Publications by authors named "Robert Radinsky"

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Wild-Type Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer.
Rafael G Amado, Michael Wolf, Marc Peeters, Eric Van Cutsem, Salvatore Siena, Robert Radinsky

J Clin Oncol· June 2023

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Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo.
Gordon Moody, Brian Belmontes, Stephanie Masterman, Wei Wang, Chadwick King, Robert Radinsky

Int J Cancer· September 2016

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In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
Paul E Hughes, Karen Rex, Sean Caenepeel, Yajing Yang, Yihong Zhang, Robert Radinsky

Mol Cancer Ther· July 2016

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Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
Ryan P Wurz, Liping H Pettus, Kate Ashton, James Brown, Jian Jeffrey Chen, Robert Radinsky

ACS Med Chem Lett· September 2015

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Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.
Stephanie Geuns-Meyer, Victor J Cee, Holly L Deak, Bingfan Du, Brian L Hodous, Robert Radinsky

J Med Chem· July 2015

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The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents.
Jude Canon, Tao Osgood, Steven H Olson, Anne Y Saiki, Rebecca Robertson, Robert Radinsky

Mol Cancer Ther· March 2015

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Antagonism of Ang-Tie2 and Dll4-Notch signaling has opposing effects on tumor endothelial cell proliferation, evidenced by a new flow cytometry method.
Marc Payton, Toni Jun, William Wayne, Dongyin Yu, Raffi Manoukian, Robert Radinsky

Lab Invest· November 2014

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AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues.
Gloria Juan, Tammy L Bush, Connie Ma, Raffi Manoukian, Grace Chung, Robert Radinsky

J Transl Med· November 2014

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IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice.
Gordon Moody, Pedro J Beltran, Petia Mitchell, Elaina Cajulis, Young-Ah Chung, Robert Radinsky

J Endocrinol· April 2014

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AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models.
Tammy L Bush, Marc Payton, Scott Heller, Grace Chung, Kelly Hanestad, Robert Radinsky

Mol Cancer Ther· November 2013

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Epitope-specific mechanisms of IGF1R inhibition by ganitumab.
Frank J Calzone, Elaina Cajulis, Young-Ah Chung, Mei-Mei Tsai, Petia Mitchell, Robert Radinsky

PLoS One· July 2013

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Evaluation of the antitumor effects of rilotumumab by PET imaging in a U-87 MG mouse xenograft model.
Karen Rex, Xiaoman Z Lewis, Sundaresan Gobalakrishnan, Charles Glaus, Matthew D Silva, Robert Radinsky

Nucl Med Biol· May 2013

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Gene expression profiles can predict panitumumab monotherapy responsiveness in human tumor xenograft models.
Michael J Boedigheimer, Daniel J Freeman, Panteha Kiaei, Michael A Damore, Robert Radinsky

Neoplasia· February 2013

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Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer.
Daniel J Freeman, Kevin McDorman, Selam Ogbagabriel, Carl Kozlosky, Bing-Bing Yang, Robert Radinsky

Mol Cancer· July 2012

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Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models.
Pedro J Beltran, Young-Ah Chung, Gordon Moody, Petia Mitchell, Elaina Cajulis, Robert Radinsky

J Pharmacol Exp Ther· June 2011

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Characterization of 64Cu-DOTA-conatumumab: a PET tracer for in vivo imaging of death receptor 5.
Raffaella Rossin, Tadahiko Kohno, Aviv Hagooly, Terry Sharp, Brian Gliniak, Robert Radinsky

J Nucl Med· June 2011

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Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
John L Buchanan, John R Newcomb, David P Carney, Stuart C Chaffee, Lilly Chai, Robert Radinsky

Bioorg Med Chem Lett· April 2011

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Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Marc Payton, Tammy L Bush, Grace Chung, Beth Ziegler, Patrick Eden, Robert Radinsky

Cancer Res· December 2010

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Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody.
Angela Coxon, James Bready, Hosung Min, Stephen Kaufman, Juan Leal, Robert Radinsky

Mol Cancer Ther· October 2010

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Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
Victor J Cee, Laurie B Schenkel, Brian L Hodous, Holly L Deak, Hanh N Nguyen, Robert Radinsky

J Med Chem· September 2010

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Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth.
Josette Carnahan, Pedro J Beltran, Carol Babij, Quynh Le, Mark J Rose, Robert Radinsky

Mol Cancer Ther· August 2010

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Inhibition of RANKL increases the anti-tumor effect of the EGFR inhibitor panitumumab in a murine model of bone metastasis.
Jude Canon, Rebecca Bryant, Martine Roudier, Tao Osgood, Jon Jones, Robert Radinsky

Bone· June 2010

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Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor.
Daniel J Freeman, Tammy Bush, Selam Ogbagabriel, Brian Belmontes, Todd Juan, Robert Radinsky

Mol Cancer Ther· June 2009

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AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells.
Pedro J Beltran, Petia Mitchell, Young-A Chung, Elaina Cajulis, John Lu, Robert Radinsky

Mol Cancer Ther· May 2009

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Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met-dependent tumors in animal models.
Angela Coxon, Karen Rex, Susanne Meyer, Jianling Sun, Jilin Sun, Robert Radinsky

Mol Cancer Ther· May 2009

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