Publications by authors named "Alison Woolford"

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Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.
Thomas D Downes, S Paul Jones, James D Firth, John F Darby, Amelia K Gilio, Alison J-A Woolford

Chem Sci· October 2025

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Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.
S Paul Jones, James D Firth, Mary C Wheldon, Masakazu Atobe, Roderick E Hubbard, Alison J-A Woolford

RSC Med Chem· December 2022

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Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Emiliano Tamanini, Shin Miyamura, Ildiko M Buck, Benjamin D Cons, Lee Dawson, Alison J-A Woolford

ACS Med Chem Lett· October 2022

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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
David Norton, William G Bonnette, James F Callahan, Maria G Carr, Charlotte M Griffiths-Jones, Alison J-A Woolford

J Med Chem· November 2021

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ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK.
Joanne M Munck, Valerio Berdini, Luke Bevan, Jessica L Brothwood, Juan Castro, Alison J-A Woolford

Mol Cancer Ther· October 2021

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Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Tom D Heightman, Valerio Berdini, Luke Bevan, Ildiko M Buck, Maria G Carr, Alison J-A Woolford

J Med Chem· August 2021

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Design and Synthesis of 56 Shape-Diverse 3D Fragments.
Thomas D Downes, S Paul Jones, Hanna F Klein, Mary C Wheldon, Masakazu Atobe, Alison J-A Woolford

Chemistry· July 2020

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Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
Tom D Heightman, James F Callahan, Elisabetta Chiarparin, Joseph E Coyle, Charlotte Griffiths-Jones, Alison J-A Woolford

J Med Chem· May 2019

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Assessment of Digital PCR as a Primary Reference Measurement Procedure to Support Advances in Precision Medicine.
Alexandra S Whale, Gerwyn M Jones, Jernej Pavšič, Tanja Dreo, Nicholas Redshaw, Alison J Woolford

Clin Chem· September 2018

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Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Tom D Heightman, Valerio Berdini, Hannah Braithwaite, Ildiko M Buck, Megan Cassidy, Alison J-A Woolford

J Med Chem· June 2018

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Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA).
Alison J-A Woolford, Philip J Day, Véronique Bénéton, Valerio Berdini, Joseph E Coyle

J Med Chem· December 2016

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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
Alison J-A Woolford, Joseph E Pero, Sridhar Aravapalli, Valerio Berdini, Joseph E Coyle

J Med Chem· June 2016

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Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
Thomas G Davies, William E Wixted, Joseph E Coyle, Charlotte Griffiths-Jones, Keisha Hearn, Alison J-A Woolford

J Med Chem· April 2016

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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
Gianni Chessari, Ildiko M Buck, James E H Day, Philip J Day, Aman Iqbal, Alison J-A Woolford

J Med Chem· August 2015

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Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
Young Shin Cho, Hayley Angove, Christopher Brain, Christine Hiu-Tung Chen, Hong Cheng, Alison J-A Woolford

ACS Med Chem Lett· June 2012

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Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Andrew J Woodhead, Hayley Angove, Maria G Carr, Gianni Chessari, Miles Congreve, Alison J-A Woolford

J Med Chem· August 2010

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Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
Christopher W Murray, Maria G Carr, Owen Callaghan, Gianni Chessari, Miles Congreve, Alison J-A Woolford

J Med Chem· August 2010

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Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Paul G Wyatt, Andrew J Woodhead, Valerio Berdini, John A Boulstridge, Maria G Carr, Alison J-A Woolford

J Med Chem· August 2008

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Progressing single biomolecule force spectroscopy measurements for the screening of DNA binding agents.
Wenke Zhang, Romina Barbagallo, Claire Madden, Clive J Roberts, Alison Woolford

Nanotechnology· October 2005

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An inter-platform repeatability study investigating real-time amplification of plasmid DNA.
Carol E Donald, Fizza Qureshi, Malcolm J Burns, Marcia J Holden, Joseph R Blasic, Alison J Woolford

BMC Biotechnol· May 2005

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A comparison of enzymatic digestion for the quantitation of an oligonucleotide by liquid chromatography-isotope dilution mass spectrometry.
Carol E Donald, Peter Stokes, Gavin O'Connor, Alison J Woolford

J Chromatogr B Analyt Technol Biomed Life Sci· March 2005

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Synthesis of the thapsigargins.
Steven V Ley, Alessandra Antonello, Emily P Balskus, David T Booth, Søren B Christensen, Alison J A Woolford

Proc Natl Acad Sci U S A· August 2004

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Quantitation of oligonucleotides by phosphodiesterase digestion followed by isotope dilution mass spectrometry: proof of concept.
Gavin O'Connor, Carol Dawson, Alison Woolford, Kenneth S Webb, Tim Catterick

Anal Chem· August 2002

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Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome.
Julia J Scarisbrick, Alison J Woolford, Eduardo Calonje, Andrew Photiou, Sylvia Ferreira

J Invest Dermatol· March 2002

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