Publications by authors named "Wing-Lee Chan"

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A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia.
Jean Jacobs, Hristiana Lyubenova, Sven Potelle, Johannes Kopp, Isabelle Gerin, Wing Lee Chan

Nature· October 2025

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Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes.
Juliane Glaser, Giulia Cova, Beatrix Fauler, Cesar A Prada-Medina, Virginie Stanislas, Wing-Lee Chan

Nat Genet· July 2025

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Endogenous dysregulated energy and amino acid metabolism delay scaffold-guided large volume bone regeneration in a diabetic rat model with Leptin receptor deficiency.
Daniela B Dias, WingLee Chan, Agnes Ellinghaus, Raphaela Fritsche-Guenther, Janine Wiebach

Acta Biomater· June 2025

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Single-cell, whole-embryo phenotyping of mammalian developmental disorders.
Xingfan Huang, Jana Henck, Chengxiang Qiu, Varun K A Sreenivasan, Saranya Balachandran, Wing-Lee Chan

Nature· November 2023

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Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.
Lila Allou, Sara Balzano, Andreas Magg, Mathieu Quinodoz, Beryl Royer-Bertrand, Wing-Lee Chan

Nature· April 2021

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Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture.
Alexandra Despang, Robert Schöpflin, Martin Franke, Salaheddine Ali, Ivana Jerković, Wing-Lee Chan

Nat Genet· August 2019

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GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation.
Tomasz M Witkos, Wing Lee Chan, Merja Joensuu, Manuel Rhiel, Ed Pallister

Nat Commun· January 2019

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Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.
Bjørt K Kragesteen, Malte Spielmann, Christina Paliou, Verena Heinrich, Robert Schöpflin, Wing-Lee Chan

Nat Genet· October 2018

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Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.
Wing Lee Chan, Magdalena Steiner, Tomasz Witkos, Johannes Egerer, Björn Busse, Danny Chan

PLoS Genet· March 2018

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Examining tissue composition, whole-bone morphology and mechanical behavior of Gorab mice tibiae: A mouse model of premature aging.
Haisheng Yang, Laia Albiol, Wing-Lee Chan, Dag Wulsten, Anne Seliger

J Biomech· December 2017

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Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog).
Anja J Will, Giulia Cova, Marco Osterwalder, Wing-Lee Chan, Lars Wittler

Nat Genet· October 2017

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Formation of new chromatin domains determines pathogenicity of genomic duplications.
Martin Franke, Daniel M Ibrahim, Guillaume Andrey, Wibke Schwarzer, Verena Heinrich, Wing-Lee Chan

Nature· October 2016

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Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.
Malte Spielmann, Naseebullah Kakar, Naeimeh Tayebi, Catherine Leettola, Gudrun Nürnberg, Wing Lee Chan

Genome Res· February 2016

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GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.
Johannes Egerer, Denise Emmerich, Björn Fischer-Zirnsak, Wing Lee Chan, David Meierhofer

J Invest Dermatol· October 2015

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Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice.
Katerina Kraft, Sinje Geuer, Anja J Will, Wing Lee Chan, Christina Paliou

Cell Rep· February 2015

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Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.
Stefanie Weinert, Sabrina Jabs, Svea Hohensee, Wing Lee Chan, Uwe Kornak

EMBO Rep· July 2014

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Properties of beta-propeller phytase expressed in transgenic tobacco.
Wing-Lee Chan, Shiu-Cheung Lung, Boon L Lim

Protein Expr Purif· March 2006

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