Publications by authors named "Dennis Scott"

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Structural attributes influencing unbound tissue distribution.
Christine C Orozco, Karen Atkinson, Sangwoo Ryu, George Chang, Christopher Keefer, Dennis Scott

Eur J Med Chem· January 2020

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Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Kim F McClure, David W Piotrowski, Donna Petersen, Liuqing Wei, Jun Xiao, Dennis Scott

Angew Chem Int Ed Engl· December 2017

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Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies.
Jangir Selimkhanov, W Clayton Thompson, Terrell A Patterson, John R Hadcock, Dennis O Scott

PLoS One· July 2017

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Fluid resuscitation mediates the association between inhalational burn injury and acute kidney injury in the major burn population.
Avinash B Kumar, William Andrews, Yaping Shi, Matthew S Shotwell, Scott Dennis

J Crit Care· April 2017

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In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.
Patrick E Trapa, Kevin Beaumont, Karen Atkinson, Heather Eng, Amanda King-Ahmad, Dennis O Scott

J Pharm Sci· March 2017

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Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System.
Ayman F El-Kattan, Manthena V Varma, Stefan J Steyn, Dennis O Scott, Tristan S Maurer

Pharm Res· December 2016

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Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.
Huan-Chieh Chien, Arik A Zur, Tristan S Maurer, Sook Wah Yee, John Tolsma, Dennis O Scott

Drug Metab Dispos· March 2016

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Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration.
Patrick E Trapa, Elena Belova, Jenny L Liras, Dennis O Scott, Stefan J Steyn

J Pharm Sci· February 2016

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Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators.
Avijit Ghosh, Tristan S Maurer, John Litchfield, Manthema V Varma, Charles Rotter, Dennis O Scott

Drug Metab Dispos· October 2014

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Towards a unified model of passive drug permeation I: origins of the unstirred water layer with applications to ionic permeation.
Avijit Ghosh, Dennis O Scott, Tristan S Maurer

Eur J Pharm Sci· February 2014

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Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.
Li Di, Christopher Keefer, Dennis O Scott, Timothy J Strelevitz, George Chang, R Scott Obach

Eur J Med Chem· November 2012

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Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
Suvi T M Orr, Sharon L Ripp, T Eric Ballard, Jaclyn L Henderson, Dennis O Scott, R Scott Obach

J Med Chem· June 2012

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Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents.
Robert L Dow, Philip A Carpino, Denise Gautreau, John R Hadcock, Philip A Iredale, Dennis O Scott

ACS Med Chem Lett· May 2012

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Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists.
Kimberly O Cameron, Elena E Beretta, Yue Chen, Margaret Chu-Moyer, Dilinie Fernando, Dennis O Scott

Bioorg Med Chem Lett· April 2012

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Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor.
Michael Fichtner, Eunsun Lee, Elizabeth Tomlinson, Dennis Scott, Peter Cornelius

Bioorg Med Chem Lett· April 2012

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Excretion, metabolism, and pharmacokinetics of CP-945,598, a selective cannabinoid receptor antagonist, in rats, mice, and dogs.
Zhuang Miao, Dennis O Scott, David A Griffith, Robert Day, Chandra Prakash

Drug Metab Dispos· December 2011

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Systematic and pairwise analysis of the effects of aromatic halogenation and trifluoromethyl substitution on human liver microsomal clearance.
Hao Sun, Christopher E Keefer, Dennis O Scott

Drug Metab Lett· December 2011

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Impact of genetic polymorphisms of cytochrome P450 2 C (CYP2C) enzymes on the drug metabolism and design of antidiabetics.
Hao Sun, Dennis O Scott

Chem Biol Interact· November 2011

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Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design.
Hao Sun, Dennis O Scott

ACS Med Chem Lett· August 2011

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Species independence in brain tissue binding using brain homogenates.
Li Di, John P Umland, George Chang, Youping Huang, Zhen Lin, Dennis O Scott

Drug Metab Dispos· July 2011

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Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity.
Richard L Elliott, Kimberly O Cameron, Janice E Chin, Jeremy A Bartlett, Elena E Beretta, Dennis O Scott

Bioorg Med Chem Lett· November 2010

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Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.
John R Hadcock, Philip A Carpino, Philip A Iredale, Robert L Dow, Denise Gautreau, Dennis O Scott

BMC Pharmacol· August 2010

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Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discovery.
George Chang, Stefanus J Steyn, John P Umland, Dennis O Scott

ACS Med Chem Lett· May 2010

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In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB(1) receptor antagonist for the management of obesity.
John R Hadcock, David A Griffith, Phillip A Iredale, Phillip A Carpino, Robert L Dow, Dennis O Scott

Biochem Biophys Res Commun· April 2010

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Structure-based drug metabolism predictions for drug design.
Hao Sun, Dennis O Scott

Chem Biol Drug Des· January 2010

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