Publications by authors named "Michael Patane"

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Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPARδ modulators.
Bharat Lagu, Ramesh S Senaiar, Arthur F Kluge, B Mallesh, M Ramakrishna, Michael A Patane

Bioorg Med Chem Lett· February 2020

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Correction to "Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)".
Bharat Lagu, Arthur F Kluge, Effie Tozzo, Ross Fredenburg, Eric L Bell, Michael A Patane

ACS Med Chem Lett· June 2019

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Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD).
Bharat Lagu, Arthur F Kluge, Effie Tozzo, Ross Fredenburg, Eric L Bell, Michael A Patane

ACS Med Chem Lett· September 2018

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Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Loren M Lasko, Clarissa G Jakob, Rohinton P Edalji, Wei Qiu, Debra Montgomery, Michael A Patane

Nature· June 2018

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Corrigendum to "1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents" [Bioorg. Med. Chem. Lett. 27 (2017) 4471-4477].
Alan B Cooper, Stephane Ciblat, Gerald Shipps, Jedd Levine, Matthew Kostura, Michael Patane

Bioorg Med Chem Lett· March 2018

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Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.
Bharat Lagu, Arthur F Kluge, Matthew M Goddeeris, Effie Tozzo, Ross A Fredenburg, Michael A Patane

Bioorg Med Chem Lett· February 2018

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Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.
Michael R Michaelides, Arthur Kluge, Michael Patane, John H Van Drie, Ce Wang

ACS Med Chem Lett· January 2018

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Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing.
Bharat Lagu, Arthur F Kluge, Ross A Fredenburg, Effie Tozzo, Ramesh S Senaiar, Michael A Patane

Bioorg Med Chem Lett· December 2017

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1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents.
Alan B Cooper, Stephane Ciblat, Gerald Shipps, Jedd Levine, Matthew Kostura, Michael Patane

Bioorg Med Chem Lett· September 2017

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Antibacterial and Solubility Optimization of Thiomuracin A.
Matthew J LaMarche, Jennifer A Leeds, Jason Brewer, Karl Dean, Jian Ding, Michael A Patane

J Med Chem· July 2016

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Initial report of near-infrared fluorescence imaging as an intraoperative adjunct for lymph node harvesting during robot-assisted laparoscopic gastrectomy.
Gabriel Herrera-Almario, Michael Patane, Inderpal Sarkaria, Vivian E Strong

J Surg Oncol· June 2016

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Evaluation of ocular and general safety following repeated dosing of dexamethasone phosphate delivered by transscleral iontophoresis in rabbits.
Michael A Patane, William Schubert, Thomas Sanford, Raymond Gee, Melissa Burgos

J Ocul Pharmacol Ther· October 2013

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Antibiotic optimization and chemical structure stabilization of thiomuracin A.
Matthew J LaMarche, Jennifer A Leeds, Joanne Dzink-Fox, Eric Gangl, Philipp Krastel, Michael A Patane

J Med Chem· August 2012

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Discovery of LFF571: an investigational agent for Clostridium difficile infection.
Matthew J LaMarche, Jennifer A Leeds, Adam Amaral, Jason T Brewer, Simon M Bushell, Michael A Patane

J Med Chem· March 2012

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Evaluation of dexamethasone phosphate delivered by ocular iontophoresis for treating noninfectious anterior uveitis.
Amy E Cohen, Carol Assang, Michael A Patane, Stephen From, Michael Korenfeld

Ophthalmology· January 2012

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Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
Matthew J LaMarche, Jennifer A Leeds, Kerri Amaral, Jason T Brewer, Simon M Bushell, Michael A Patane

J Med Chem· December 2011

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4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs.
Matthew J LaMarche, Jennifer A Leeds, JoAnne Dzink-Fox, Steve Mullin, Michael A Patane

Bioorg Med Chem Lett· June 2011

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Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial.
Michael A Patane, Amy Cohen, Stephen From, Gail Torkildsen, Donna Welch

Clin Ophthalmol· June 2011

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4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding.
Matthew J LaMarche, Jennifer A Leeds, JoAnne Dzink-Fox, Karl Gunderson, Philipp Krastel, Michael A Patane

J Med Chem· April 2011

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Trans-scleral iontophoretic delivery of low molecular weight therapeutics.
Sevgi Güngör, M Begoña Delgado-Charro, Begoña Ruiz-Perez, William Schubert, Phil Isom, Michael A Patane

J Control Release· October 2010

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Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
Shomir Ghosh, Amy Elder, Jianping Guo, Ukti Mani, Michael Patane

J Med Chem· May 2006

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Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists.
Tricia J Vos, Suresh Balani, Christopher Blackburn, Ryan W Chau, M Diana Danca, Michael A Patane

Bioorg Med Chem Lett· April 2006

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Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.
Anil Vasudevan, Matthew J LaMarche, Christopher Blackburn, Jennifer Lee Che, Courtney A Luchaco-Cullis, Michael A Patane

Bioorg Med Chem Lett· October 2005

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Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists.
Philip R Kym, Rajesh Iyengar, Andrew J Souers, John K Lynch, Andrew S Judd, Michael Patane

J Med Chem· September 2005

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Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R).
Thomas H Marsilje, Jonathan B Roses, Emily F Calderwood, Stephen G Stroud, Nancy E Forsyth, Michael A Patane

Bioorg Med Chem Lett· July 2004

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