Publications by authors named "Lawrence Colwell"

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Efficacy of Relebactam (MK-7655) in Combination with Imipenem-Cilastatin in Murine Infection Models.
Mary Ann Powles, Andrew Galgoci, Andrew Misura, Lawrence Colwell, Karen H Dingley

Antimicrob Agents Chemother· August 2018

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Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
Lin Chu, Helen M Armstrong, Linda L Chang, Amy F Cheng, Lawrence Colwell

Bioorg Med Chem Lett· June 2012

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Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.
Qiang Tan, Aimie M Ogawa, Susan L Raghoobar, Douglas Wisniewski, Lawrence Colwell

Bioorg Med Chem Lett· July 2011

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Control of rat tail skin temperature regulation by estrogen receptor-beta selective ligand.
Evan E Opas, Angela Scafonas, Pascale V Nantermet, Robert R Wilkening, Elizabeth T Birzin, Lawrence F Colwell

Maturitas· September 2009

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Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides.
Libo Xu, Amy K Farthing, James F Dropinski, Peter T Meinke, Christine McCallum, Lawrence Colwell

Bioorg Med Chem Lett· July 2009

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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume.
John J Acton, Taro E Akiyama, Ching H Chang, Lawrence Colwell, Sheryl Debenham

J Med Chem· July 2009

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Highly functionalized 7-azaindoles as selective PPAR gamma modulators.
Sheryl D Debenham, Audrey Chan, Fiona Waiyu Lau, Weiguo Liu, Harold B Wood, Lawrence Colwell

Bioorg Med Chem Lett· September 2008

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Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists.
Dann L Parker, Dongfang Meng, Ronald W Ratcliffe, Robert R Wilkening, Donald M Sperbeck, Lawrence F Colwell

Bioorg Med Chem Lett· September 2006

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Jun Wang, Stephen M Soisson, Katherine Young, Wesley Shoop, Srinivas Kodali, Lawrence Colwell

Nature· May 2006

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Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.
Weiguo Liu, Steve Chen, James Dropinski, Lawrence Colwell, Michael Robins

Bioorg Med Chem Lett· October 2005

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Selective PPARgamma modulators with improved pharmacological profiles.
Kun Liu, Regina M Black, John J Acton, Ralph Mosley, Sheryl Debenham, Lawrence Colwell

Bioorg Med Chem Lett· May 2005

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Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Qiang Tan, Timothy A Blizzard, Jerry D Morgan, Elizabeth T Birzin, Wanda Chan, Lawrence Colwell

Bioorg Med Chem Lett· March 2005

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Benzoyl 2-methyl indoles as selective PPARgamma modulators.
John J Acton, Regina M Black, A Brian Jones, David E Moller, Lawrence Colwell

Bioorg Med Chem Lett· January 2005

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Potent and selective proline derived dipeptidyl peptidase IV inhibitors.
Scott D Edmondson, Anthony Mastracchio, Maria Beconi, Lawrence F Colwell, Bahanu Habulihaz

Bioorg Med Chem Lett· October 2004

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A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.
David B Olsen, Anne B Eldrup, Linda Bartholomew, Balkrishen Bhat, Michele R Bosserman, Lawrence F Colwell

Antimicrob Agents Chemother· October 2004

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Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
Anne B Eldrup, Marija Prhavc, Jennifer Brooks, Balkrishen Bhat, Thazha P Prakash, Lawrence F Colwell

J Med Chem· October 2004

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Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors.
Jinyou Xu, Hyun O Ok, Edward J Gonzalez, Lawrence F Colwell, Bahanu Habulihaz

Bioorg Med Chem Lett· September 2004

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Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.
Linda L Brockunier, Jiafang He, Lawrence F Colwell, Bahanu Habulihaz, Huaibing He

Bioorg Med Chem Lett· September 2004

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Comparison of the effects of perfusion in determining brain penetration (brain-to-plasma ratios) of small molecules in rats.
Judith E Fenyk-Melody, Xiaolan Shen, Qianping Peng, William Pikounis, Lawrence Colwell

Comp Med· August 2004

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Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs.
Seongkon Kim, Jane Wu, Helen Y Chen, Elizabeth T Birzin, Wanda Chan, Lawrence Colwell

Bioorg Med Chem Lett· June 2004

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.
Giovanni Migliaccio, Joanne E Tomassini, Steven S Carroll, Licia Tomei, Sergio Altamura, Lawrence F Colwell

J Biol Chem· December 2003

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Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method.
Lawrence F Colwell, Constantin S Tamvakopoulos, Pei Ran Wang, James V Pivnichny, Thomas L Shih

J Chromatogr B Analyt Technol Biomed Life Sci· May 2002

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