Publications by authors named "Scott Doran"

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Experimental Demonstration of Double Emittance Exchange toward Arbitrary Longitudinal Beam Phase-Space Manipulations.
Jimin Seok, Gwanghui Ha, John Power, Manoel Conde, Eric Wisniewski, Scott Doran

Phys Rev Lett· November 2022

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Transition Radiation in Photonic Topological Crystals: Quasiresonant Excitation of Robust Edge States by a Moving Charge.
Yang Yu, Kueifu Lai, Jiahang Shao, John Power, Manoel Conde, Scott Doran

Phys Rev Lett· August 2019

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Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.
Sophie Parmentier-Batteur, Julie A O'Brien, Scott Doran, Shannon J Nguyen, Rosemarie Beth Flick

Neuropharmacology· March 2012

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Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Paul J Coleman, John D Schreier, Christopher D Cox, Michael J Breslin, David B Whitman, Scott M Doran

ChemMedChem· March 2012

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Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
Christopher J Winrow, Anthony L Gotter, Christopher D Cox, Pamela L Tannenbaum, Susan L Garson, Scott M Doran

Neuropharmacology· February 2012

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Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3).
Craig A Coburn, Yunfu Luo, Mingxiang Cui, Jiabing Wang, Richard Soll, Scott M Doran

ChemMedChem· January 2012

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Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans.
William Cho, Paul Maruff, John Connell, Cindy Gargano, Nicole Calder, Scott Doran

Psychopharmacology (Berl)· December 2011

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TASK-3 as a potential antidepressant target.
Anthony L Gotter, Vincent P Santarelli, Scott M Doran, Pamela L Tannenbaum, Richard L Kraus

Brain Res· October 2011

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Pyridyl amides as potent inhibitors of T-type calcium channels.
Thomas S Reger, Zhi-Qiang Yang, Kelly-Ann S Schlegel, Youheng Shu, Christa Mattern, Scott M Doran

Bioorg Med Chem Lett· March 2011

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Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist.
Christopher J Winrow, Anthony L Gotter, Christopher D Cox, Scott M Doran, Pamela L Tannenbaum

J Neurogenet· March 2011

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Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.
Zhi-Qiang Yang, Kelly-Ann S Schlegel, Youheng Shu, Thomas S Reger, Rowena Cube, Scott Doran

ACS Med Chem Lett· December 2010

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In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.
Richard L Kraus, Yuxing Li, Yun Gregan, Anthony L Gotter, Victor N Uebele, Scott M Doran

J Pharmacol Exp Ther· November 2010

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Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists.
Kelly-Ann S Schlegel, Zhi-Qiang Yang, Thomas S Reger, Youheng Shu, Rowena Cube, Scott M Doran

Bioorg Med Chem Lett· September 2010

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Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Christopher D Cox, Michael J Breslin, David B Whitman, John D Schreier, Georgia B McGaughey, Scott M Doran

J Med Chem· July 2010

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Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.
Paul J Coleman, John D Schreier, Anthony J Roecker, Swati P Mercer, Georgia B McGaughey, Scott M Doran

Bioorg Med Chem Lett· July 2010

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Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.
James C Barrow, Kenneth E Rittle, Thomas S Reger, Zhi-Qiang Yang, Phung Bondiskey, Scott M Doran

ACS Med Chem Lett· May 2010

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Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.
Christopher J Winrow, Keith Q Tanis, Duane R Reiss, Alison M Rigby, Jason M Uslaner, Scott M Doran

Neuropharmacology· January 2010

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Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.
Victor N Uebele, Cindy E Nuss, Steven V Fox, Susan L Garson, Razvan Cristescu, Scott M Doran

Cell Biochem Biophys· December 2009

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Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
Lei Ma, Matthew A Seager, Marion Wittmann, Marlene Jacobson, Denise Bickel, Scott Doran

Proc Natl Acad Sci U S A· September 2009

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Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.
David B Whitman, Christopher D Cox, Michael J Breslin, Karen M Brashear, John D Schreier, Scott M Doran

ChemMedChem· July 2009

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Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.
Victor N Uebele, Anthony L Gotter, Cindy E Nuss, Richard L Kraus, Scott M Doran

J Clin Invest· June 2009

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Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Zhi-Qiang Yang, James C Barrow, William D Shipe, Kelly-Ann S Schlegel, Youheng Shu, Scott M Doran

J Med Chem· October 2008

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Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
William D Shipe, James C Barrow, Zhi-Qiang Yang, Craig W Lindsley, F Vivien Yang, Scott M Doran

J Med Chem· July 2008

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Evaluation of automated and semi-automated scoring of polysomnographic recordings from a clinical trial using zolpidem in the treatment of insomnia.
Vladimir Svetnik, Junshui Ma, Keith A Soper, Scott Doran, John J Renger

Sleep· November 2007

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Sleep and developmental disabilities: assessment, treatment, and outcome measures.
Scott M Doran, Mark T Harvey, Robert H Horner

Ment Retard· February 2006

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