Publications by authors named "Ho-Man Chan"

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The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer.
Srushti Kittane, Erik Ladewig, Taibo Li, Jillian R Love, Ryan Blawski, Ho Man Chan

Cancer Res· December 2025

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Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment.
Youyou Zhang, Mu Xu, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Ho Man Chan

bioRxiv· August 2025

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Pharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcoma.
Yao Yu, Xufen Yu, Bo Pan, Ho Man Chan, H Ümit Kaniskan

Sci Adv· April 2025

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Cancer epigenetic therapy: recent advances, challenges, and emerging opportunities.
Rajita Vatapalli, Alex P Rossi, Ho Man Chan, Jingwen Zhang

Epigenomics· January 2025

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Discovery of FHD-286, a First-in-Class, Orally Bioavailable, Allosteric Dual Inhibitor of the Brahma Homologue (BRM) and Brahma-Related Gene 1 (BRG1) ATPase Activity for the Treatment of SWItch/Sucrose Non-Fermentable (SWI/SNF) Dependent Cancers.
Rishi G Vaswani, David S Huang, Neville Anthony, Lan Xu, Richard Centore, Ho Man Chan

J Med Chem· January 2025

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Discovery and Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
James M Smith, Bernard Barlaam, David Beattie, Lauren Bradshaw, Ho Man Chan, Mercedes Vazquez-Chantada

J Med Chem· August 2024

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.
Ryan Blawski, Bujamin H Vokshi, Xinyu Guo, Srushti Kittane, Mirna Sallaku, Ho Man Chan

Cell Rep· May 2024

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BET inhibition targets ABC-DLBCL constitutive B-cell receptor signaling through PAX5.
Derek B Oien, Samanta Sharma, Maureen M Hattersley, Michelle DuPont, Steven W Criscione, Ho Man Chan

Blood Adv· September 2023

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Systematic illumination of druggable genes in cancer genomes.
Junjie Jiang, Jiao Yuan, Zhongyi Hu, Youyou Zhang, Tianli Zhang, Ho Man Chan

Cell Rep· February 2022

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Systematic Pan-Cancer Characterization of Nuclear Receptors Identifies Potential Cancer Biomarkers and Therapeutic Targets.
Junjie Jiang, Jiao Yuan, Zhongyi Hu, Mu Xu, Youyou Zhang, Ho Man Chan

Cancer Res· January 2022

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The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets.
Zhongyi Hu, Jiao Yuan, Meixiao Long, Junjie Jiang, Youyou Zhang, Ho Man Chan

Nat Cancer· December 2021

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Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies.
Richard C Centore, Gabriel J Sandoval, Luis Miguel Mendes Soares, Cigall Kadoch, Ho Man Chan

Trends Genet· December 2020

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A family of diastereomeric dodecanuclear coordination cages based on inversion of chirality of individual triangular cyclic helicate faces.
Stephen P Argent, Fiona C Jackson, Ho Man Chan, Sam Meyrick, Christopher G P Taylor

Chem Sci· September 2020

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A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation.
Brittany C Michel, Andrew R D'Avino, Seth H Cassel, Nazar Mashtalir, Zachary M McKenzie, Ho Man Chan

Nat Cell Biol· December 2018

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TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.
Robert M Witwicki, Muhammad B Ekram, Xintao Qiu, Michalina Janiszewska, Shaokun Shu, Ho Man Chan

Cell Rep· October 2018

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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Wei Qi, Kehao Zhao, Justin Gu, Ying Huang, Youzhen Wang, HoMan Chan

Nat Chem Biol· April 2017

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Ying-Nan P Chen, Matthew J LaMarche, Ho Man Chan, Peter Fekkes, Jorge Garcia-Fortanet

Nature· July 2016

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Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Jonathan R LaRochelle, Michelle Fodor, Xiang Xu, Izabela Durzynska, Lixin Fan, Ho Man Chan

Biochemistry· April 2016

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A chemical genetics approach for the functional assessment of novel cancer genes.
Qianhe Zhou, Adnan Derti, David Ruddy, Daniel Rakiec, Iris Kao, HoMan Chan

Cancer Res· May 2015

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Direct quantification of circulating miRNAs in different stages of nasopharyngeal cancerous serum samples in single molecule level with total internal reflection fluorescence microscopy.
See-Lok Ho, Ho-Man Chan, Amber Wai-Yan Ha, Ricky Ngok-Shun Wong, Hung-Wing Li

Anal Chem· October 2014

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Self-assembling protein platform for direct quantification of circulating microRNAs in serum with total internal reflection fluorescence microscopy.
See-Lok Ho, Ho-Man Chan, Ricky Ngok-Shun Wong, Hung-Wing Li

Anal Chim Acta· May 2014

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Monitoring of DNA-protein interaction with single gold nanoparticles by localized scattering plasmon resonance spectroscopy.
Kin-Man Lo, Chung-Yin Lai, Ho-Man Chan, Dik-Lung Ma, Hung-Wing Li

Methods· December 2013

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A liquid chromatography/mass spectrometry-based generic detection method for biochemical assay and hit discovery of histone methyltransferases.
Shu Li, X Justin Gu, Qin Hao, Hong Fan, Ling Li, Ho Man Chan

Anal Biochem· December 2013

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.
Jacob D Jaffe, Yan Wang, Ho Man Chan, Jinghui Zhang, Robert Huether

Nat Genet· November 2013

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Folate-conjugated FeO@SiO@gold nanorods@mesoporous SiO hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy.
Da-Wei Wang, Xiao-Ming Zhu, Siu-Fung Lee, Ho-Man Chan, Hung-Wing Li

J Mater Chem B· June 2013

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