Publications by authors named "John McCarter"

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Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter

Nat Cancer· January 2024

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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Nuria A Tamayo, Matthew P Bourbeau, Jennifer R Allen, Kate S Ashton, Jian Jeffrey Chen, John D McCarter

J Med Chem· March 2022

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Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS).
Aniruddha Sahasrabuddhe, Dylan Oakley, Kui Chen, John D McCarter

SLAS Discov· February 2021

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Systematic Study of the Glutathione Reactivity of -Phenylacrylamides: 2. Effects of Acrylamide Substitution.
Adam Birkholz, David J Kopecky, Laurie P Volak, Michael D Bartberger, Yuping Chen, John D McCarter

J Med Chem· October 2020

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Discovery of a Covalent Inhibitor of KRAS (AMG 510) for the Treatment of Solid Tumors.
Brian A Lanman, Jennifer R Allen, John G Allen, Albert K Amegadzie, Kate S Ashton, John D McCarter

J Med Chem· January 2020

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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Jude Canon, Karen Rex, Anne Y Saiki, Christopher Mohr, Keegan Cooke, John D McCarter

Nature· November 2019

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Discovery of -(1-Acryloylazetidin-3-yl)-2-(1-indol-1-yl)acetamides as Covalent Inhibitors of KRAS.
Youngsook Shin, Joon Won Jeong, Ryan P Wurz, Pragathi Achanta, Tara Arvedson, John McCarter

ACS Med Chem Lett· September 2019

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A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation.
Ryan P Wurz, Ken Dellamaggiore, Hannah Dou, Noelle Javier, Mei-Chu Lo, John D McCarter

J Med Chem· January 2018

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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
John G Allen, Mirna Mujacic, Michael J Frohn, Alex J Pickrell, Paul Kodama, John D McCarter

ACS Chem Biol· October 2016

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Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430).
Felix Gonzalez-Lopez de Turiso, Xiaolin Hao, Youngsook Shin, Minna Bui, Iain D G Campuzano, John McCarter

J Med Chem· August 2016

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High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow.
Iain D G Campuzano, Tisha San Miguel, Todd Rowe, Daniel Onea, Victor J Cee, John D McCarter

J Biomol Screen· February 2016

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Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
Youngsook Shin, Julia Suchomel, Mario Cardozo, Jason Duquette, Xiao He, John McCarter

J Med Chem· January 2016

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Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution.
Victor J Cee, Laurie P Volak, Yuping Chen, Michael D Bartberger, Chris Tegley, John McCarter

J Med Chem· December 2015

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Development of a nucleotide sugar purification method using a mixed mode column & mass spectrometry detection.
Heather Eastwood, Fang Xia, Mei-Chu Lo, Jing Zhou, John B Jordan, John McCarter

J Pharm Biomed Anal· November 2015

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The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.
Markian M Stec, Kristin L Andrews, Yunxin Bo, Sean Caenepeel, Hongyu Liao, John McCarter

Bioorg Med Chem Lett· October 2015

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Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Minna Bui, Xiaolin Hao, Youngsook Shin, Mario Cardozo, Xiao He, John McCarter

Bioorg Med Chem Lett· March 2015

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Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures.
Zhimei Du, David Treiber, John D McCarter, Dina Fomina-Yadlin, Ramsey A Saleem

Biotechnol Bioeng· January 2015

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Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
Timothy D Cushing, Xiaolin Hao, Youngsook Shin, Kristin Andrews, Matthew Brown, John D McCarter

J Med Chem· January 2015

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Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Brian A Lanman, Anthony B Reed, Victor J Cee, Fang-Tsao Hong, Liping H Pettus, John D McCarter

Bioorg Med Chem Lett· December 2014

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Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, Chester Yuan, Albert Amegadzie, John D McCarter

Bioorg Med Chem Lett· December 2013

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Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay.
Ada Chen, Xiaoning Zhao, Laina Mercer, Cheng Su, Leeanne Zalameda, John D McCarter

Comb Chem High Throughput Screen· September 2013

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IgG1 thioether bond formation in vivo.
Qingchun Zhang, Matthew R Schenauer, John D McCarter, Gregory C Flynn

J Biol Chem· June 2013

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Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Ryan P Wurz, Longbin Liu, Kevin Yang, Nobuko Nishimura, Yunxin Bo, John D McCarter

Bioorg Med Chem Lett· September 2012

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Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
Mark H Norman, Kristin L Andrews, Yunxin Y Bo, Shon K Booker, Sean Caenepeel, John D McCarter

J Med Chem· September 2012

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Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
Adrian L Smith, Noel D D'Angelo, Yunxin Y Bo, Shon K Booker, Victor J Cee, John D McCarter

J Med Chem· June 2012

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