Publications by authors named "Heather Hinton"

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Dose escalation study of the HLA-A2-WT1 CD3 bispecific antibody RO7283420 in relapsed/refractory acute myeloid leukemia.
Martin Hutchings, Koorosh Korfi, Pau Montesinos, Armando Santoro, Hsin-An Hou, Heather Hinton

Blood Neoplasia· August 2025

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Ipatasertib plus Paclitaxel for Patients with PIK3CA/AKT1/PTEN-Altered Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer in the IPATunity130 Phase III Trial.
Rebecca A Dent, Sung-Bae Kim, Mafalda Oliveira, Carlos Barrios, Joyce O'Shaughnessy, Heather Hinton

Clin Cancer Res· October 2024

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Mitigating ipatasertib-induced glucose increase through dose and meal timing modifications.
Dhruvitkumar S Sutaria, Priya Agarwal, Kuan-Chieh Huang, Dale R Miles, Jacob Rotmensch, Heather Hinton

Clin Transl Sci· December 2022

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Characterization of exposure-response relationships of ipatasertib in patients with metastatic castration-resistant prostate cancer in the IPATential150 study.
Naoki Kotani, Justin J Wilkins, Janet R Wade, Steve Dang, Dhruvitkumar S Sutaria, Heather Hinton

Cancer Chemother Pharmacol· December 2022

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Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab.
Nicolas Frances, Marina Bacac, Katharine Bray-French, François Christen, Heather Hinton

J Pharm Sci· April 2022

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Ipatasertib plus paclitaxel for PIK3CA/AKT1/PTEN-altered hormone receptor-positive HER2-negative advanced breast cancer: primary results from cohort B of the IPATunity130 randomized phase 3 trial.
Nicholas Turner, Rebecca A Dent, Joyce O'Shaughnessy, Sung-Bae Kim, Steven J Isakoff, Heather Hinton

Breast Cancer Res Treat· February 2022

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Development of the first reference antibody panel for qualification and validation of cytokine release assay platforms - Report of an international collaborative study.
Sandrine Vessillier, Madeline Fort, Lynn O'Donnell, Heather Hinton, Kimberly Nadwodny

Cytokine X· December 2020

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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease.
Laurence B Peterson, Charles J M Bell, Sarah K Howlett, Marcin L Pekalski, Kevin Brady, Heather Hinton

J Autoimmun· December 2018

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CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies.
Marina Bacac, Sara Colombetti, Sylvia Herter, Johannes Sam, Mario Perro, Heather Hinton

Clin Cancer Res· October 2018

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Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?
Yoshika Iwata, Asako Harada, Toshiko Hara, Chiyomi Kubo, Tomoaki Inoue, Heather Hinton

J Toxicol Sci· April 2017

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Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.
Christian Klein, Inja Waldhauer, Valeria G Nicolini, Anne Freimoser-Grundschober, Tapan Nayak, Heather Hinton

Oncoimmunology· January 2017

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Application of a MABEL Approach for a T-Cell-Bispecific Monoclonal Antibody: CEA TCB.
Sherri Dudal, Heather Hinton, Anna M Giusti, Marina Bacac, Magali Muller

J Immunother· September 2016

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A real-time impedance-based screening assay for drug-induced vascular leakage.
Stefan Kustermann, Tobias Manigold, Corinne Ploix, Marion Skubatz, Tobias Heckel, Heather Hinton

Toxicol Sci· April 2014

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A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies.
Lucy Bailey, Laura Moreno, Tobias Manigold, Sebastian Krasniqi, Harald Kropshofer, Heather Hinton

J Pharmacol Toxicol Methods· March 2014

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Current challenges and opportunities in nonclinical safety testing of biologics.
Sven Kronenberg, Andreas Baumann, Lolke de Haan, Heather J Hinton, Jonathan Moggs

Drug Discov Today· December 2013

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Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses.
Juliana Bessa, Franziska Zabel, Alexander Link, Andrea Jegerlehner, Heather J Hinton

Proc Natl Acad Sci U S A· December 2012

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Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.
Juliana Bessa, Andrea Jegerlehner, Heather J Hinton, Paul Pumpens, Philippe Saudan

J Immunol· September 2009

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Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.
Caroline E von Allmen, Nicole Schmitz, Monika Bauer, Heather J Hinton, Michael O Kurrer

Proc Natl Acad Sci U S A· July 2009

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Follicular and marginal zone B cells fail to cross-present MHC class I-restricted epitopes derived from viral particles.
Susanne A Keller, Caroline E von Allmen, Heather J Hinton, Monika Bauer, Simone Muntwiler

J Immunol· May 2009

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Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design.
Juliana Bessa, Nicole Schmitz, Heather J Hinton, Katrin Schwarz, Andrea Jegerlehner

Eur J Immunol· January 2008

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Notch-induced T cell development requires phosphoinositide-dependent kinase 1.
April P Kelly, David K Finlay, Heather J Hinton, Rosie G Clarke, Emma Fiorini

EMBO J· July 2007

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TLR9 signaling in B cells determines class switch recombination to IgG2a.
Andrea Jegerlehner, Patrik Maurer, Juliana Bessa, Heather J Hinton, Manfred Kopf

J Immunol· February 2007

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Regulation of memory antibody levels: the role of persisting antigen versus plasma cell life span.
Dominique Gatto, Stephen W Martin, Juliana Bessa, Erica Pellicioli, Philippe Saudan, Heather J Hinton

J Immunol· January 2007

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VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.
Lorenz Vogt, Nicole Schmitz, Michael O Kurrer, Monika Bauer, Heather I Hinton

J Clin Invest· October 2006

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Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development.
Heather J Hinton, Rosemary G Clarke, Doreen A Cantrell

FEBS Lett· October 2006

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