Publications by authors named "Tim Dafforn"

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RePol: A high-throughput screen for optimizing membrane protein solubilization and purification using polymers.
Adam Evans, Bethan Kelly, Pooja Sridhar, Alice J Rothnie, Naomi L Pollock, Tim R Dafforn

Protein Sci· January 2026

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In-line circular dichroism and fluorescence for real-time monitoring of monoclonal antibody structure during affinity chromatography.
Charles Moore-Kelly, Alison Rodger, Tim R Dafforn, Owen R T Thomas

J Chromatogr A· August 2025

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Analysis of the Structure of 14 Therapeutic Antibodies Using Circular Dichroism Spectroscopy.
Maria G Bruque, Alison Rodger, Søren Vrønning Hoffmann, Nykola C Jones, Jean Aucamp, Tim R Dafforn

Anal Chem· September 2024

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The mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs.
Sara Cioccolo, Joseph D Barritt, Naomi Pollock, Zoe Hall, Julia Babuta, Tim Dafforn

RSC Chem Biol· August 2024

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GPCRs in the round: SMA-like copolymers and SMALPs as a platform for investigating GPCRs.
Hoor Ayub, Rebecca J Murray, Gestél C Kuyler, Farhaan Napier-Khwaja, Joseph Gunner, Tim R Dafforn

Arch Biochem Biophys· April 2024

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Purification and characterisation of the platelet-activating GPVI/FcRγ complex in SMALPs.
Xueqing Wang, Alexandre Slater, Sarah C Lee, Neale Harrison, Naomi L Pollock, Tim R Dafforn

Arch Biochem Biophys· April 2024

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The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study.
Stephen C L Hall, Cecilia Tognoloni, Richard A Campbell, Joanna Richens, Paul O'Shea, Tim R Dafforn

J Colloid Interface Sci· November 2022

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Biophysical characterisation of SMALPs.
Stephanie A Nestorow, Tim R Dafforn, Verna Frasca

Biochem Soc Trans· November 2021

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Differences in SMA-like polymer architecture dictate the conformational changes exhibited by the membrane protein rhodopsin encapsulated in lipid nano-particles.
Rachael L Grime, Richard T Logan, Stephanie A Nestorow, Pooja Sridhar, Patricia C Edwards, Tim R Dafforn

Nanoscale· August 2021

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Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier.
José Edwin Neciosup Quesñay, Naomi L Pollock, Raghavendra Sashi Krishna Nagampalli, Sarah C Lee, Vijayakumar Balakrishnan, Tim R Dafforn

Biology (Basel)· November 2020

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Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer.
Stephen C L Hall, Luke A Clifton, Cecilia Tognoloni, Kerrie A Morrison, Timothy J Knowles, Tim R Dafforn

J Colloid Interface Sci· August 2020

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Releasing the technical 'shackles' on GPCR drug discovery: opportunities enabled by detergent-free polymer lipid particle (PoLiPa) purification.
J Daniel Hothersall, Andrew Y Jones, Tim R Dafforn, Trevor Perrior, Kathryn L Chapman

Drug Discov Today· August 2020

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Ligand-induced conformational changes in a SMALP-encapsulated GPCR.
Sarah J Routledge, Mohammed Jamshad, Haydn A Little, Yu-Pin Lin, John Simms, Tim R Dafforn

Biochim Biophys Acta Biomembr· June 2020

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Pandemic research: UK must coordinate.
Tim R Dafforn

Nature· June 2020

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Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure.
Charles Moore-Kelly, John Welsh, Alison Rodger, Tim R Dafforn, Owen R T Thomas

Anal Chem· November 2019

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SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis.
Naomi L Pollock, Megha Rai, Kailene S Simon, Sophie J Hesketh, Alvin C K Teo, Tim R Dafforn

Biochim Biophys Acta Biomembr· August 2019

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Purification of membrane proteins free from conventional detergents: SMA, new polymers, new opportunities and new insights.
Zoe Stroud, Stephen C L Hall, Tim R Dafforn

Methods· September 2018

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An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles.
Stephen C L Hall, Cecilia Tognoloni, Jack Charlton, Éilís C Bragginton, Alice J Rothnie, Tim R Dafforn

Nanoscale· June 2018

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Influence of Poly(styrene- co-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs.
Stephen C L Hall, Cecilia Tognoloni, Gareth J Price, Bert Klumperman, Karen J Edler, Tim R Dafforn

Biomacromolecules· March 2018

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Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG-SecDF-YajC-YidC.
Joanna Komar, Sara Alvira, Ryan J Schulze, Remy Martin, Jelger A Lycklama A Nijeholt, Tim R Dafforn

Biochem J· October 2016

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GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.
Mark Wheatley, Jack Charlton, Mohammed Jamshad, Sarah J Routledge, Sian Bailey, Tim R Dafforn

Biochem Soc Trans· April 2016

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G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.
Mohammed Jamshad, Jack Charlton, Yu-Pin Lin, Sarah J Routledge, Zharain Bawa, Tim R Dafforn

Biosci Rep· April 2015

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Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins.
Mohammed Jamshad, Vinciane Grimard, Ilaria Idini, Tim J Knowles, Miriam R Dowle, Tim R Dafforn

Nano Res· March 2015

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The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy.
Vincent Postis, Shaun Rawson, Jennifer K Mitchell, Sarah C Lee, Rosemary A Parslow, Tim R Dafforn

Biochim Biophys Acta· February 2015

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Surfactant-free purification of membrane proteins with intact native membrane environment.
Mohammed Jamshad, Yu-Pin Lin, Timothy J Knowles, Rosemary A Parslow, Craig Harris, Tim R Dafforn

Biochem Soc Trans· June 2011

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