Publications by authors named "Richard Butt"

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Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours.
Héléne T Cronjé, Sile Hu, Rachel Gurrell, Marijana Vujkovic, Susanna C Larsson, Richard Butt

medRxiv· November 2025

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Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors.
Paul A Glossop, Paul Brear, Susanne Wright, Neil Flanagan, Melanie S Glossop, Richard P Butt

J Med Chem· October 2025

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Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Na 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects.
Pieter Siebenga, Guido van Amerongen, Justin L Hay, Aoibhinn McDonnell, Donal Gorman, Richard Butt

Clin Transl Sci· March 2020

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Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA partial agonist, in humans.
Guido van Amerongen, Pieter S Siebenga, Rachel Gurrell, Pinky Dua, Mark Whitlock, Richard P Butt

Br J Anaesth· August 2019

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Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs.
Pieter S Siebenga, Guido van Amerongen, Pieter Okkerse, William S Denney, Pinky Dua, Richard P Butt

Eur J Pain· July 2019

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Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator.
Rachel Gurrell, Donal Gorman, Mark Whitlock, Adam Ogden, David S Reynolds, Richard P Butt

Neurology· April 2019

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A randomised, placebo-controlled clinical trial with the α2/3/5 subunit selective GABAA positive allosteric modulator PF-06372865 in patients with chronic low back pain.
Rachel Gurrell, Pinky Dua, Gang Feng, Maria Sudworth, Mark Whitlock, Richard P Butt

Pain· September 2018

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Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy.
Aoibhinn McDonnell, Susie Collins, Zahid Ali, Laura Iavarone, Raulin Surujbally, Richard P Butt

Pain· August 2018

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Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.
Peter Loudon, Pieter Siebenga, Donal Gorman, Katrina Gore, Pinky Dua, Richard P Butt

Br J Clin Pharmacol· February 2018

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Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA receptor positive allosteric modulator PF-06372865.
Sarah A Nickolls, Rachel Gurrell, Guido van Amerongen, Juha Kammonen, Lishuang Cao, Richard P Butt

Br J Pharmacol· February 2018

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na1.7.
Nigel A Swain, Dave Batchelor, Serge Beaudoin, Bruce M Bechle, Paul A Bradley, Richard P Butt

J Med Chem· August 2017

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The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.
Pieter Okkerse, Guido van Amerongen, Marieke L de Kam, Jasper Stevens, Richard P Butt

Br J Clin Pharmacol· May 2017

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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Richard P Butt

PLoS One· August 2016

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Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.
Hannah M Jones, Richard P Butt, Rob W Webster, Ian Gurrell, Pawel Dzygiel

Clin Pharmacokinet· July 2016

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Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.
Lishuang Cao, Aoibhinn McDonnell, Anja Nitzsche, Aristos Alexandrou, Pierre-Philippe Saintot, Richard Butt

Sci Transl Med· April 2016

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Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis.
Shannon D Shields, Richard P Butt, Sulayman D Dib-Hajj, Stephen G Waxman

PLoS One· January 2016

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A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability.
Claire Elizabeth Payne, Adam R Brown, Jonathon W Theile, Alexandre J C Loucif, Aristos J Alexandrou, Richard P Butt

Br J Pharmacol· May 2015

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Ken McCormack, Sonia Santos, Mark L Chapman, Douglas S Krafte, Brian E Marron, Richard P Butt

Proc Natl Acad Sci U S A· July 2013

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Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.
Neil Benson, Nelleke Snelder, Bart Ploeger, Carolyn Napier, Harriet Sale, Richard P Butt

Br J Pharmacol· May 2010

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Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
Paul V Fish, Gillian A Allan, Simon Bailey, Julian Blagg, Richard Butt

J Med Chem· July 2007

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Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.
Paul V Fish, Christopher G Barber, David G Brown, Richard Butt, Michael G Collis

J Med Chem· May 2007

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Inhibition of procollagen C-proteinase reduces scar hypertrophy in a rabbit model of cutaneous scarring.
Russell R Reid, Jon E Mogford, Richard Butt, Alex deGiorgio-Miller, Thomas A Mustoe

Wound Repair Regen· October 2006

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A comparative study of the structure of human and murine greater omentum.
Sylwia Wilkosz, Grenham Ireland, Nadeem Khwaja, Michael Walker, Richard Butt

Anat Embryol (Berl)· February 2005

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Increased skin collagen extractability and proportions of collagen type III are not normalized after 6 months healing of human excisional wounds.
Simon P Robins, George Milne, Alexander Duncan, Claire Davies, Richard Butt

J Invest Dermatol· August 2003

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