Publications by authors named "David Garrod"

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Catalytic Site Inhibitors of Group 1 Allergens Prevent Toll-like Receptor (TLR)4- and TLR1/2-Dependent Innate Responses in Keratinocytes and Airway Epithelial Cells Exposed to House Dust Mite Allergenic Extract.
Jihui Zhang, Jie Chen, Wen Hui Ng, Amir-Seena Saberi-Movahed, Zainab Rathore, David Garrod

ACS Pharmacol Transl Sci· October 2025

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Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases.
Jens Waschke, Masayuki Amagai, Christoph Becker, Mario Delmar, Firat Duru, David R Garrod

J Cell Sci· January 2025

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Proximity Mapping of Desmosomes Reveals a Striking Shift in Their Molecular Neighborhood Associated With Maturation.
Judith B Fülle, Rogerio Alves de Almeida, Craig Lawless, Liam Stockdale, Bian Yanes, David R Garrod

Mol Cell Proteomics· March 2024

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Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.
Jihui Zhang, Jie Chen, Jonathan P Richardson, Nicola-Jane Francis-Newton, Pei F Lai, David R Garrod

ACS Pharmacol Transl Sci· September 2022

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Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation.
Jonathan D Humphries, Junzhe Zha, Jessica Burns, Janet A Askari, Christopher R Below, David R Garrod

Matrix Biol· June 2022

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Desmosome dualism - most of the junction is stable, but a plakophilin moiety is persistently dynamic.
Judith B Fülle, Henri Huppert, David Liebl, Jaron Liu, Rogerio Alves de Almeida, David R Garrod

J Cell Sci· November 2021

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Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.
Jihui Zhang, Jie Chen, Jie Zuo, Gary K Newton, Mark R Stewart, David R Garrod

Int J Mol Sci· October 2018

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Pathways of airway oxidant formation by house dust mite allergens and viral RNA converge through myosin motors, pannexons and Toll-like receptor 4.
Jihui Zhang, Jie Chen, Shannon C Mangat, Chathuri Perera Baruhupolage, David R Garrod

Immun Inflamm Dis· June 2018

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Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis.
Hong Y Choi, Isabelle Ruel, Abba Malina, David R Garrod, Michael N Oda

Eur Heart J· April 2018

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Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin.
Jie Chen, Jihui Zhang, Theresa Tachie-Menson, Neha Shukla, David R Garrod

J Allergy Clin Immunol· June 2017

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Controlled laser texturing of titanium results in reliable osteointegration.
Melanie J Coathup, Gordon W Blunn, Nazanin Mirhosseini, Karen Erskine, Zhu Liu, David R Garrod

J Orthop Res· April 2017

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Innate generation of thrombin and intracellular oxidants in airway epithelium by allergen Der p 1.
Jihui Zhang, Jie Chen, Kimberley Allen-Philbey, Chathuri Perera Baruhupolage, Theresa Tachie-Menson, David R Garrod

J Allergy Clin Immunol· October 2016

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Down-regulation of desmosomes in cultured cells: the roles of PKC, microtubules and lysosomal/proteasomal degradation.
Selina McHarg, Gemma Hopkins, Lusiana Lim, David Garrod

PLoS One· June 2015

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Cadherin flexibility provides a key difference between desmosomes and adherens junctions.
Humera Tariq, Jordi Bella, Thomas A Jowitt, David F Holmes, Mansour Rouhi, David Garrod

Proc Natl Acad Sci U S A· April 2015

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The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Gary K Newton, Trevor R Perrior, Kerry Jenkins, Meriel R Major, Rebekah E Key, David R Garrod

J Med Chem· November 2014

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Hyper-adhesion: a unique property of desmosomes.
David Garrod, Lydia Tabernero

Cell Commun Adhes· October 2014

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A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes.
Svitlana Kurinna, Matthias Schäfer, Paola Ostano, Emmanuel Karouzakis, Giovanna Chiorino, David Garrod

Nat Commun· October 2014

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Desmosomal adhesion in vivo.
Mohamed Berika, David Garrod

Cell Commun Adhes· February 2014

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The assay that defines desmosome hyper-adhesion.
David R Garrod

J Invest Dermatol· February 2013

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Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.
Tomomi E Kimura, Anita J Merritt, Francesca R Lock, Judith J Eckert, Tom P Fleming, David R Garrod

Dev Biol· September 2012

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Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness.
Helen A Thomason, Nichola H Cooper, David M Ansell, Maybo Chiu, Anita J Merrit, David R Garrod

J Pathol· July 2012

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Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.
Siu Man Tsang, Louise Brown, Kuang Lin, Li Liu, Kim Piper, David R Garrod

J Pathol· May 2012

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An adult passive transfer mouse model to study desmoglein 3 signaling in pemphigus vulgaris.
Katja Schulze, Arnaud Galichet, Beyza S Sayar, Anthea Scothern, Denise Howald, David Garrod

J Invest Dermatol· February 2012

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Desmosomal cadherins in zebrafish epiboly and gastrulation.
Alexander Goonesinghe, Xing-Ming Luan, Adam Hurlstone, David Garrod

BMC Dev Biol· January 2012

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Future inhaled drugs by virtual innovation: allergen delivery inhibitors.
Clive Robinson, Jihui Zhang, David R Garrod, Gary K Newton, Kerry Jenkins

Future Med Chem· October 2011

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