Publications by authors named "Patrick Trapa"

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Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy.
Branka Grubor, Kate L Henry, Su Jing Chan, Mark Sheehan, Anumeha Shah, Patrick Trapa

Mol Ther Methods Clin Dev· December 2025

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Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice.
Zachary C E Hawley, Ingrid D Pardo, Shaolong Cao, Maria I Zavodszky, Fergal Casey, Patrick Trapa

Mol Ther· January 2025

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Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler, Patrick Trapa

J Med Chem· June 2024

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The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)--(6-methylpyrazolo[1,5-]pyrimidin-3-yl)imidazo[1,2-]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
Ryan Evans, Philippe N Bolduc, Magnus Pfaffenbach, Fang Gao, Tricia May-Dracka, Patrick Trapa

J Med Chem· March 2024

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Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit.
Eric Tien, Branka Grubor, Melissa Kirkland, Su Jing Chan, Nick van der Munnik, Patrick Trapa

Toxicol Pathol· January 2024

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Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective.
Cheng Fang, Ye Wang, Richard Grater, Sudarshan Kapadnis, Cheryl Black, Patrick Trapa

J Chem Inf Model· June 2023

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Target occupancy study and whole-body dosimetry with a MAGL PET ligand [C]PF-06809247 in non-human primates.
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Patrick Trapa

EJNMMI Res· March 2022

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Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors.
Pete Clarner, Shukkwan K Lau, Twinkle Chowdhury, Edward Guilmette, Patrick Trapa

Mol Ther Methods Clin Dev· December 2021

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Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Eris Bame, Hao Tang, Jeremy C Burns, Million Arefayene, Klaus Michelsen, Patrick Trapa

Clin Transl Immunology· June 2021

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Optimization of dose and route of administration of the P-glycoprotein inhibitor, valspodar (PSC-833) and the P-glycoprotein and breast cancer resistance protein dual-inhibitor, elacridar (GF120918) as dual infusion in rats.
Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, Richard Grater, Daniel Qiu, Patrick Trapa

Pharmacol Res Perspect· April 2021

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Harnessing Preclinical Data as a Predictive Tool for Human Brain Tissue Targeting.
Nandini C Patel, Bo Feng, Xinjun Hou, Mark A West, Patrick E Trapa

ACS Chem Neurosci· March 2021

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D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects.
Damon Young, Michael Popiolek, Patrick Trapa, Kari R Fonseca, Julie Brevard

ACS Chem Neurosci· February 2020

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Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity.
Lei Zhang, Christopher R Butler, Kevin P Maresca, Akihiro Takano, Sangram Nag, Patrick Trapa

J Med Chem· September 2019

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In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.
Patrick E Trapa, Matthew D Troutman, Thomas Y Lau, Travis T Wager, Tristan S Maurer

Drug Metab Dispos· April 2019

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Insights from mathematical modeling for convection-enhanced intraputamenal delivery of GDNF.
Elena Belova, Christopher L Shaffer, Patrick E Trapa

Med Biol Eng Comput· December 2017

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Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.
Harvey Wong, Tonika Bohnert, Valeriu Damian-Iordache, Christopher Gibson, Cheng-Pang Hsu, Patrick Trapa

Drug Discov Today· October 2017

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Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
Antonia F Stepan, Michelle M Claffey, Matthew R Reese, Gayatri Balan, Gabriela Barreiro, Patrick Trapa

J Med Chem· September 2017

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In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.
Patrick E Trapa, Kevin Beaumont, Karen Atkinson, Heather Eng, Amanda King-Ahmad

J Pharm Sci· March 2017

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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Steven H Liang, Jinshan Michael Chen, Marc D Normandin, Jeanne S Chang, George C Chang, Patrick Trapa

Angew Chem Int Ed Engl· August 2016

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Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration.
Patrick E Trapa, Elena Belova, Jenny L Liras, Dennis O Scott, Stefan J Steyn

J Pharm Sci· February 2016

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Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape.
Edgar Schuck, Tonika Bohnert, Arijit Chakravarty, Valeriu Damian-Iordache, Christopher Gibson, Patrick Trapa

AAPS J· March 2015

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Enhancing ketamine translational pharmacology via receptor occupancy normalization.
Christopher L Shaffer, Sarah M Osgood, Deborah L Smith, JianHua Liu, Patrick E Trapa

Neuropharmacology· November 2014

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Permeability comparison between hepatocyte and low efflux MDCKII cell monolayer.
Rui Li, Yi-An Bi, Yurong Lai, Kiyohiko Sugano, Stefanus J Steyn, Patrick E Trapa

AAPS J· July 2014

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Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
Lei Zhang, Gayatri Balan, Gabriela Barreiro, Brian P Boscoe, Lois K Chenard, Patrick Trapa

J Med Chem· February 2014

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