Publications by authors named "Jonathan Houze"

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Cardiovascular response to small-molecule APJ activation.
Brandon Ason, Yinhong Chen, Qi Guo, Kimberly M Hoagland, Ray W Chui, Jonathan Houze

JCI Insight· April 2020

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Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
Gwenaella Rescourio, Ana Z Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Jonathan Houze

J Med Chem· November 2019

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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Sean Caenepeel, Sean P Brown, Brian Belmontes, Gordon Moody, Kathleen S Keegan, Jonathan Houze

Cancer Discov· December 2018

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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.
Sean P Brown, Paul Dransfield, Marc Vimolratana, Liusheng Zhu, Jian Luo, Jonathan B Houze

ACS Med Chem Lett· July 2018

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5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.
Todd J Kohn, Xiaohui Du, SuJen Lai, YuMei Xiong, Renee Komorowski, Jonathan Houze

ACS Med Chem Lett· July 2016

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.
Paul J Dransfield, Vatee Pattaropong, Sujen Lai, Zice Fu, Todd J Kohn, Jonathan Houze

ACS Med Chem Lett· July 2016

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Discovery of the imidazole-derived GPR40 agonist AM-3189.
Zhihua Ma, Daniel C-H Lin, Rajiv Sharma, Jinqian Liu, Liusheng Zhu, Jonathan B Houze

Bioorg Med Chem Lett· January 2016

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Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
Yosup Rew, Daqing Sun, Xuelei Yan, Hilary P Beck, Jude Canon, Jonathan Houze

J Med Chem· December 2014

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Convenient route to secondary sulfinates: application to the stereospecific synthesis of α-C-chiral sulfonamides.
Michael G Johnson, Michael W Gribble, Jonathan B Houze, Nick A Paras

Org Lett· December 2014

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.
Xiaohui Du, Ronald J Hinklin, Yumei Xiong, Paul Dransfield, Jaehyeon Park, Jonathan B Houze

ACS Med Chem Lett· December 2014

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Discovery of 2-pyridylureas as glucokinase activators.
Ronald J Hinklin, Thomas D Aicher, Deborah A Anderson, Brian R Baer, Steven A Boyd, Jonathan B Houze

J Med Chem· October 2014

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Optimization of GPR40 Agonists for Type 2 Diabetes.
Jiwen Jim Liu, Yingcai Wang, Zhihua Ma, Mike Schmitt, Liusheng Zhu, Jonathan B Houze

ACS Med Chem Lett· May 2014

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Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.
Ana Z Gonzalez, Zhihong Li, Hilary P Beck, Jude Canon, Ada Chen, Jonathan Houze

J Med Chem· April 2014

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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists.
Xiaohui Du, Paul J Dransfield, Daniel C-H Lin, Simon Wong, Yingcai Wang, Jonathan B Houze

ACS Med Chem Lett· April 2014

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Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
Ana Z Gonzalez, John Eksterowicz, Michael D Bartberger, Hilary P Beck, Jude Canon, Jonathan B Houze

J Med Chem· March 2014

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Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
Daqing Sun, Zhihong Li, Yosup Rew, Michael Gribble, Michael D Bartberger, Jonathan B Houze

J Med Chem· February 2014

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Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.
Ming Yu, Mike Lizarzaburu, Alykhan Motani, Zice Fu, Xiaohui Du, Jonathan B Houze

ACS Med Chem Lett· September 2013

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A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.
Jian Luo, Gayathri Swaminath, Sean P Brown, Jane Zhang, Qi Guo, Jonathan B Houze

PLoS One· June 2013

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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles.
Yingcai Wang, Jiwen Jim Liu, Paul J Dransfield, Liusheng Zhu, Zhongyu Wang, Jonathan B Houze

ACS Med Chem Lett· June 2013

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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.
Yumei Xiong, Gayathri Swaminath, Qiong Cao, Li Yang, Qi Guo, Jonathan B Houze

Mol Cell Endocrinol· April 2013

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Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
Joshua P Taygerly, Lawrence R McGee, Steven M Rubenstein, Jonathan B Houze, Timothy D Cushing

Bioorg Med Chem· February 2013

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Evaluating insulin secretagogues in a humanized mouse model with functional human islets.
Jian Luo, Kathy Nguyen, Michael Chen, Than Tran, Jianqiang Hao, Jonathan Houze

Metabolism· January 2013

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Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.
Xiaohui Du, Yong-Jae Kim, Sujen Lai, Xi Chen, Mike Lizarzaburu, Jonathan Houze

Bioorg Med Chem Lett· October 2012

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Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus.
Mike Lizarzaburu, Simon Turcotte, Xiaohui Du, Jason Duquette, Angela Fu, Jonathan Houze

Bioorg Med Chem Lett· September 2012

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Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.
Sean P Brown, Paul J Dransfield, Marc Vimolratana, XianYun Jiao, Liusheng Zhu, Jonathan B Houze

ACS Med Chem Lett· September 2012

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