Publications by authors named "Bryan Moyer"

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Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na1.8 with a Unique Mechanism of Action.
John M Gilchrist, Nien-Du Yang, Victoria Jiang, Bryan D Moyer

Mol Pharmacol· February 2024

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Discovery of pyridyl urea sulfonamide inhibitors of Na1.7.
John R Butler, Gwenaella Rescourio, Benjamin C Milgram, Robert S Foti, Thomas Kornecook, Bryan D Moyer

Bioorg Med Chem Lett· October 2022

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PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?
Jan Hoffmann, Silke Miller, Margarida Martins-Oliveira, Simon Akerman, Weera Supronsinchai, Bryan D Moyer

Pain· July 2020

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Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Na1.7 Inhibitors.
Hongkang Zhang, Bryan D Moyer, Violeta Yu, Joseph G McGivern, Michael Jarosh

SLAS Discov· June 2020

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Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.
Robert S Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Bryan Moyer

Drug Metab Dispos· October 2019

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Engineering Na1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics.
Justin K Murray, Bin Wu, Christopher M Tegley, Thomas E Nixey, James R Falsey, Bryan D Moyer

ACS Chem Biol· April 2019

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Discovery of Tarantula Venom-Derived Na1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.
Bin Wu, Justin K Murray, Kristin L Andrews, Kelvin Sham, Jason Long, Bryan D Moyer

J Med Chem· November 2018

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Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
Bryan D Moyer, Justin K Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau

PLoS One· August 2018

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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na1.7 inhibition.
Alessandro A Boezio, Kristin Andrews, Christiane Boezio, Margaret Chu-Moyer, Katrina W Copeland, Bryan D Moyer

Bioorg Med Chem Lett· June 2018

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Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats.
Sonya G Lehto, Andy D Weyer, Beth D Youngblood, Maosheng Zhang, Ruoyuan Yin, Bryan D Moyer

Mol Pain· October 2017

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Engineering Antibody Reactivity for Efficient Derivatization to Generate Na1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.
Kaustav Biswas, Thomas E Nixey, Justin K Murray, James R Falsey, Li Yin, Bryan D Moyer

ACS Chem Biol· September 2017

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The discovery of benzoxazine sulfonamide inhibitors of Na1.7: Tools that bridge efficacy and target engagement.
Daniel S La, Emily A Peterson, Christiane Bode, Alessandro A Boezio, Howard Bregman, Margaret Y Chu-Moyer, Bryan D Moyer

Bioorg Med Chem Lett· August 2017

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Discovery of a biarylamide series of potent, state-dependent Na1.7 inhibitors.
Laurie B Schenkel, Erin F DiMauro, Hanh N Nguyen, Nagasree Chakka, Bingfan Du, Bryan D Moyer

Bioorg Med Chem Lett· August 2017

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Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.
Matthew M Weiss, Thomas A Dineen, Isaac E Marx, Steven Altmann, Alessandro Boezio, Margaret Chu-Moyer, Bryan D Moyer

J Med Chem· July 2017

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Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
Russell F Graceffa, Alessandro A Boezio, Jessica Able, Steven Altmann, Loren M Berry, Margaret Chu-Moyer, Bryan D Moyer

J Med Chem· July 2017

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Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na1.7.
Thomas J Kornecook, Ruoyuan Yin, Stephen Altmann, Xuhai Be, Virginia Berry, Bryan D Moyer

J Pharmacol Exp Ther· July 2017

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Correction to "Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable Target Engagement".
Isaac E Marx, Thomas A Dineen, Jessica Able, Christiane Bode, Howard Bregman, Margaret Chu-Moyer, Bryan D Moyer

ACS Med Chem Lett· March 2017

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Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.
Isaac E Marx, Thomas A Dineen, Jessica Able, Christiane Bode, Howard Bregman, Margaret Chu-Moyer, Bryan D Moyer

ACS Med Chem Lett· December 2016

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Evaluation of recombinant monoclonal antibody SVmab1 binding to Na 1.7 target sequences and block of human Na 1.7 currents.
Dong Liu, Mandy Tseng, Linda F Epstein, Lydia Green, Brian Chan, Bryan D Moyer

F1000Res· November 2016

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Voltage-gated sodium channel function and expression in injured and uninjured rat dorsal root ganglia neurons.
Ruoyuan Yin, Dong Liu, Mark Chhoa, Chi-Ming Li, Yi Luo, Bryan D Moyer

Int J Neurosci· September 2016

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.
Erin F DiMauro, Stephen Altmann, Loren M Berry, Howard Bregman, Nagasree Chakka, Margaret Chu-Moyer, Bryan D Moyer

J Med Chem· September 2016

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Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.
Justin K Murray, Jason Long, Anruo Zou, Joseph Ligutti, Kristin L Andrews, Bryan D Moyer

J Med Chem· March 2016

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Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.
Justin K Murray, Kaustav Biswas, J Ryan Holder, Anruo Zou, Joseph Ligutti, Bryan D Moyer

Bioorg Med Chem Lett· November 2015

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Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.
Jacinthe Gingras, Sarah Smith, David J Matson, Danielle Johnson, Kim Nye, Bryan D Moyer

PLoS One· April 2015

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Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.
Justin K Murray, Joseph Ligutti, Dong Liu, Anruo Zou, Leszek Poppe, Bryan D Moyer

J Med Chem· March 2015

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