Publications by authors named "Eric A Murphy"

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Targeting BRAF Class II and III Mutations in NSCLC with the pan-RAF inhibitor Exarafenib Reveals ARAF-KSR1-Mediated Resistance and Rational Combination Strategies.
Tadashi Manabe, Hannah C Bergo, Qingtian Li, Tim Sen Wang, Paul Severson, Eric A Murphy

Res Sq· October 2025

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
Young K Chen, Toufike Kanouni, Lee D Arnold, Jason M Cox, Elisabeth Gardiner, Eric A Murphy

J Med Chem· February 2024

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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
John S Tyhonas, Lee D Arnold, Jason M Cox, Aleksandra Franovic, Elisabeth Gardiner, Eric A Murphy

J Med Chem· February 2024

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EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1.
Steven K M Lau, David J Shields, Eric A Murphy, Jay S Desgrosellier, Sudarshan Anand

PLoS One· September 2012

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Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.
Lea Scheppke, Eric A Murphy, Alessandro Zarpellon, Jennifer J Hofmann, Alona Merkulova

Blood· March 2012

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A MEK-independent role for CRAF in mitosis and tumor progression.
Ainhoa Mielgo, Laetitia Seguin, Miller Huang, Maria Fernanda Camargo, Sudarshan Anand, Eric A Murphy

Nat Med· November 2011

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Targeted nanogels: a versatile platform for drug delivery to tumors.
Eric A Murphy, Bharat K Majeti, Rajesh Mukthavaram, Lisette M Acevedo, Leo A Barnes

Mol Cancer Ther· June 2011

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MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis.
Sudarshan Anand, Bharat K Majeti, Lisette M Acevedo, Eric A Murphy, Rajesh Mukthavaram

Nat Med· August 2010

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Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF.
Eric A Murphy, David J Shields, Konstantin Stoletov, Elena Dneprovskaia, Michele McElroy

Proc Natl Acad Sci U S A· March 2010

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RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.
David J Shields, Sherry Niessen, Eric A Murphy, Ainhoa Mielgo, Jay S Desgrosellier

Proc Natl Acad Sci U S A· February 2010

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Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation.
Wonshill Koh, Kamakshi Sachidanandam, Amber N Stratman, Anastasia Sacharidou, Anne M Mayo, Eric A Murphy

J Cell Sci· June 2009

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Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis.
Eric A Murphy, Bharat K Majeti, Leo A Barnes, Milan Makale, Sara M Weis

Proc Natl Acad Sci U S A· July 2008

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