Publications by authors named "John Menke"

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An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex.
Franz-Ferdinand Roch, Georg Hinterkörner, John Menke, Guo-Qing Tang, Stephen Cusack

Assay Drug Dev Technol· October 2015

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Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines.
Javier de Vicente, Remy Lemoine, Mark Bartlett, Johannes C Hermann, Mohammad Hekmat-Nejad, John Menke

Bioorg Med Chem Lett· November 2014

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Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.
Matthew C Lucas, Niala Bhagirath, Eric Chiao, David M Goldstein, Johannes C Hermann, John Menke

J Med Chem· March 2014

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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.
Cheng Liao, Jonathan Hsu, Yong Kim, Dong-Qing Hu, Daigen Xu, John Menke

Arthritis Res Ther· October 2013

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Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome.
Stephen M Lynch, Javier DeVicente, Johannes C Hermann, Saul Jaime-Figueroa, Sue Jin, John Menke

Bioorg Med Chem Lett· May 2013

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Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.
Saul Jaime-Figueroa, Javier De Vicente, Johannes Hermann, Alam Jahangir, Sue Jin, John Menke

Bioorg Med Chem Lett· May 2013

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Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
Fernando Padilla, Niala Bhagirath, Shaoqing Chen, Eric Chiao, David M Goldstein, John Menke

J Med Chem· February 2013

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Metal impurities cause false positives in high-throughput screening campaigns.
Johannes C Hermann, Yingsi Chen, Charles Wartchow, John Menke, Lin Gao

ACS Med Chem Lett· February 2013

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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.
Alison M Strack, Ester Carballo-Jane, Sheng-Ping Wang, Jiyan Xue, Xiaoli Ping, John Menke

J Lipid Res· January 2013

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3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
Michael Soth, Johannes C Hermann, Calvin Yee, Muzaffar Alam, Jim W Barnett, John Menke

J Med Chem· January 2013

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Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
Lin Chu, Helen M Armstrong, Linda L Chang, Amy F Cheng, Lawrence Colwell, John Menke

Bioorg Med Chem Lett· June 2012

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A gene expression signature that classifies human atherosclerotic plaque by relative inflammation status.
Oscar Puig, Jeffrey Yuan, Sergey Stepaniants, Renata Zieba, Emanuel Zycband, John Menke

Circ Cardiovasc Genet· December 2011

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The nuclear membrane organization of leukotriene synthesis.
Asim K Mandal, Phillip B Jones, Angela M Bair, Peter Christmas, Douglas Miller, John Menke

Proc Natl Acad Sci U S A· December 2008

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Development of a high-capacity homogeneous fluorescent assay for the measurement of leukotriene B4.
Douglas K Miller, John D Menke, Nancy S Hayes, Adam Uzieblo, Daniel Tew

Anal Biochem· February 2006

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Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.
Erik G Lund, Laurence B Peterson, Alan D Adams, My-Hanh N Lam, Charlotte A Burton, John G Menke

Biochem Pharmacol· February 2006

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Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.
Weiguo Liu, Steve Chen, James Dropinski, Lawrence Colwell, Michael Robins, John G Menke

Bioorg Med Chem Lett· October 2005

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Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents.
Kithsiri B Herath, Hiranthi Jayasuriya, Ziqiang Guan, Marvin Schulman, Carolyn Ruby, John G Menke

J Nat Prod· September 2005

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Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors.
John G Ondeyka, Hiranthi Jayasuriya, Kithsiri B Herath, Ziqiang Guan, Marvin Schulman, John G Menke

J Antibiot (Tokyo)· September 2005

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Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.
Hiranthi Jayasuriya, Kithsiri B Herath, John G Ondeyka, Ziqiang Guan, Robert P Borris, John G Menke

J Nat Prod· August 2005

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Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.
Sheo B Singh, John G Ondeyka, Weiguo Liu, Steve Chen, Tom S Chen, John G Menke

Bioorg Med Chem Lett· June 2005

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Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.
Kithsiri Herath, Hiranthi Jayasuriya, John G Ondeyka, Ziqiang Guan, Robert P Borris, John G Menke

J Nat Prod· April 2005

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Miniaturization of cell-based beta-lactamase-dependent FRET assays to ultra-high throughput formats to identify agonists of human liver X receptors.
Jayne Chin, Alan D Adams, Aileen Bouffard, Ahren Green, Raul G Lacson, John G Menke

Assay Drug Dev Technol· December 2003

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Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis.
Erik G Lund, John G Menke, Carl P Sparrow

Arterioscler Thromb Vasc Biol· July 2003

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A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a).
John G Menke, Karen L Macnaul, Nancy S Hayes, Joanne Baffic, Yu-Sheng Chao

Endocrinology· July 2002

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Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway.
Rebecca Kaplan, Xiaodong Gan, John G Menke, Samuel D Wright, Tian-Quan Cai

J Lipid Res· June 2002

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