Publications by authors named "Michael Hack"

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Persistence of anti-platelet factor 4 antibodies in vaccine-induced immune thrombocytopenia and thrombosis for 3 years.
Michael Hack, Donald M Arnold, Rumi Clare, Yi Zhang, Nikola Ivetic

J Thromb Haemost· December 2025

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Input Pose is Key to Performance of Free Energy Perturbation: Benchmarking with Monoacylglycerol Lipase.
Donya Ohadi, Kiran Kumar, Suchitra Ravula, Renee L DesJarlais, Mark J Seierstad, Michael D Hack

J Chem Inf Model· December 2024

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Hematology in the post-COVID era: spotlight on vaccine-induced immune thrombotic thrombocytopenia and a conceptual framework (the 4P's) for anti-PF4 diseases.
Nadia Gabarin, Michael Hack, Ryan Revilla, Donald M Arnold, Ishac Nazy

Expert Rev Hematol· February 2024

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Vaccine-Induced Immune Thrombotic Thrombocytopenia: Clinicopathologic Features and New Perspectives on Anti-PF4 Antibody-Mediated Disorders.
Yi Zhang, Anna-Lise Bissola, Jared Treverton, Michael Hack, Mark Lychacz

J Clin Med· February 2024

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Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human.
Kevin J Coe, Mark Feinstein, J William Higgins, Perry Leung, Brian P Scott, Michael Hack

Drug Metab Dispos· August 2022

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Impact of Protein Preparation on Resulting Accuracy of FEP Calculations.
Amy Y Shih, Michael Hack, Taraneh Mirzadegan

J Chem Inf Model· November 2020

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An Analysis of Different Components of a High-Throughput Screening Library.
Arjun Saha, Teena Varghese, Annie Liu, Samantha J Allen, Taraneh Mirzadegan, Michael D Hack

J Chem Inf Model· October 2018

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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
Jonathan M Blevitt, Michael D Hack, Krystal L Herman, Paul F Jackson, Paul J Krawczuk

J Med Chem· April 2017

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A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.
Jonathan M Blevitt, Michael D Hack, Krystal Herman, Leon Chang, John M Keith

J Biol Chem· June 2016

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The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands.
Brad M Savall, Steven P Meduna, Jennifer Venable, Jianmei Wei, Russell C Smith, Michael D Hack

Bioorg Med Chem Lett· December 2014

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Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
Brad M Savall, Frank Chavez, Kevin Tays, Paul J Dunford, Jeffery M Cowden, Michael D Hack

J Med Chem· March 2014

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Library enhancement through the wisdom of crowds.
Michael D Hack, Dmitrii N Rassokhin, Christophe Buyck, Mark Seierstad, Andrew Skalkin

J Chem Inf Model· December 2011

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Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists.
Da-Thao Tran, Pascal Bonaventure, Michael Hack, Taraneh Mirzadegan, Curt Dvorak

Eur J Pharmacol· September 2011

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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Natalie A Hawryluk, Jeffrey E Merit, Alec D Lebsack, Bryan J Branstetter, Michael D Hack

Bioorg Med Chem Lett· December 2010

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Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands.
Brad M Savall, James P Edwards, Jennifer D Venable, Daniel J Buzard, Robin Thurmond, Michael Hack

Bioorg Med Chem Lett· June 2010

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Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.
Mark D Rosen, Craig R Woods, Steven D Goldberg, Michael D Hack, A Dawn Bounds

Bioorg Med Chem Lett· December 2009

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Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.
Alec D Lebsack, Bryan J Branstetter, Michael D Hack, Wei Xiao, Matthew L Peterson

Bioorg Med Chem Lett· January 2009

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A systemic combination therapy with granulocyte-colony stimulating factor plus erythropoietin aggravates the healing process of balloon-injured rat carotid arteries.
Michael Hack, Frank G Mascha, Bertram J Jobst, Guenter A J Riegger, Daniel P Griese

Cardiovasc Drugs Ther· October 2008

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Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.
Mark D Rosen, Michael D Hack, Brett D Allison, Victor K Phuong, Craig R Woods

Bioorg Med Chem· April 2008

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SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists.
Laurent Gomez, Michael D Hack, Kelly McClure, Clark Sehon, Liming Huang

Bioorg Med Chem Lett· December 2007

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2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2.
Danielle K Neff, Alice Lee-Dutra, Jonathan M Blevitt, Frank U Axe, Michael D Hack

Bioorg Med Chem Lett· December 2007

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Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands.
Craig R Woods, Michael D Hack, Brett D Allison, Victor K Phuong, Mark D Rosen

Bioorg Med Chem Lett· December 2007

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R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.
Chester Kuei, Steven Sutton, Pascal Bonaventure, Cindy Pudiak, Jonathan Shelton, Michael D Hack

J Biol Chem· August 2007

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Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis.
Laurent Gomez, Michael D Hack, Jiejun Wu, John J M Wiener, Hari Venkatesan

Bioorg Med Chem Lett· May 2007

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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains.
John J M Wiener, Laurent Gomez, Hariharan Venkatesan, Alejandro Santillán, Brett D Allison, Michael D Hack

Bioorg Med Chem Lett· May 2007

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