Publications by authors named "Tak Mak"

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PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis.
Yu Zhe Li, Joe Eun Son, Nathaniel Vo, Catherine Bellisimo, Ju Hee Lee, Tak W Mak

Nat Commun· December 2025

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PIKfyve inhibition in myeloma disrupts autophagy and the lysosome, increasing MHC expression and cholesterol metabolism.
Cecilia Bonolo De Campos, Ruijuan He, Tessa Josephine Pelino, Dor David Abelman, Zhihua Li, Tak W Mak

Blood· November 2025

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LARP4-mediated hypertranslation drives T cell dysfunction in tumors.
Yi Liu, Haochen Ni, Jie Li, Jing Yang, Ivann Sekielyk, Tak W Mak

Nat Immunol· September 2025

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Author Correction: LARP4-mediated hypertranslation drives T cell dysfunction in tumors.
Yi Liu, Haochen Ni, Jie Li, Jing Yang, Ivann Sekielyk, Tak W Mak

Nat Immunol· September 2025

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2-Methoxyestradiol Treatment Prevents Graft-versus-Host Disease While Preserving Graft-versus-Leukemia Effect in Mice.
Dan Li, Roland Bassett, Richard E Champlin, Jeffrey J Molldrem, Tak W Mak

bioRxiv· August 2025

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Cholinergic regulation of thymocyte negative selection.
Shaofeng Liu, Chunxing Zheng, Robert Nechanitzky, Ping Luo, Parameswaran Ramachandran, Tak W Mak

Nat Immunol· June 2025

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Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33.
Sara Lamorte, Rene Quevedo, Robbie Jin, Luke Neufeld, Zhe Qi Liu, Tak W Mak

Cancer Cell· May 2025

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B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8 T cell function.
Nastaran Fazel Modares, Liam D Hendrikse, Logan K Smith, Michael St Paul, Jillian Haight, Tak W Mak

Immunity· May 2025

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Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT.
Chunxing Zheng, Shaofeng Liu, Nastaran Fazel Modares, Michael St Paul, Tak W Mak

Nat Immunol· May 2025

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Mutant cooperates with or to drive distinct myeloid diseases and molecular outcomes.
Takashi Sakamoto, Julie Leca, Xin Zhang, Cem Meydan, Jonathan Foox, Tak W Mak

Proc Natl Acad Sci U S A· May 2025

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B cell-derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor-mediated signaling.
Erica Foffi, Francesco Rugolo, Nisha Ramamurthy, Jillian Haight, Simone Helke, Tak W Mak

Proc Natl Acad Sci U S A· April 2025

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The IDH1-R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction.
Kunmei Lai, Zhimin Chen, Siyi Lin, Keng Ye, Ying Yuan, Tak W Mak

Cell Death Differ· February 2025

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Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification.
Christopher Zhang, Benson Z Wu, Caterina Di Ciano-Oliveira, Yin Fang Wu, Sharon S Khavkine Binstock, Tak W Mak

Cancer Gene Ther· October 2024

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Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair-Deficient Uterine Leiomyosarcoma.
Horace H Y Lee, Kin Long Chow, Ho Shing Wong, Tsz Yan Chong, Alice S T Wong, Tak Wah Mak

Clin Cancer Res· September 2024

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Development of a highly sensitive platform for protein-protein interaction detection and regulation of T cell function.
Hideki Hayashi, Tak Wah Mak, Yoshimasa Tanaka, Yoshinao Kubo, Mai Izumida

Proc Natl Acad Sci U S A· August 2024

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Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma.
Avishay Spitzer, Simon Gritsch, Masashi Nomura, Alexander Jucht, Jerome Fortin, Tak W Mak

Cancer Cell· May 2024

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Correction: Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development.
Masahito Kawazu, Kayoko Saso, Kit I Tong, Tracy McQuire, Kouichiro Goto, Makoto Miyagishi, Tak W Mak

PLoS One· May 2024

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Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms.
Tracy Murphy, Jacqueline M Mason, Brian Leber, Mark R Bray, Steven M Chan, Tak W Mak

Leukemia· March 2024

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CaSSiDI: novel single-cell "Cluster Similarity Scoring and Distinction Index" reveals critical functions for PirB and context-dependent Cebpb repression.
Robert Nechanitzky, Parameswaran Ramachandran, Duygu Nechanitzky, Wanda Y Li, Andrew C Wakeham, Tak W Mak

Cell Death Differ· March 2024

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Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy.
Michael St Paul, Samuel D Saibil, Meghan Kates, SeongJun Han, Scott C Lien, Tak W Mak

Cell Rep Med· March 2024

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Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML.
Cheuk-Him Man, Wing Lam, Chee-Chean Dang, Xiao-Yuan Zeng, Li-Chuan Zheng, Tak Wah Mak

Blood· December 2023

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Tumor-specific cholinergic CD4 T lymphocytes guide immunosurveillance of hepatocellular carcinoma.
Chunxing Zheng, Bryan E Snow, Andrew J Elia, Robert Nechanitzky, Carmen Dominguez-Brauer, Tak W Mak

Nat Cancer· October 2023

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Chemical carcinogens: implications for cancer treatment.
Shaofeng Liu, Mary Saunders, Tak W Mak

J Clin Invest· October 2023

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Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.
Hong Yu, Liam J Worrall, Thorsten Berger, Martin Petric, Bryan H Lin, Tak Mak

J Immunol· September 2023

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HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.
Joelle S Suarez, Flavia Novelli, Keisuke Goto, Michiko Ehara, Mika Steele, Tak W Mak

Proc Natl Acad Sci U S A· September 2023

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