Publications by authors named "William Reagan"

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Circulating microRNAs as promising testicular translatable safety biomarkers: current state and future perspectives.
Jiangwei Zhang, Sarah Campion, Natasha Catlin, William J Reagan, Kiran Palyada

Arch Toxicol· April 2023

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To Clot or Not to Clot: Deepening Our Understanding of Alterations in the Hemostatic System.
William J Reagan, Marjory B Brooks, Renata Grozovsky, Debra Pittman, Allison Vitsky

Toxicol Pathol· October 2022

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Gemtuzumab Ozogamicin Treatment Results in Decreased Proliferation and Differentiation of Human Megakaryocytes but Does Not Inhibit Mature Platelet Function.
Allison Vitsky, Aida Sacaan, Wenyue Hu, Martin Finkelstein, William Reagan

Toxicol Pathol· October 2022

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Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™.
Jean G Sathish, Siddhartha Bhatt, Jamie K DaSilva, Declan Flynn, Stephen Jenkinson, William J Reagan

Int J Toxicol· August 2022

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The use of emerging safety biomarkers in nonclinical and clinical safety assessment - The current and future state: An IQ DruSafe industry survey.
Tanja S Zabka, John Burkhardt, William J Reagan, Jean-Charles Gautier, Warren E Glaab

Regul Toxicol Pharmacol· March 2021

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De novo lipogenesis is essential for platelet production in humans.
Kenneth L Kelly, William J Reagan, Gabriele E Sonnenberg, Michelle Clasquin, Katherine Hales

Nat Metab· October 2020

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Evaluation of Rat Acute Phase Proteins as Inflammatory Biomarkers for Vaccine Nonclinical Safety Studies.
William J Reagan, Ahmed M Shoieb, Shelli J Schomaker, Victoria R Markiewicz, David W Clarke

Toxicol Pathol· October 2020

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Confounding Factors in the Interpretation of Preclinical Studies.
Laura Dill Morton, Martin Sanders, William J Reagan, Torrie A Crabbs, Maralee McVean

Int J Toxicol· January 2020

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Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments.
Kathryn E Gropp, Cathy S Carlson, Mark G Evans, Cedo M Bagi, William J Reagan

Toxicol Pathol· June 2018

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Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption.
Kristen Johnson, Kymberly Levine, Joseph Sergi, Jean Chamoun, Rachel Roach, William Reagan

J Bone Miner Res· October 2017

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Liver Microvascular Injury and Thrombocytopenia of Antibody-Calicheamicin Conjugates in Cynomolgus Monkeys-Mechanism and Monitoring.
Magali Guffroy, Hadi Falahatpisheh, Kathleen Biddle, John Kreeger, Leslie Obert, William Reagan

Clin Cancer Res· April 2017

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Inflammatory Cell Findings in the Female Rabbit Heart and Stress-associated Exacerbation with Handling and Procedures Used in Nonclinical Studies.
Rani S Sellers, Ingrid Pardo, George Hu, K Nasir Khan, Richard Perry, William Reagan

Toxicol Pathol· April 2017

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Assessment of Cardiac Troponin I Responses in Nonhuman Primates during Restraint, Blood Collection, and Dosing in Preclinical Safety Studies.
William J Reagan, Robert Barnes, Peter Harris, Sandy Summers, Sarah Lopes

Toxicol Pathol· February 2017

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Principles for Assessing Adversity in Toxicologic Clinical Pathology.
Lila Ramaiah, Lindsay Tomlinson, Niraj K Tripathi, Laura C Cregar, Allison Vitsky, William J Reagan

Toxicol Pathol· February 2017

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Evaluation of Cardiac Toxicity Biomarkers in Rats from Different Laboratories.
Kyuri Kim, Naseem Chini, David G Fairchild, Steven K Engle, William J Reagan

Toxicol Pathol· December 2016

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Cross-laboratory analytical validation of the cardiac biomarker NT-proANP in rat.
Petra Vinken, William J Reagan, Luis A Rodriguez, Wayne R Buck, Jie Lai-Zhang

J Pharmacol Toxicol Methods· September 2016

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Evaluation of urinary corticosterone as a biomarker of stress in rats using fenitrothion as a chemical stressor.
Jean-Martin Lapointe, Patricia A Snyder, William J Reagan

J Immunotoxicol· May 2016

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Comparison of cardiac troponin I and T, including the evaluation of an ultrasensitive assay, as indicators of doxorubicin-induced cardiotoxicity.
William J Reagan, Malcolm York, Brian Berridge, Eric Schultze, Dana Walker

Toxicol Pathol· August 2014

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Toxicities associated with 1-month treatment with propylthiouracil (PTU) and methimazole (MMI) in male rats.
Prashant R Nambiar, Gopinath S Palanisamy, Carlin Okerberg, Angela Wolford, Karen Walters, William J Reagan

Toxicol Pathol· August 2014

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The American Society for Veterinary Clinical Pathology Regulatory Affairs Committee's clinical pathology best practices recommendations will impact the discipline of veterinary toxicologic clinical pathology.
William J Reagan

Vet Clin Pathol· September 2013

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The inhibin B response in male rats treated with two drug candidates.
Robert E Chapin, James D Alvey, Richard A Goldstein, Melba G Dokmanovich, William J Reagan

Birth Defects Res B Dev Reprod Toxicol· February 2013

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Analytic evaluation of a human ELISA kit for measurement of inhibin B in rat samples.
Michelle Coulson, Sue Bickerton, Catherine J Betts, Matt Jacobsen, Jane Stewart, William J Reagan

Birth Defects Res B Dev Reprod Toxicol· February 2013

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Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat.
Robert Chapin, Gerhard Weinbauer, Michael S Thibodeau, Manisha Sonee, Louise Parks Saldutti, William J Reagan

Birth Defects Res B Dev Reprod Toxicol· February 2013

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Response letter from Clinical Pathology Interest Group of the Society of Toxicologic Pathology (STP) for manuscript entitled International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies by Bolon et al.
Niraj K Tripathi, A Eric Schultze, Renee C Pearson, Nancy E Everds, Glenn S Elliott, William J Reagan

Exp Toxicol Pathol· January 2013

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Metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice treated with dexamethasone.
William J Reagan, Rong-Ze Yang, Soohyun Park, Richard Goldstein, Dominique Brees

Toxicol Pathol· December 2012

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