Publications by authors named "Matthew A Seager"

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Evaluation of 5-HT receptor antagonism for the treatment of anxiety, depression, and schizophrenia through the use of receptor-deficient mice.
Olivia M Balcer, Matthew A Seager, Scott D Gleason, Xia Li, Kurt Rasmussen

Behav Brain Res· March 2019

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MK-7622: A First-in-Class M Positive Allosteric Modulator Development Candidate.
Douglas C Beshore, Christina N Di Marco, Ronald K Chang, Thomas J Greshock, Lei Ma, Matthew A Seager

ACS Med Chem Lett· July 2018

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Triazolopyridine ethers as potent, orally active mGlu positive allosteric modulators for treating schizophrenia.
Mendi A Higgins, Lawrence R Marcin, F Christopher Zusi, Robert Gentles, Min Ding, Matthew A Seager

Bioorg Med Chem· January 2017

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Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy.
Yu-Wen Li, Matthew A Seager, Trevor Wojcik, Karen Heman, Thaddeus F Molski

Neuropharmacology· March 2016

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Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.
Zhi-Qiang Yang, Youheng Shu, Lei Ma, Marion Wittmann, William J Ray, Matthew A Seager

ACS Med Chem Lett· May 2014

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Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.
Scott D Kuduk, Ronald K Chang, Thomas J Greshock, William J Ray, Lei Ma, Matthew A Seager

ACS Med Chem Lett· December 2012

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Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
Scott D Kuduk, Ronald K Chang, Christina N Di Marco, Daniel R Pitts, Thomas J Greshock, Matthew A Seager

J Med Chem· July 2011

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Fused heterocyclic M1 positive allosteric modulators.
Scott D Kuduk, Christina N Di Marco, Victoria Cofre, William J Ray, Lei Ma, Matthew A Seager

Bioorg Med Chem Lett· May 2011

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Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.
Scott D Kuduk, Ronald K Chang, Christina N Di Marco, William J Ray, Lei Ma, Matthew A Seager

Bioorg Med Chem Lett· March 2011

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Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators.
Scott D Kuduk, Ronald K Chang, Christina N Di Marco, William J Ray, Lei Ma, Matthew A Seager

ACS Med Chem Lett· September 2010

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Heterocyclic fused pyridone carboxylic acid M(1) positive allosteric modulators.
Scott D Kuduk, Christina N Di Marco, Ronald K Chang, William J Ray, Lei Ma, Matthew A Seager

Bioorg Med Chem Lett· April 2010

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Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators.
Scott D Kuduk, Robert M DiPardo, Douglas C Beshore, William J Ray, Lei Ma, Matthew A Seager

Bioorg Med Chem Lett· April 2010

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Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.
Wei-Qin Zhao, Francesca Santini, Robert Breese, Dave Ross, Xiaohua Douglas Zhang, Matthew A Seager

J Biol Chem· March 2010

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N-heterocyclic derived M1 positive allosteric modulators.
Scott D Kuduk, Christina N Di Marco, Victoria Cofre, Daniel R Pitts, William J Ray, Matthew A Seager

Bioorg Med Chem Lett· February 2010

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Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.
Scott D Kuduk, Christina N Di Marco, Victoria Cofre, Daniel R Pitts, William J Ray, Matthew A Seager

Bioorg Med Chem Lett· January 2010

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.
Feng V Yang, William D Shipe, Jaime L Bunda, M Brad Nolt, David D Wisnoski, Matthew A Seager

Bioorg Med Chem Lett· January 2010

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Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
Lei Ma, Matthew A Seager, Marion Wittmann, Marlene Jacobson, Denise Bickel

Proc Natl Acad Sci U S A· September 2009

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Nonpharmacological amelioration of age-related learning deficits: the impact of hippocampal theta-triggered training.
Yukiko Asaka, Kristin N Mauldin, Amy L Griffin, Matthew A Seager, Elizabeth Shurell

Proc Natl Acad Sci U S A· September 2005

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Chronic coadministration of olanzapine and fluoxetine activates locus coeruleus neurons in rats: implications for bipolar disorder.
Matthew A Seager, Vanessa N Barth, Lee A Phebus, Kurt Rasmussen

Psychopharmacology (Berl)· August 2005

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The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats.
Kurt Rasmussen, Heidi Martin, James E Berger, Matthew A Seager

Neuropharmacology· February 2005

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Differential mastication kinematics of the rabbit in response to food and water: implications for conditioned movement.
Keith D Huff, Yukiko Asaka, Amy L Griffin, William P Berg, Matthew A Seager

Integr Physiol Behav Sci· January 2005

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Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity.
Matthew A Seager, Keith D Huff, Vanessa N Barth, Lee A Phebus, Kurt Rasmussen

Biol Psychiatry· June 2004

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Conditioning-specific reflex modification of the rabbit (Oryctolagus cuniculus) nictitating membrane response: US intensity effects.
Matthew A Seager, Carrie A Smith-Bell, Bernard G Schreurs

Learn Behav· August 2003

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Oscillatory brain states and learning: Impact of hippocampal theta-contingent training.
Matthew A Seager, Lynn D Johnson, Elizabeth S Chabot, Yukiko Asaka, Stephen D Berry

Proc Natl Acad Sci U S A· February 2002

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