Publications by authors named "Alan Watt"

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Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson's Disease.
Nicholas Clarke, Peter Thornton, Valérie Reader, Nicola Lindsay, Zsofia Digby, Alan P Watt

Mov Disord· October 2025

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Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an tool compound for neuroinflammatory disorders.
David Harrison, Andy Billinton, Mark G Bock, Nicholas P Clarke, Zsofia Digby, Alan P Watt

RSC Med Chem· September 2025

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The NLRP3 inhibitor NT-0796 enhances and sustains GLP-1R agonist-mediated weight loss in a murine diet-induced obesity model.
Peter Thornton, Valérie Reader, Zsofia Digby, John Doedens, Nicola Lindsay, Alan P Watt

Obesity (Silver Spring)· July 2025

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The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1.
John R Doedens, Christine Diamond, David Harrison, Mark G Bock, Nicholas Clarke, Alan P Watt

Biochem Pharmacol· September 2024

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Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1-pyrazol-4-yl)({[(2)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.
John R Doedens, Pamela Smolak, MyTrang Nguyen, Heather Wescott, Christine Diamond, Alan P Watt

ACS Pharmacol Transl Sci· May 2024

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Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency.
Pamela Smolak, MyTrang Nguyen, Christine Diamond, Heather Wescott, John R Doedens, Alan P Watt

J Pharmacol Exp Ther· February 2024

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Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796.
Peter Thornton, Valérie Reader, Zsofia Digby, Pamela Smolak, Nicola Lindsay, Alan P Watt

J Pharmacol Exp Ther· February 2024

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Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders.
David Harrison, Andy Billinton, Mark G Bock, John R Doedens, Christopher A Gabel, Alan P Watt

J Med Chem· November 2023

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Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors.
David Harrison, Mark G Bock, John R Doedens, Christopher A Gabel, M Katharine Holloway, Alan P Watt

ACS Med Chem Lett· August 2022

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Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.
David Harrison, Nicolas Boutard, Krzysztof Brzozka, Marta Bugaj, Stefan Chmielewski, Alan P Watt

Bioorg Med Chem Lett· December 2020

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Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function.
Alexandre Bignon, Alan P Watt, Michelle A Linterman

Front Immunol· May 2017

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CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.
Andrew D Cansfield, Tammy Ladduwahetty, Mihiro Sunose, Katie Ellard, Rosemary Lynch, Alan P Watt

ACS Med Chem Lett· August 2016

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A randomized, double-blind, crossover comparison of MK-0929 and placebo in the treatment of adults with ADHD.
Anna Rivkin, Robert C Alexander, Jennifer Knighton, Pete H Hutson, Xiaojing J Wang, Alan P Watt

J Atten Disord· November 2012

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Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
Andrew Pike, Susan M Cook, Alan P Watt, Paul Scott-Stevens, Thomas W Rosahl

Biopharm Drug Dispos· September 2007

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Utility of long-term cultured human hepatocytes as an in vitro model for cytochrome p450 induction.
Georgina Meneses-Lorente, Christine Pattison, Claire Guyomard, Christophe Chesné, Robert Heavens, Alan P Watt

Drug Metab Dispos· February 2007

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A quantitative high-throughput trapping assay as a measurement of potential for bioactivation.
Georgina Meneses-Lorente, Melanie Zea Sakatis, Timothy Schulz-Utermoehl, Claudio De Nardi, Alan P Watt

Anal Biochem· April 2006

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Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering.
Barry D Moore, Lorna Stevenson, Alan Watt, Sabine Flitsch, Nicolas J Turner

Nat Biotechnol· September 2004

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A proteomic investigation of drug-induced steatosis in rat liver.
Georgina Meneses-Lorente, Paul C Guest, Jeffrey Lawrence, Nagaraja Muniappa, Michael R Knowles, Alan Watt

Chem Res Toxicol· May 2004

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Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
David C Evans, Alan P Watt, Deborah A Nicoll-Griffith, Thomas A Baillie

Chem Res Toxicol· January 2004

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Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets.
Su-Er W Huskey, Brian J Dean, Ray Bakhtiar, Rosa I Sanchez, F David Tattersall, Alan P Watt

Drug Metab Dispos· June 2003

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Metabolite identification in drug discovery.
Alan P Watt, Russell J Mortishire-Smith, Ute Gerhard, Steven R Thomas

Curr Opin Drug Discov Devel· January 2003

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Enantiomeric separation of substituted 2-arylindoles on derivatised polysaccharide chiral stationary phases.
Alan P Watt, Laure Hitzel, Russell J Mortishire-Smith

J Biochem Biophys Methods· December 2002

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Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.
Cornelis E C A Hop, Yanfeng Wang, Sanjeev Kumar, Maria Victoria Silva Elipe, Conrad E Raab, Alan P Watt

Drug Metab Dispos· August 2002

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Determination of drug concentrations in plasma by a highly automated, generic and flexible protein precipitation and liquid chromatography/tandem mass spectrometry method applicable to the drug discovery environment.
Desmond O'Connor, Dawn E Clarke, Denise Morrison, Alan P Watt

Rapid Commun Mass Spectrom· July 2002

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An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis.
Denise Morrison, Amy E Davies, Alan P Watt

Anal Chem· April 2002

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