Publications by authors named "Susan Crowell"

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Ocular Kinetics, Distribution, and Effects of Human VEGF Isoforms 121 and 165: Implications for Therapeutic Intervention.
Antonello Caruso, Judith J Mittag, Stefan Dengl, Olaf Mundigl, Uwe Wessels, Susan R Crowell

Mol Pharm· September 2025

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Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier.
Julien Lafrance-Vanasse, Shraddha S Sadekar, Yanli Yang, Daniela Bumbaca Yadav, William J Meilandt, Susan R Crowell

Nat Commun· May 2025

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Translatability of Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Phillip Y Chu, Hui Wang, Emily Ross, Nicole Stephens, Hui-Min Zhang, Susan R Crowell

Anal Chem· December 2023

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Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.
Robert F Kelley, Devin B Tesar, Yue Wang, Nicholas J Agard, Patrick G Holder, Susan R Crowell

Mol Pharm· May 2022

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Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.
Shraddha S Sadekar, Mayumi Bowen, Hao Cai, Samira Jamalian, Hanine Rafidi, Susan Crowell

Clin Pharmacol Ther· April 2022

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Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling.
Paritosh Pande, Erin P Madeen, David E Williams, Susan R Crowell, Ted J Ognibene

Toxicol Appl Pharmacol· March 2022

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Targeted IgMs agonize ocular targets with extended vitreal exposure.
Yvonne Chen, Maciej Paluch, Julie A Zorn, Sharmila Rajan, Brandon Leonard, Susan Crowell

MAbs· August 2021

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Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics.
Vittal Shivva, C Andrew Boswell, Hanine Rafidi, Robert F Kelley, Amrita V Kamath, Susan R Crowell

Front Pharmacol· May 2021

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Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy.
Edward Dere, Susan Crowell, Mauricio Maia, Chris Schuetz, Phillip Lai

Toxicol Pathol· April 2021

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Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.
Steven T Laing, Nardos Tassew, Devin Tesar, Yue Wang, Susan R Crowell

Toxicol Pathol· April 2021

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Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits.
Nardos G Tassew, Steven T Laing, Whitney Shatz, Susan R Crowell, Kelly M Loyet

Toxicol Pathol· April 2021

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Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye.
Whitney Shatz, Philip E Hass, Nikhil Peer, Maciej T Paluch, Craig Blanchette, Susan Crowell

PLoS One· February 2020

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Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ.
William J Meilandt, Janice A Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell

Alzheimers Res Ther· December 2019

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Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics.
Amin Famili, Susan R Crowell, Kelly M Loyet, Danielle Mandikian, C Andrew Boswell

Bioconjug Chem· November 2019

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Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules.
Susan R Crowell, Kathryn Wang, Amin Famili, Whitney Shatz, Kelly M Loyet

Transl Vis Sci Technol· November 2019

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Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.
Qian Gong, Meredith Hazen, Brett Marshall, Susan R Crowell, Qinglin Ou

MAbs· December 2017

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In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes.
Jordan N Smith, Denis Mehinagic, Subhasree Nag, Susan R Crowell, Richard A Corley

Toxicol Lett· March 2017

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Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.
Whitney Shatz, Philip E Hass, Mary Mathieu, Hok Seon Kim, Kim Leach, Susan R Crowell

Mol Pharm· September 2016

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Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling.
Jerry Campbell, Allison Franzen, Cynthia Van Landingham, Michael Lumpkin, Susan Crowell

Inhal Toxicol· September 2016

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A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
Jerry Campbell, Cynthia Van Landingham, Susan Crowell, Robinan Gentry, Debra Kaden

Chem Biol Interact· August 2015

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Human in Vivo Pharmacokinetics of [(14)C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Microdosing.
Erin Madeen, Richard A Corley, Susan Crowell, Kenneth Turteltaub, Ted Ognibene

Chem Res Toxicol· January 2015

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Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice.
Susan Ritger Crowell, Arun K Sharma, Shantu Amin, Jolen J Soelberg, Natalie C Sadler

Toxicol Sci· September 2013

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Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents.
Susan Ritger Crowell, Shantu G Amin, Kim A Anderson, Gowdahalli Krishnegowda, Arun K Sharma

Toxicol Appl Pharmacol· December 2011

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Translational research to develop a human PBPK models tool kit-volatile organic compounds (VOCs).
M Moiz Mumtaz, Meredith Ray, Susan R Crowell, Deborah Keys, Jeffrey Fisher

J Toxicol Environ Health A· December 2011

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Development and application of a physiologically based pharmacokinetic model for triadimefon and its metabolite triadimenol in rats and humans.
Susan Ritger Crowell, W Matthew Henderson, John F Kenneke, Jeffrey W Fisher

Toxicol Lett· August 2011

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