Publications by authors named "Michael A Statnick"

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The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
Chris Cook, Nicolas Nunn, Amy A Worth, David A Bechtold, Todd Suter, Michael A Statnick

PLoS One· October 2022

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The current state of GPCR-based drug discovery to treat metabolic disease.
Kyle W Sloop, Paul J Emmerson, Michael A Statnick, Francis S Willard

Br J Pharmacol· November 2018

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Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5.
Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Michael A Statnick

Endocrinology· November 2017

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Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction.
Marsida Kallupi, Giulia Scuppa, Giordano de Guglielmo, Girolamo Calò, Friedbert Weiss, Michael A Statnick

Neuropsychopharmacology· February 2017

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Consequences of constitutive deletion of melanin-concentrating hormone-1 receptors for feeding and foraging behaviors of mice.
William J A Eiler, Yanyun Chen, Lawrence J Slieker, Paul A Ardayfio, Michael A Statnick

Behav Brain Res· January 2017

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An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.
Kjell A Svensson, Beverly A Heinz, John M Schaus, James P Beck, Junliang Hao, Michael A Statnick

J Pharmacol Exp Ther· January 2017

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Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.
Jeffrey M Witkin, Linda M Rorick-Kehn, Mark J Benvenga, Benjamin L Adams, Scott D Gleason, Michael A Statnick

Pharmacol Res Perspect· December 2016

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Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects.
Eyas Raddad, Amy Chappell, Jeffery Meyer, Alan Wilson, Charles E Ruegg, Michael A Statnick

Drug Metab Dispos· September 2016

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A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models.
Linda M Rorick-Kehn, Roberto Ciccocioppo, Conrad J Wong, Jeffrey M Witkin, Maria A Martinez-Grau, Michael A Statnick

Alcohol Clin Exp Res· May 2016

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A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder.
Michael A Statnick, Yanyun Chen, Michael Ansonoff, Jeffrey M Witkin, Linda Rorick-Kehn

J Pharmacol Exp Ther· February 2016

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The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.
Garron T Dodd, Amy A Worth, Nicolas Nunn, Aaron K Korpal, David A Bechtold, Michael A Statnick

Cell Metab· October 2014

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Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Linda M Rorick-Kehn, Jennifer W Witcher, Stephen L Lowe, Celedon R Gonzales, Mary Ann Weller, Michael A Statnick

Int J Neuropsychopharmacol· October 2014

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Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.
Miguel A Toledo, Concepción Pedregal, Celia Lafuente, Nuria Diaz, Maria Angeles Martinez-Grau, Michael A Statnick

J Med Chem· April 2014

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The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.
Jeffrey M Witkin, Michael A Statnick, Linda M Rorick-Kehn, John E Pintar, Michael Ansonoff

Pharmacol Ther· March 2014

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LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders.
Linda M Rorick-Kehn, Jeffrey M Witkin, Michael A Statnick, Elizabeth L Eberle, Jamie H McKinzie

Neuropharmacology· February 2014

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Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis.
Traci A Czyzyk, Jessica L Andrews, Tamer Coskun, Mark R Wade, Eric D Hawkins, Michael A Statnick

Am J Physiol Endocrinol Metab· July 2013

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Mice lacking δ-opioid receptors resist the development of diet-induced obesity.
Traci A Czyzyk, Amparo Romero-Picó, John Pintar, Jaime H McKinzie, Matthias H Tschöp, Michael A Statnick

FASEB J· August 2012

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Development of LC-MS/MS-based receptor occupancy tracers and positron emission tomography radioligands for the nociceptin/orphanin FQ (NOP) receptor.
Concepción Pedregal, Elizabeth M Joshi, Miguel A Toledo, Celia Lafuente, Nuria Diaz, Michael A Statnick

J Med Chem· June 2012

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Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer.
Charles H Mitch, Steven J Quimby, Nuria Diaz, Concepcion Pedregal, Marta G de la Torre, Michael A Statnick

J Med Chem· December 2011

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CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice.
Sarah Haas Lockie, Traci A Czyzyk, Nilika Chaudhary, Diego Perez-Tilve, Stephen C Woods, Michael A Statnick

Endocrinology· October 2011

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Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus.
Melissa J Chee, Christopher J Price, Michael A Statnick, William F Colmers

J Physiol· July 2011

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Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomography.
Victor W Pike, Karen S Rash, Zhaogen Chen, Concepción Pedregal, Michael A Statnick

J Med Chem· April 2011

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Pharmacological characterization of the cannabinoid CB₁ receptor PET ligand ortholog, [³H]MePPEP.
Todd M Suter, Amy K Chesterfield, Chun Bao, John M Schaus, Joseph H Krushinski, Michael A Statnick

Eur J Pharmacol· December 2010

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A model of binge-like eating behavior in mice that does not require food deprivation or stress.
Traci A Czyzyk, Allison E Sahr, Michael A Statnick

Obesity (Silver Spring)· September 2010

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kappa-Opioid receptors control the metabolic response to a high-energy diet in mice.
Traci A Czyzyk, Ruben Nogueiras, John F Lockwood, Jamie H McKinzie, Tamer Coskun, Michael A Statnick

FASEB J· April 2010

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