Publications by authors named "Tony P Tang"

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Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
Quinn A Bumpers, Robert W Pipal, Anna M Benz-Weeden, James T Brewster, Adam Cook, Tony P Tang

J Med Chem· August 2024

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Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS Inhibitor.
Xiaolun Wang, Shelley Allen, James F Blake, Vickie Bowcut, David M Briere, Tony P Tang

J Med Chem· February 2022

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Identification of the Clinical Development Candidate , a Covalent KRAS Inhibitor for the Treatment of Cancer.
Jay B Fell, John P Fischer, Brian R Baer, James F Blake, Karyn Bouhana, Tony P Tang

J Med Chem· July 2020

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Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
Jay B Fell, John P Fischer, Brian R Baer, Joshua Ballard, James F Blake, Tony P Tang

ACS Med Chem Lett· December 2018

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Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.
Maria-Jesus Blanco, Dana R Benesh, James A Knobelsdorf, Albert Khilevich, Guillermo S Cortez, Tony P Tang

Bioorg Med Chem Lett· January 2017

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Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.
Tomoaki Hasui, Norio Ohyabu, Taiichi Ohra, Koji Fuji, Takahiro Sugimoto, Tony P Tang

Bioorg Med Chem· October 2014

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Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.
Allen A Thomas, Kevin W Hunt, Matthew Volgraf, Ryan J Watts, Xingrong Liu, Tony P Tang

J Med Chem· February 2014

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Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.
Tomoaki Hasui, Taiichi Ohra, Norio Ohyabu, Kouhei Asano, Hideki Matsui, Tony P Tang

Bioorg Med Chem· October 2013

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Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.
Kevin W Hunt, Adam W Cook, Ryan J Watts, Christopher T Clark, Guy Vigers, Tony P Tang

J Med Chem· April 2013

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Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.
Tomoaki Hasui, Nobuyuki Matsunaga, Taiichi Ora, Norio Ohyabu, Nobuhiro Nishigaki, Tony P Tang

J Med Chem· December 2011

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Development and application of a new general method for the asymmetric synthesis of syn- and anti-1,3-amino alcohols.
Takuya Kochi, Tony P Tang, Jonathan A Ellman

J Am Chem Soc· September 2003

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Asymmetric synthesis of beta-amino acid derivatives incorporating a broad range of substitution patterns by enolate additions to tert-butanesulfinyl imines.
Tony P Tang, Jonathan A Ellman

J Org Chem· November 2002

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N-tert-butanesulfinyl imines: versatile intermediates for the asymmetric synthesis of amines.
Jonathan A Ellman, Timothy D Owens, Tony P Tang

Acc Chem Res· November 2002

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Asymmetric synthesis of syn- and anti-1,3-amino alcohols.
Takuya Kochi, Tony P Tang, Jonathan A Ellman

J Am Chem Soc· June 2002

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The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of beta-Amino Acids.
Tony P. Tang, Jonathan A. Ellman

J Org Chem· January 1999

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