Publications by authors named "Tracy Zimmermann"

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Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.
Maja M Janas, Ivan Zlatev, Ju Liu, Yongfeng Jiang, Scott A Barros, Tracy Zimmermann

Nucleic Acids Res· April 2019

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Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.
Jennifer L S Willoughby, Amy Chan, Alfica Sehgal, James S Butler, Jayaprakash K Nair, Tracy S Zimmermann

Mol Ther· January 2018

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Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.
Jayaprakash K Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Tracy Zimmermann

Nucleic Acids Res· November 2017

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Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.
Zhongbo Liu, Tianzhen Han, Shannon Fishman, James Butler, Tracy Zimmermann

Endocrinology· August 2017

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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.
Tracy S Zimmermann, Verena Karsten, Amy Chan, Joseph Chiesa, Malcolm Boyce

Mol Ther· January 2017

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Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.
James S Butler, Amy Chan, Susete Costelha, Shannon Fishman, Jennifer L S Willoughby, Tracy S Zimmermann

Amyloid· June 2016

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Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
Jayaprakash K Nair, Jennifer L S Willoughby, Amy Chan, Klaus Charisse, Md Rowshon Alam, Tracy Zimmermann

J Am Chem Soc· December 2014

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Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation.
Kate E Broderick, Amy Chan, Feng Lin, Xuefei Shen, Gleb Kichaev, Tracy S Zimmermann

Mol Ther Nucleic Acids· February 2012

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N Anderson, Timothy S Racie, Birgit Bramlage, Tracy Zimmermann

Proc Natl Acad Sci U S A· August 2008

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.
Akin Akinc, Andreas Zumbuehl, Michael Goldberg, Elizaveta S Leshchiner, Valentina Busini, Tracy S Zimmermann

Nat Biotechnol· May 2008

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.
Christian Wolfrum, Shuanping Shi, K Narayanannair Jayaprakash, Muthusamy Jayaraman, Gang Wang, Tracy Zimmermann

Nat Biotechnol· October 2007

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RNAi-mediated gene silencing in non-human primates.
Tracy S Zimmermann, Amy C H Lee, Akin Akinc, Birgit Bramlage, David Bumcrot

Nature· May 2006

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