Publications by authors named "Tim Menzen"

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Inline optical cell alignment inspection (IOCAI) improves data quality in sedimentation-velocity analytical ultracentrifugation experiments.
Valerija Vezočnik, Tim Menzen, Andrea Hawe, Klaus Richter

J Pharm Sci· December 2025

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Quality (Attributes) over quantity: Minimal essential quality attributes for determining antibody stability in postproduction handling stability studies.
Roderick van den Berg, Renske Penning, Reza Nejadnik, Wim Jiskoot, Tim Menzen

J Pharm Sci· December 2025

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To platform or not to platform: Strategic considerations for antibody formulation in early clinical development.
Tim Menzen, Kristian Le Vay, Andrea Arsiccio, Constanze Helbig, Kerstin Hausmann

J Pharm Sci· November 2025

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Running on the verge of collapse in lyophilization: What is the impact of the edge vial effect on colloidal protein stability and particle morphology?
Dominik Brandstetter, Andrea Arsiccio, Andrea Hawe, Hristo L Svilenov, Tim Menzen

J Pharm Sci· July 2025

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Additivity of Transfer Free Energies Enables the Description of Complex Protein Formulations in Implicit Solvent Molecular Dynamics Simulations.
Dominik Brandstetter, Max Unger, Tim Menzen, Hristo L Svilenov, Andrea Arsiccio

Mol Pharm· July 2025

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Direct comparison of single peak and gradient chromatographic methods for routine analysis of surfactants in biopharmaceuticals.
Maksymilian M Zegota, Juliane Achenbach, Georg Schuster, Christian Schöneich, Tim Menzen

Eur J Pharm Sci· June 2025

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Stability of Jurkat cells during short-term liquid storage analyzed by flow imaging microscopy.
Alexandra Roesch, Cornelia Hiemenz, Teresa Findley, Ilya Goldberg, Roland Windisch, Tim Menzen

Eur J Pharm Biopharm· June 2025

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Reducing dimethyl sulfoxide content in Jurkat cell formulations suitable for cryopreservation.
Alexandra Roesch, Roland Windisch, Christian Wichmann, Willem F Wolkers, Gideon Kersten, Tim Menzen

Cryobiology· June 2025

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Is Lyophilization Key for Transportation and Storage of Biopharmaceutical Drug Products in Space?
Tim Menzen

J Pharm Sci· July 2024

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Challenges in the analysis of pharmaceutical lentiviral vector products by orthogonal and complementary physical (nano)particle characterization techniques.
Daniela Stadler, Constanze Helbig, Klaus Wuchner, Jürgen Frank, Klaus Richter, Tim Menzen

Eur J Pharm Biopharm· July 2024

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Three-Dimensional Homodyne Light Detection (3D-HLD) for High-Throughput Submicron Particle Analysis in (Highly Concentrated) Protein Biopharmaceuticals, Viral Vectors, and LNPs.
Dominik Brandstetter, Constanze Helbig, Kentaro Osawa, Hiroyuki Minemura, Yumiko Anzai, Tim Menzen

J Pharm Sci· April 2024

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High throughput multidimensional liquid chromatography approach for online protein removal and characterization of polysorbates and poloxamer in monoclonal antibody formulations.
Maksymilian M Zegota, Georg Schuster, Mauro De Pra, Tibor Müllner, Tim Menzen

J Chromatogr A· April 2024

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A model-based optimization strategy to achieve fast and robust freeze-drying cycles.
Brecht Vanbillemont, Anna-Lena Greiner, Vanessa Ehrl, Tim Menzen, Wolfgang Friess

Int J Pharm X· December 2023

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Osmotic properties of T cells determined by flow imaging microscopy in comparison to electrical sensing zone analysis.
Alexandra Roesch, Roland Windisch, Christian Wichmann, Willem F Wolkers, Gideon Kersten, Tim Menzen

Cryobiology· December 2023

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Genome length determination in adeno-associated virus vectors with mass photometry.
Cornelia Hiemenz, Nadine Baumeister, Constanze Helbig, Andrea Hawe, Sabrina Babutzka, Tim Menzen

Mol Ther Methods Clin Dev· December 2023

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Possibilities and limitations of α-relaxation data of amorphous freeze-dried cakes to predict long term IgG antibody stability.
Sebastian Groël, Tim Menzen, Gerhard Winter

Int J Pharm· November 2023

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Evaluating the chaos game representation of proteins for applications in machine learning models: prediction of antibody affinity and specificity as a case study.
Andrea Arsiccio, Lorenzo Stratta, Tim Menzen

J Mol Model· November 2023

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Purity and DNA content of AAV capsids assessed by analytical ultracentrifugation and orthogonal biophysical techniques.
Klaus Richter, Christine Wurm, Kim Strasser, Jana Bauer, Maria Bakou, Tim Menzen

Eur J Pharm Biopharm· August 2023

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Characterization of Virus Particles and Submicron-Sized Particulate Impurities in Recombinant Adeno-Associated Virus Drug Product.
Cornelia Hiemenz, Anabel Pacios-Michelena, Constanze Helbig, Valerija Vezočnik, Michael Strebl, Tim Menzen

J Pharm Sci· August 2023

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Prediction of Unwanted Crystallization of Freeze-Dried Protein Formulations Using α-Relaxation Measurements.
Sebastian Groël, Tim Menzen, Gerhard Winter

Pharmaceutics· February 2023

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SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs.
Anian Thaller, Lukas Schmauder, Wolfgang Frieß, Gerhard Winter, Tim Menzen

Eur J Pharm Biopharm· January 2023

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Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties.
Hristo L Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier, Pietro Sormanni

MAbs· January 2023

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An Interlaboratory Study to Identify Potential Visible Protein-Like Particle Standards.
Srivalli N Telikepalli, Michael J Carrier, Dean C Ripple, Greg Barnett, Ashwinkumar Bhirde, Tim Menzen

AAPS PharmSciTech· December 2022

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Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals.
Haruka Nishiumi, Natalie Deiringer, Nils Krause, Saki Yoneda, Tetsuo Torisu, Tim Menzen

J Pharm Sci· November 2022

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Understanding opalescence measurements of biologics - A comparison study of methods, standards, and molecules.
Patrick Kunz, Eva Stuckenberger, Kerstin Hausmann, Lorenzo Gentiluomo, Malene Neustrup, Tim Menzen

Int J Pharm· November 2022

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