Publications by authors named "Amanda MacKenzie"

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Application of particle swarm optimization to understand the mechanism of action of allosteric inhibitors of the enzyme HSD17β13.
Amy Ford, Frauke Breitgoff, Miriam Pasquini, Amanda MacKenzie, Stuart McElroy

Patterns (N Y)· May 2023

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G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes.
Li-Chiung Lin, Tezz Quon, Susanna Engberg, Amanda E Mackenzie, Andrew B Tobin

ACS Pharmacol Transl Sci· December 2021

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High-frequency Ultrasound Assessment of Systemic Sclerosis Skin Involvement: Intraobserver Repeatability and Relationship With Clinician Assessment and Dermal Collagen Content.
Victoria A Flower, Shaney L Barratt, Darren J Hart, Amanda B Mackenzie, Jacqueline A Shipley

J Rheumatol· June 2021

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G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis.
Annemarie Boleij, Payam Fathi, William Dalton, Ben Park, Xinqun Wu, Amanda E Mackenzie

Commun Biol· May 2021

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Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Amanda E Mackenzie

Nature· December 2020

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Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Amanda E Mackenzie

Nature· November 2020

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: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications.
Maria Weber, Hai-Hao Han, Bo-Han Li, Maria L Odyniec, Charlotte E F Jarman, Amanda B Mackenzie

Chem Sci· August 2020

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Sensing Peroxynitrite in Different Organelles of Murine RAW264.7 Macrophages With Coumarin-Based Fluorescent Probes.
Maria Weber, Namiko Yamada, Xue Tian, Steven D Bull, Masafumi Minoshima, Amanda B Mackenzie

Front Chem· February 2020

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Receptor selectivity between the G proteins Gα and Gα is defined by a single leucine-to-isoleucine variation.
Amanda E Mackenzie, Tezz Quon, Li-Chiung Lin, Alexander S Hauser, Laura Jenkins

FASEB J· April 2019

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Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome.
Robin A Wickens, Luc Ver Donck, Amanda B MacKenzie, Sarah J Bailey

Behav Brain Res· October 2018

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Fluorescence-Based Tool To Detect Endogenous Peroxynitrite in M1-Polarized Murine J774.2 Macrophages.
Maria Weber, Amanda B Mackenzie, Steven D Bull, Tony D James

Anal Chem· September 2018

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Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35.
Nurul A S Binti Mohd Amir, Amanda E Mackenzie, Laura Jenkins, Karim Boustani, Marston C Hillier

J Immunol· July 2018

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De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.
Andrew E Fry, Katherine A Fawcett, Nathanel Zelnik, Hongjie Yuan, Belinda A N Thompson, Amanda B Mackenzie

Brain· March 2018

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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.
Jennifer E McCallum, Amanda E Mackenzie, Nina Divorty, Carolyn Clarke, Christian Delles

J Vasc Res· September 2017

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The emerging pharmacology and function of GPR35 in the nervous system.
Amanda E Mackenzie, Graeme Milligan

Neuropharmacology· February 2017

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Editorial: Roles of Ion Channels in Immune Cells.
Leanne Stokes, Amanda B MacKenzie, Ronald Sluyter

Front Immunol· February 2016

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Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.
Eugenia Sergeev, Anders Højgaard Hansen, Sunil K Pandey, Amanda E MacKenzie, Brian D Hudson

J Biol Chem· January 2016

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G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease.
Nina Divorty, Amanda E Mackenzie, Stuart A Nicklin, Graeme Milligan

Front Pharmacol· March 2015

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The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35.
Amanda E MacKenzie, Gianluigi Caltabiano, Toby C Kent, Laura Jenkins, Jennifer E McCallum

Mol Pharmacol· January 2014

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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Brian D Hudson, Bharat Shimpukade, Amanda E Mackenzie, Adrian J Butcher, John D Pediani

Mol Pharmacol· November 2013

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Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.
Brian D Hudson, Maria E Due-Hansen, Elisabeth Christiansen, Anna Mette Hansen, Amanda E Mackenzie

J Biol Chem· June 2013

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High-throughput identification and characterization of novel, species-selective GPR35 agonists.
Zaynab Neetoo-Isseljee, Amanda E MacKenzie, Craig Southern, Jeff Jerman, Edward G McIver

J Pharmacol Exp Ther· March 2013

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Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.
John G Foster, Edward Carter, Iain Kilty, Amanda B MacKenzie, Stephen G Ward

J Immunol· February 2013

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Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.
Laura Jenkins, Nicholas Harries, Jennifer E Lappin, Amanda E MacKenzie, Zaynab Neetoo-Isseljee

J Pharmacol Exp Ther· December 2012

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A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells.
Belinda A N Thompson, Michael P Storm, James Hewinson, Sarah Hogg, Melanie J Welham, Amanda B MacKenzie

Cell Signal· March 2012

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